| BÁRTA, Tomáš, Dáša DOLEŽALOVÁ, Zuzana HOLUBCOVÁ and Aleš HAMPL. Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture. Experimental Biology and Medicine. LONDON: Mayvood, 2013, vol. 238, No 3, p. 271-275. ISSN 1535-3702. doi:10.1177/1535370213480711. |
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@article{1115210,
author = {Bárta, Tomáš and Doležalová, Dáša and Holubcová, Zuzana and Hampl, Aleš},
article_location = {LONDON},
article_number = {3},
doi = {http://dx.doi.org/10.1177/1535370213480711},
keywords = {human embryonic stem cells; cell cycle; culture adaptation; long-term culture},
language = {eng},
issn = {1535-3702},
journal = {Experimental Biology and Medicine},
title = {Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture},
volume = {238},
year = {2013}
}
TY - JOUR
ID - 1115210
AU - Bárta, Tomáš - Doležalová, Dáša - Holubcová, Zuzana - Hampl, Aleš
PY - 2013
TI - Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture
JF - Experimental Biology and Medicine
VL - 238
IS - 3
SP - 271-275
EP - 271-275
PB - Mayvood
SN - 15353702
KW - human embryonic stem cells
KW - cell cycle
KW - culture adaptation
KW - long-term culture
N2 - Cell cycle represents not only a tightly orchestrated mechanism of cell replication and cell division but it also plays an important role in regulation of cell fate decision. Particularly in the context of pluripotent stem cells or multipotent progenitor cells, regulation of cell fate decision is of paramount importance. It has been shown that human embryonic stem cells (hESCs) show unique cell cycle characteristics, such as short doubling time due to abbreviated G1 phase; these properties change with the onset of differentiation. This review summarizes the current understanding of cell cycle regulation in hESCs. We discuss cell cycle properties as well as regulatory machinery governing cell cycle progression of undifferentiated hESCs. Additionally, we provide evidence that long-term culture of hESCs is accompanied by changes in cell cycle properties as well as configuration of several cell cycle regulatory molecules.
ER -
BÁRTA, Tomáš, Dáša DOLEŽALOVÁ, Zuzana HOLUBCOVÁ and Aleš HAMPL. Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture. \textit{Experimental Biology and Medicine}. LONDON: Mayvood, 2013, vol.~238, No~3, p.~271-275. ISSN~1535-3702. doi:10.1177/1535370213480711.
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