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@article{1115298, author = {Procházková, Dagmar and Jarkovský, Jiří and Vinohradská, Hana and Konečná, Petra and Machačová, Lucie and Doležel, Zdeněk}, article_location = {Totowa}, article_number = {2}, doi = {http://dx.doi.org/10.1007/s12011-013-9724-6}, keywords = {hyperphenylalaninemia; phenylketonuria; pre-albumin; selenium; zinc; iron}, language = {eng}, issn = {0163-4984}, journal = {Biological Trace Element Research}, title = {Controlled diet in phenylketonuria and hyperphenylalaninemia may cause serum selenium deficiency in adult patients: the Czech experience}, url = {http://www.springer.com}, volume = {154}, year = {2013} }
TY - JOUR ID - 1115298 AU - Procházková, Dagmar - Jarkovský, Jiří - Vinohradská, Hana - Konečná, Petra - Machačová, Lucie - Doležel, Zdeněk PY - 2013 TI - Controlled diet in phenylketonuria and hyperphenylalaninemia may cause serum selenium deficiency in adult patients: the Czech experience JF - Biological Trace Element Research VL - 154 IS - 2 SP - 178-184 EP - 178-184 PB - Humana Press SN - 01634984 KW - hyperphenylalaninemia KW - phenylketonuria KW - pre-albumin KW - selenium KW - zinc KW - iron UR - http://www.springer.com N2 - Phenylketonuria is an inherited disorder of metabolism of the amino acid phenylalanine caused by a deficit of the enzyme phenylalanine hydroxylase. It is treated with a low-protein diet containing a low content of phenylalanine to prevent mental affection of the patient. Because of the restricted intake of high-biologic-value protein, patients with phenylketonuria may have lower than normal serum concentrations of pre-albumin, selenium, zinc and iron. The objective of the present study was to assess the compliance of our phenylketonuric (PKU) and hyperphenylalaninemic (HPA) patients; to determine the concentration of serum pre-albumin, selenium, zinc and iron to discover the potential correlation between the amount of proteins in food and their metabolic control. We studied 174 patients of which 113 were children (age 1-18), 60 with PKU and 53 with HPA and 61 were adults (age 18-42), 51 with PKU and 10 with HPA. We did not prove a statistically significant difference in the concentration of serum pre-albumin, zinc and iron among the respective groups. We proved statistically significant difference in serum selenium concentrations of adult PKU and HPA patients (p=0.006; Mann-Whitney U test). These results suggest that controlled low-protein diet in phenylketonuria and hyperphenylalaninemia may cause serum selenium deficiency in adult patients. ER -
PROCHÁZKOVÁ, Dagmar, Jiří JARKOVSKÝ, Hana VINOHRADSKÁ, Petra KONEČNÁ, Lucie MACHAČOVÁ a Zdeněk DOLEŽEL. Controlled diet in phenylketonuria and hyperphenylalaninemia may cause serum selenium deficiency in adult patients: the Czech experience. \textit{Biological Trace Element Research}. Totowa: Humana Press, roč.~154, č.~2, s.~178-184. ISSN~0163-4984. doi:10.1007/s12011-013-9724-6. 2013.
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