Dystonia and the cerebellum: A new field of interest in
movement disorders?

J 2013

Dystonia and the cerebellum: A new field of interest in movement disorders?

FILIP, Pavel, Ovidiu V LUNGU and Martin BAREŠ

Basic information

Original name

Dystonia and the cerebellum: A new field of interest in movement disorders?

Authors

FILIP, Pavel (703 Slovakia, belonging to the institution), Ovidiu V LUNGU (124 Canada) and Martin BAREŠ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Clinical Neurophysiology, Clare, Elsevier Ireland, 2013, 1388-2457

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.979

RIV identification code

RIV/00216224:14740/13:00065623

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1016/j.clinph.2013.01.003

UT WoS

000321488200006

Keywords in English

Cerebellum; Dystonia; Animal models; Imaging; Pathophysiology

Abstract

V originále

Although dystonia has traditionally been regarded as a basal ganglia dysfunction, recent provocative evidence has emerged of cerebellar involvement in the pathophysiology of this enigmatic disease. This review synthesizes the data suggesting that the cerebellum plays an important role in dystonia etiology, from neuroanatomical research of complex networks showing that the cerebellum is connected to a wide range of other central nervous system structures involved in movement control to animal models indicating that signs of dystonia are due to cerebellum dysfunction and completely disappear after cerebellectomy, and finally to clinical observations in secondary dystonia patients with various types of cerebellar lesions. We propose that dystonia is a large-scale dysfunction, involving not only cortico-basal ganglia-thalamo-cortical pathways, but the cortico-ponto-cerebello-thalamo-cortical loop as well. Even in the absence of traditional "cerebellar signs" in most dystonia patients, there are more subtle indications of cerebellar dysfunction. It is clear that as long as the cerebellum's role in dystonia genesis remains unexamined, it will be difficult to significantly improve the current standards of dystonia treatment or to provide curative treatment.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

NT13437, research and development project

Name: Mozeček, kognitivní dysfunkce a mechanismy kontroly pohybu a odhadu času u dystonie a schizofrenie.

Citovat

FILIP, Pavel, Ovidiu V LUNGU and Martin BAREŠ. Dystonia and the cerebellum: A new field of interest in movement disorders? Clinical Neurophysiology. Clare: Elsevier Ireland, 2013, vol. 124, No 7, p. 1269-1276. ISSN 1388-2457. Available from: https://dx.doi.org/10.1016/j.clinph.2013.01.003.

@article{1120449,
   author = {Filip, Pavel and Lungu, Ovidiu V and Bareš, Martin},
   article_location = {Clare},
   article_number = {7},
   doi = {http://dx.doi.org/10.1016/j.clinph.2013.01.003},
   keywords = {Cerebellum; Dystonia; Animal models; Imaging; Pathophysiology},
   language = {eng},
   issn = {1388-2457},
   journal = {Clinical Neurophysiology},
   title = {Dystonia and the cerebellum: A new field of interest in movement disorders?},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/23422326},
   volume = {124},
   year = {2013}
}

TY  - JOUR
ID  - 1120449
AU  - Filip, Pavel - Lungu, Ovidiu V - Bareš, Martin
PY  - 2013
TI  - Dystonia and the cerebellum: A new field of interest in movement disorders?
JF  - Clinical Neurophysiology
VL  - 124
IS  - 7
SP  - 1269-1276
EP  - 1269-1276
PB  - Elsevier Ireland
SN  - 13882457
KW  - Cerebellum
KW  - Dystonia
KW  - Animal models
KW  - Imaging
KW  - Pathophysiology
UR  - http://www.ncbi.nlm.nih.gov/pubmed/23422326
L2  - http://www.ncbi.nlm.nih.gov/pubmed/23422326
N2  - Although dystonia has traditionally been regarded as a basal ganglia dysfunction, recent provocative evidence has emerged of cerebellar involvement in the pathophysiology of this enigmatic disease. This review synthesizes the data suggesting that the cerebellum plays an important role in dystonia etiology, from neuroanatomical research of complex networks showing that the cerebellum is connected to a wide range of other central nervous system structures involved in movement control to animal models indicating that signs of dystonia are due to cerebellum dysfunction and completely disappear after cerebellectomy, and finally to clinical observations in secondary dystonia patients with various types of cerebellar lesions. We propose that dystonia is a large-scale dysfunction, involving not only cortico-basal ganglia-thalamo-cortical pathways, but the cortico-ponto-cerebello-thalamo-cortical loop as well. Even in the absence of traditional "cerebellar signs" in most dystonia patients, there are more subtle indications of cerebellar dysfunction. It is clear that as long as the cerebellum's role in dystonia genesis remains unexamined, it will be difficult to significantly improve the current standards of dystonia treatment or to provide curative treatment.
ER  -

FILIP, Pavel, Ovidiu V LUNGU and Martin BAREŠ. Dystonia and the cerebellum: A new field of interest in movement disorders? \textit{Clinical Neurophysiology}. Clare: Elsevier Ireland, 2013, vol.~124, No~7, p.~1269-1276. ISSN~1388-2457. Available from: https://dx.doi.org/10.1016/j.clinph.2013.01.003.

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