Role of platelet chemokines, PF-4 and CTAP-III, in cancer
biology

J 2013

Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology

PILÁTOVÁ, Kateřina, Kristína GREPLOVÁ, Regina DEMLOVÁ, Beatrix BENCSIKOVÁ, Giannoula Lakka KLEMENT et. al.

Basic information

Original name

Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology

Authors

PILÁTOVÁ, Kateřina (203 Czech Republic, belonging to the institution), Kristína GREPLOVÁ (203 Czech Republic, belonging to the institution), Regina DEMLOVÁ (203 Czech Republic, belonging to the institution), Beatrix BENCSIKOVÁ (703 Slovakia, belonging to the institution), Giannoula Lakka KLEMENT (840 United States of America) and Lenka ZDRAŽILOVÁ DUBSKÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Journal of Hematology & Oncology, LONDON, BIOMED CENTRAL LTD, 2013, 1756-8722

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.933

RIV identification code

RIV/00216224:14110/13:00069034

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1186/1756-8722-6-42

UT WoS

000321009900001

Keywords in English

Platelet; PF-4; CTAP-III; Cancer; Angiogenesis; IL-8; Inflammation

Abstract

V originále

With the recent addition of anti-angiogenic agents to cancer treatment, the angiogenesis regulators in platelets are gaining importance. Platelet factor 4 (PF-4/CXCL4) and Connective tissue activating peptide III (CTAP-III) are two platelet-associated chemokines that modulate tumor angiogenesis, inflammation within the tumor microenvironment, and in turn tumor growth. Here, we review the role of PF-4 and CTAP-III in the regulation of tumor angiogenesis; the results of clinical trial using recombinant PF-4 (rPF-4); and the use of PF-4 and CTAP-III as cancer biomarkers.

Citovat

PILÁTOVÁ, Kateřina, Kristína GREPLOVÁ, Regina DEMLOVÁ, Beatrix BENCSIKOVÁ, Giannoula Lakka KLEMENT and Lenka ZDRAŽILOVÁ DUBSKÁ. Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology. Journal of Hematology & Oncology. LONDON: BIOMED CENTRAL LTD, 2013, vol. 6, No 42, p. 1-8. ISSN 1756-8722. Available from: https://dx.doi.org/10.1186/1756-8722-6-42.

@article{1119471,
   author = {Pilátová, Kateřina and Greplová, Kristína and Demlová, Regina and Bencsiková, Beatrix and Klement, Giannoula Lakka and Zdražilová Dubská, Lenka},
   article_location = {LONDON},
   article_number = {42},
   doi = {http://dx.doi.org/10.1186/1756-8722-6-42},
   keywords = {Platelet; PF-4; CTAP-III; Cancer; Angiogenesis; IL-8; Inflammation},
   language = {eng},
   issn = {1756-8722},
   journal = {Journal of Hematology & Oncology},
   title = {Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology},
   url = {http://www.jhoonline.org/content/6/1/42},
   volume = {6},
   year = {2013}
}

TY  - JOUR
ID  - 1119471
AU  - Pilátová, Kateřina - Greplová, Kristína - Demlová, Regina - Bencsiková, Beatrix - Klement, Giannoula Lakka - Zdražilová Dubská, Lenka
PY  - 2013
TI  - Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology
JF  - Journal of Hematology & Oncology
VL  - 6
IS  - 42
SP  - 1-8
EP  - 1-8
PB  - BIOMED CENTRAL LTD
SN  - 17568722
KW  - Platelet
KW  - PF-4
KW  - CTAP-III
KW  - Cancer
KW  - Angiogenesis
KW  - IL-8
KW  - Inflammation
UR  - http://www.jhoonline.org/content/6/1/42
N2  - With the recent addition of anti-angiogenic agents to cancer treatment, the angiogenesis regulators in platelets are gaining importance. Platelet factor 4 (PF-4/CXCL4) and Connective tissue activating peptide III (CTAP-III) are two platelet-associated chemokines that modulate tumor angiogenesis, inflammation within the tumor microenvironment, and in turn tumor growth. Here, we review the role of PF-4 and CTAP-III in the regulation of tumor angiogenesis; the results of clinical trial using recombinant PF-4 (rPF-4); and the use of PF-4 and CTAP-III as cancer biomarkers.
ER  -

PILÁTOVÁ, Kateřina, Kristína GREPLOVÁ, Regina DEMLOVÁ, Beatrix BENCSIKOVÁ, Giannoula Lakka KLEMENT and Lenka ZDRAŽILOVÁ DUBSKÁ. Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology. \textit{Journal of Hematology \&{} Oncology}. LONDON: BIOMED CENTRAL LTD, 2013, vol.~6, No~42, p.~1-8. ISSN~1756-8722. Available from: https://dx.doi.org/10.1186/1756-8722-6-42.

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