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Synthesis, activity and interaction of nitrone functionalized PAH derivatives

POTÁČEK, Milan, Marian BUCHLOVIČ, Zdeněk KŘÍŽ and Ctirad HOFR

Basic information

Original name

Synthesis, activity and interaction of nitrone functionalized PAH derivatives

Authors

POTÁČEK, Milan (203 Czech Republic, guarantor, belonging to the institution), Marian BUCHLOVIČ (703 Slovakia), Zdeněk KŘÍŽ (203 Czech Republic, belonging to the institution) and Ctirad HOFR (203 Czech Republic)

Edition

2013

Other information

Language

English

Type of outcome

Vyžádané přednášky

Field of Study

10401 Organic chemistry

Country of publisher

Latvia

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/13:00066251

Organization unit

Faculty of Science

Keywords in English

nitrone; PAH substitution; molecular modeling; activity testing in vitro;
Změněno: 19/7/2013 08:44, prof. RNDr. Milan Potáček, CSc.

Abstract

V originále

Polycyclic aromatic hydrocarbons (PAHs) are widely studied. Their carcinogenic properties are well known. In a sharp contrast to those effects the functionalized PAHs were recently identified as important candidates for cancer therapy.1 Mechanism of action is often simplified and studied at the DNA level. A lot of discussion has been held about groups being introduced to the PAHs structure. Novel approach to functionalized polycyclic aromatic hydrocarbons (PAHs) is presented. According to our experience in nitrone chemistry2 the synthetic design of new PAHs derivatives was achieved by a multicomponent reaction of compounds 1-3.

Links

GA203/09/1345, research and development project
Name: Allenový synthon v přípravě heterocyklických sloučenin
Investor: Czech Science Foundation, Allenyl synthon in synthesis of heterocyclic compounds