MÁJEK, Ondřej, Adam GONDOS, Lina JANSEN, Katharina EMRICH, Bernd HOLLECZEK, Alexander KATALINIC, Alice NENNECKE, Andrea EBERLE and Hermann BRENNER. Sex Differences in Colorectal Cancer Survival: Population-Based Analysis of 164,996 Colorectal Cancer Patients in Germany. PLoS One. San Francisco: Public Library of Science, 2013, vol. 8, No 7, p. e68077, 7 pp. ISSN 1932-6203. doi:10.1371/journal.pone.0068077.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name Sex Differences in Colorectal Cancer Survival: Population-Based Analysis of 164,996 Colorectal Cancer Patients in Germany
Authors MÁJEK, Ondřej (203 Czech Republic, guarantor, belonging to the institution), Adam GONDOS (276 Germany), Lina JANSEN (276 Germany), Katharina EMRICH (276 Germany), Bernd HOLLECZEK (276 Germany), Alexander KATALINIC (276 Germany), Alice NENNECKE (276 Germany), Andrea EBERLE (276 Germany) and Hermann BRENNER (276 Germany).
Edition PLoS One, San Francisco, Public Library of Science, 2013, 1932-6203.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 3.534
RIV identification code RIV/00216224:14110/13:00068950
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1371/journal.pone.0068077
UT WoS 000321425300040
Keywords in English HORMONE REPLACEMENT THERAPY; LONG-TERM SURVIVAL; UP-TO-DATE; GENDER INFLUENCES TREATMENT; EUROCARE HIGH-RESOLUTION; PERIOD ANALYSIS; RELATIVE SURVIVAL; POSTMENOPAUSAL WOMEN; EARLY 21ST-CENTURY; COLON-CANCER
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 13. 11. 2013 13:44.
Abstract
Risk of colorectal cancer (CRC) is considerably higher in men compared to women; however, there is inconclusive evidence of sex differences in CRC prognosis. We aimed to assess and explain sex differences in 5-year relative survival using standard and model-based period analysis among 164,996 patients diagnosed with CRC from 1997 to 2006 and reported to 11 German cancer registries covering a population of 33 million inhabitants. Age-adjusted 5-year relative survival was higher in women (64.5% vs. 61.9%, P<0.0001). A substantial survival advantage of women was confirmed in multivariate analysis after adjusting for CRC stage and subsite in subjects under 65 years of age (relative excess risk, RER 0.86, 95% CI 0.82-0.90), but not in older subjects (RER 1.01, 95% CI 0.98-1.04); this pattern was similar in the 1st and in the 2nd to 5th year after diagnosis. The survival advantage of women varied by CRC stage and age and was most pronounced for localized disease (RERs 0.59-0.88 in various age subgroups) and in patients under 45 years of age (RERs 0.59, 0.72 and 0.76 in patients with localized, regional or advanced disease, respectively). On the contrary, sex differences in survival did not vary by location of CRC. In conclusion, our large population-based study confirmed a survival advantage of female compared to male CRC patients, most notably in young and middle aged patients and patients with localized disease. The effect of sex hormones, either endogenous or through hormonal replacement therapy, might be the most plausible explanation for the observed patterns.
Links
MUNI/A/0828/2011, interní kód MUName: Matematické a statistické modely v hodnocení výsledků programů screeningu zhoubných nádorů (Acronym: SCREENMOD)
Investor: Masaryk University, Category A
PrintDisplayed: 27. 6. 2022 20:32