ŠKUTKOVÁ, Helena, Petr BABULA, Marie STIBOROVA, Tomáš ECKSCHLAGER, Libuše TRNKOVÁ, Ivo PROVAZNIK, Jaromír HUBÁLEK, René KIZEK and Vojtech ADAM. Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins - A Review. International Journal of Electrochemical Science. 2012, vol. 7, No 12, p. 12415-12431. ISSN 1452-3981. |
Other formats:
BibTeX
LaTeX
RIS
@article{1119877, author = {Škutková, Helena and Babula, Petr and Stiborova, Marie and Eckschlager, Tomáš and Trnková, Libuše and Provaznik, Ivo and Hubálek, Jaromír and Kizek, René and Adam, Vojtech}, article_number = {12}, keywords = {Metallothionein; Isoforms; Bioinformatics; Data Analysis; Phylogeny; DNA Sequencing; Electrochemistry; Voltammetry; Brdicka Reaction; Peak H}, language = {eng}, issn = {1452-3981}, journal = {International Journal of Electrochemical Science}, title = {Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins - A Review}, volume = {7}, year = {2012} }
TY - JOUR ID - 1119877 AU - Škutková, Helena - Babula, Petr - Stiborova, Marie - Eckschlager, Tomáš - Trnková, Libuše - Provaznik, Ivo - Hubálek, Jaromír - Kizek, René - Adam, Vojtech PY - 2012 TI - Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins - A Review JF - International Journal of Electrochemical Science VL - 7 IS - 12 SP - 12415-12431 EP - 12415-12431 SN - 14523981 KW - Metallothionein KW - Isoforms KW - Bioinformatics KW - Data Analysis KW - Phylogeny KW - DNA Sequencing KW - Electrochemistry KW - Voltammetry KW - Brdicka Reaction KW - Peak H N2 - Mammalian metallothioneins (MTs) are cysteine-rich low-molecular mass proteins with numerous functions including toxic metal detoxification, as a metal chaperone and maintenance of metal ion homeostasis. Four major isoforms (MT-1 through MT-4) have been identified in mammals. In this review, the functions of the isoforms are summarized. Moreover, polymorphisms of MTs genes and their connection with cancerogenesis and cancer diagnostics are described. The interesting properties of MTs are closely related with structure, which can be studied by modern bioinformatics approaches and electrochemical methods. The advantages of the mentioned approaches and methods are discussed. ER -
ŠKUTKOVÁ, Helena, Petr BABULA, Marie STIBOROVA, Tomáš ECKSCHLAGER, Libuše TRNKOVÁ, Ivo PROVAZNIK, Jaromír HUBÁLEK, René KIZEK and Vojtech ADAM. Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins - A Review. \textit{International Journal of Electrochemical Science}. 2012, vol.~7, No~12, p.~12415-12431. ISSN~1452-3981.
|