Dystonia and the cerebellum: A new field of interest in movement disorders?

FILIP, Pavel, Ovidiu V LUNGU and Martin BAREŠ. Dystonia and the cerebellum: A new field of interest in movement disorders? Clinical Neurophysiology. Clare: Elsevier Ireland, 2013, vol. 124, No 7, p. 1269-1276. ISSN 1388-2457. Available from: https://dx.doi.org/10.1016/j.clinph.2013.01.003.

Basic information

• Original name: Dystonia and the cerebellum: A new field of interest in movement disorders?
• Authors: FILIP, Pavel (703 Slovakia, belonging to the institution), Ovidiu V LUNGU (124 Canada) and Martin BAREŠ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Clinical Neurophysiology, Clare, Elsevier Ireland, 2013, 1388-2457.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 2.979
• RIV identification code: RIV/00216224:14740/13:00065623
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1016/j.clinph.2013.01.003
• UT WoS: 000321488200006
• Keywords in English: Cerebellum; Dystonia; Animal models; Imaging; Pathophysiology
• Tags: ok, rivok
• Tags: International impact, Reviewed

Abstract

Although dystonia has traditionally been regarded as a basal ganglia dysfunction, recent provocative evidence has emerged of cerebellar involvement in the pathophysiology of this enigmatic disease. This review synthesizes the data suggesting that the cerebellum plays an important role in dystonia etiology, from neuroanatomical research of complex networks showing that the cerebellum is connected to a wide range of other central nervous system structures involved in movement control to animal models indicating that signs of dystonia are due to cerebellum dysfunction and completely disappear after cerebellectomy, and finally to clinical observations in secondary dystonia patients with various types of cerebellar lesions. We propose that dystonia is a large-scale dysfunction, involving not only cortico-basal ganglia-thalamo-cortical pathways, but the cortico-ponto-cerebello-thalamo-cortical loop as well. Even in the absence of traditional "cerebellar signs" in most dystonia patients, there are more subtle indications of cerebellar dysfunction. It is clear that as long as the cerebellum's role in dystonia genesis remains unexamined, it will be difficult to significantly improve the current standards of dystonia treatment or to provide curative treatment.

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology
• NT13437, research and development project: Name: Mozeček, kognitivní dysfunkce a mechanismy kontroly pohybu a odhadu času u dystonie a schizofrenie.