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@article{1116739,
author = {Mlčochová, Jitka and Faltejsková, Petra and Němeček, Radim and Svoboda, Marek and Slabý, Ondřej},
article_number = {10},
doi = {http://dx.doi.org/10.1007/s00432-013-1470-9},
keywords = {MicroRNA; Colorectal cancer; EGFR signalling pathway; Predictive biomarkers; Prognostic biomarkers},
language = {eng},
issn = {0171-5216},
journal = {Journal of cancer research and clinical oncology},
title = {MicroRNAs targeting EGFR signalling pathway in colorectal cancer},
url = {http://link.springer.com/article/10.1007%2Fs00432-013-1470-9},
volume = {139},
year = {2013}
}
TY - JOUR
ID - 1116739
AU - Mlčochová, Jitka - Faltejsková, Petra - Němeček, Radim - Svoboda, Marek - Slabý, Ondřej
PY - 2013
TI - MicroRNAs targeting EGFR signalling pathway in colorectal cancer
JF - Journal of cancer research and clinical oncology
VL - 139
IS - 10
SP - 1615-1624
EP - 1615-1624
PB - Springer-Verlag
SN - 01715216
KW - MicroRNA
KW - Colorectal cancer
KW - EGFR signalling pathway
KW - Predictive biomarkers
KW - Prognostic biomarkers
UR - http://link.springer.com/article/10.1007%2Fs00432-013-1470-9
L2 - http://link.springer.com/article/10.1007%2Fs00432-013-1470-9
N2 - MicroRNAs (miRNAs) are short, 18–25- nucleotide long, non-coding single-stranded RNAs, which are capable to regulate gene expression on post-transcrip- tional level through binding to their target protein-encoding mRNAs. miRNAs regulate individual components of multiple oncogenic pathways. One of them is epidermal growth factor receptor (EGFR) signalling pathway that regulates cell proliferation, differentiation, migration, angiogenesis and apoptosis. All these processes are deregulated in colorectal cancer (CRC). Moreover, EGFR has been validated as the therapeutic target in CRC, and monoclonal antibodies cetuximab and panitumumab are used in the therapy of patients with metastatic CRC. Because of the extensive involvement of miRNAs in the regulation of EGFR signalling, it seems they could also serve as promising predictive biomarkers to anti-EGFR therapy. In this review, we summarize current knowledge about miRNAs targeting EGFR signalling pathway, their functioning in CRC pathogenesis and potential usage as biomarkers.
ER -
MLČOCHOVÁ, Jitka, Petra FALTEJSKOVÁ, Radim NĚMEČEK, Marek SVOBODA and Ondřej SLABÝ. MicroRNAs targeting EGFR signalling pathway in colorectal cancer. \textit{Journal of cancer research and clinical oncology}. Springer-Verlag, 2013, vol.~139, No~10, p.~1615-1624. ISSN~0171-5216. Available from: https://dx.doi.org/10.1007/s00432-013-1470-9.
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