ŠKUTKOVÁ, Helena, Petr BABULA, Marie STIBOROVA, Tomáš ECKSCHLAGER, Libuše TRNKOVÁ, Ivo PROVAZNIK, Jaromír HUBÁLEK, René KIZEK and Vojtech ADAM. Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins - A Review. International Journal of Electrochemical Science. 2012, vol. 7, No 12, p. 12415-12431. ISSN 1452-3981.
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Basic information
Original name Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins - A Review
Authors ŠKUTKOVÁ, Helena, Petr BABULA, Marie STIBOROVA, Tomáš ECKSCHLAGER, Libuše TRNKOVÁ, Ivo PROVAZNIK, Jaromír HUBÁLEK, René KIZEK and Vojtech ADAM.
Edition International Journal of Electrochemical Science, 2012, 1452-3981.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10403 Physical chemistry
Country of publisher Serbia
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.729 in 2011
Organization unit Faculty of Science
UT WoS 000312936700062
Keywords in English Metallothionein; Isoforms; Bioinformatics; Data Analysis; Phylogeny; DNA Sequencing; Electrochemistry; Voltammetry; Brdicka Reaction; Peak H
Changed by Changed by: Mgr. Sylvie Dohnalíková, učo 150911. Changed: 20/8/2013 10:08.
Abstract
Mammalian metallothioneins (MTs) are cysteine-rich low-molecular mass proteins with numerous functions including toxic metal detoxification, as a metal chaperone and maintenance of metal ion homeostasis. Four major isoforms (MT-1 through MT-4) have been identified in mammals. In this review, the functions of the isoforms are summarized. Moreover, polymorphisms of MTs genes and their connection with cancerogenesis and cancer diagnostics are described. The interesting properties of MTs are closely related with structure, which can be studied by modern bioinformatics approaches and electrochemical methods. The advantages of the mentioned approaches and methods are discussed.
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