J 2012

Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins - A Review

ŠKUTKOVÁ, Helena, Petr BABULA, Marie STIBOROVA, Tomáš ECKSCHLAGER, Libuše TRNKOVÁ et. al.

Basic information

Original name

Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins - A Review

Authors

ŠKUTKOVÁ, Helena, Petr BABULA, Marie STIBOROVA, Tomáš ECKSCHLAGER, Libuše TRNKOVÁ, Ivo PROVAZNIK, Jaromír HUBÁLEK, René KIZEK and Vojtech ADAM

Edition

International Journal of Electrochemical Science, 2012, 1452-3981

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10403 Physical chemistry

Country of publisher

Serbia

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.729 in 2011

Organization unit

Faculty of Science

UT WoS

000312936700062

Keywords in English

Metallothionein; Isoforms; Bioinformatics; Data Analysis; Phylogeny; DNA Sequencing; Electrochemistry; Voltammetry; Brdicka Reaction; Peak H
Změněno: 20/8/2013 10:08, Mgr. Sylvie Dohnalíková

Abstract

V originále

Mammalian metallothioneins (MTs) are cysteine-rich low-molecular mass proteins with numerous functions including toxic metal detoxification, as a metal chaperone and maintenance of metal ion homeostasis. Four major isoforms (MT-1 through MT-4) have been identified in mammals. In this review, the functions of the isoforms are summarized. Moreover, polymorphisms of MTs genes and their connection with cancerogenesis and cancer diagnostics are described. The interesting properties of MTs are closely related with structure, which can be studied by modern bioinformatics approaches and electrochemical methods. The advantages of the mentioned approaches and methods are discussed.