BÁRTA, Tomáš, Dáša DOLEŽALOVÁ, Zuzana HOLUBCOVÁ and Aleš HAMPL. Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture. Experimental Biology and Medicine. LONDON: Mayvood, 2013, vol. 238, No 3, p. 271-275. ISSN 1535-3702. doi:10.1177/1535370213480711.
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Basic information
Original name Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture
Authors BÁRTA, Tomáš (203 Czech Republic, belonging to the institution), Dáša DOLEŽALOVÁ (703 Slovakia, belonging to the institution), Zuzana HOLUBCOVÁ (203 Czech Republic, belonging to the institution) and Aleš HAMPL (203 Czech Republic, guarantor, belonging to the institution).
Edition Experimental Biology and Medicine, LONDON, Mayvood, 2013, 1535-3702.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.226
RIV identification code RIV/00216224:14110/13:00066243
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1177/1535370213480711
UT WoS 000318188900003
Keywords in English human embryonic stem cells; cell cycle; culture adaptation; long-term culture
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 6. 8. 2013 16:59.
Abstract
Cell cycle represents not only a tightly orchestrated mechanism of cell replication and cell division but it also plays an important role in regulation of cell fate decision. Particularly in the context of pluripotent stem cells or multipotent progenitor cells, regulation of cell fate decision is of paramount importance. It has been shown that human embryonic stem cells (hESCs) show unique cell cycle characteristics, such as short doubling time due to abbreviated G1 phase; these properties change with the onset of differentiation. This review summarizes the current understanding of cell cycle regulation in hESCs. We discuss cell cycle properties as well as regulatory machinery governing cell cycle progression of undifferentiated hESCs. Additionally, we provide evidence that long-term culture of hESCs is accompanied by changes in cell cycle properties as well as configuration of several cell cycle regulatory molecules.
Links
GAP301/10/1971, research and development projectName: Exprese, signalizace a funkce receptorů smrti v lidských embryonálních kmenových buňkách.
Investor: Czech Science Foundation
MSM0021622430, plan (intention)Name: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie
Investor: Ministry of Education, Youth and Sports of the CR, Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
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