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@article{1117953,
author = {Májek, Ondřej and Gondos, Adam and Jansen, Lina and Emrich, Katharina and Holleczek, Bernd and Katalinic, Alexander and Nennecke, Alice and Eberle, Andrea and Brenner, Hermann},
article_location = {San Francisco},
article_number = {7},
doi = {http://dx.doi.org/10.1371/journal.pone.0068077},
keywords = {HORMONE REPLACEMENT THERAPY; LONG-TERM SURVIVAL; UP-TO-DATE; GENDER INFLUENCES TREATMENT; EUROCARE HIGH-RESOLUTION; PERIOD ANALYSIS; RELATIVE SURVIVAL; POSTMENOPAUSAL WOMEN; EARLY 21ST-CENTURY; COLON-CANCER},
language = {eng},
issn = {1932-6203},
journal = {PLoS One},
note = {Article Number: e68077},
title = {Sex Differences in Colorectal Cancer Survival: Population-Based Analysis of 164,996 Colorectal Cancer Patients in Germany},
url = {http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0068077},
volume = {8},
year = {2013}
}
TY - JOUR
ID - 1117953
AU - Májek, Ondřej - Gondos, Adam - Jansen, Lina - Emrich, Katharina - Holleczek, Bernd - Katalinic, Alexander - Nennecke, Alice - Eberle, Andrea - Brenner, Hermann
PY - 2013
TI - Sex Differences in Colorectal Cancer Survival: Population-Based Analysis of 164,996 Colorectal Cancer Patients in Germany
JF - PLoS One
VL - 8
IS - 7
SP - e68077
EP - e68077
PB - Public Library of Science
SN - 19326203
N1 - Article Number: e68077
KW - HORMONE REPLACEMENT THERAPY
KW - LONG-TERM SURVIVAL
KW - UP-TO-DATE
KW - GENDER INFLUENCES TREATMENT
KW - EUROCARE HIGH-RESOLUTION
KW - PERIOD ANALYSIS
KW - RELATIVE SURVIVAL
KW - POSTMENOPAUSAL WOMEN
KW - EARLY 21ST-CENTURY
KW - COLON-CANCER
UR - http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0068077
N2 - Risk of colorectal cancer (CRC) is considerably higher in men compared to women; however, there is inconclusive evidence of sex differences in CRC prognosis. We aimed to assess and explain sex differences in 5-year relative survival using standard and model-based period analysis among 164,996 patients diagnosed with CRC from 1997 to 2006 and reported to 11 German cancer registries covering a population of 33 million inhabitants. Age-adjusted 5-year relative survival was higher in women (64.5% vs. 61.9%, P<0.0001). A substantial survival advantage of women was confirmed in multivariate analysis after adjusting for CRC stage and subsite in subjects under 65 years of age (relative excess risk, RER 0.86, 95% CI 0.82-0.90), but not in older subjects (RER 1.01, 95% CI 0.98-1.04); this pattern was similar in the 1st and in the 2nd to 5th year after diagnosis. The survival advantage of women varied by CRC stage and age and was most pronounced for localized disease (RERs 0.59-0.88 in various age subgroups) and in patients under 45 years of age (RERs 0.59, 0.72 and 0.76 in patients with localized, regional or advanced disease, respectively). On the contrary, sex differences in survival did not vary by location of CRC. In conclusion, our large population-based study confirmed a survival advantage of female compared to male CRC patients, most notably in young and middle aged patients and patients with localized disease. The effect of sex hormones, either endogenous or through hormonal replacement therapy, might be the most plausible explanation for the observed patterns.
ER -
MÁJEK, Ondřej, Adam GONDOS, Lina JANSEN, Katharina EMRICH, Bernd HOLLECZEK, Alexander KATALINIC, Alice NENNECKE, Andrea EBERLE and Hermann BRENNER. Sex Differences in Colorectal Cancer Survival: Population-Based Analysis of 164,996 Colorectal Cancer Patients in Germany. \textit{PLoS One}. San Francisco: Public Library of Science, 2013, vol.~8, No~7, p.~e68077, 7 pp. ISSN~1932-6203. doi:10.1371/journal.pone.0068077.
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