BERNARD, Vladan, Vojtěch MORNSTEIN a Aleš BOUREK. Effect of near field ultrasound on carboplatin treatment of ovarian carcinoma cells. Indian Journal of Biochemistry & Biophysics. India: National Institute of Science Communicat, 2013, roč. 50, č. 4, s. 284-288. ISSN 0301-1208.
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Základní údaje
Originální název Effect of near field ultrasound on carboplatin treatment of ovarian carcinoma cells
Autoři BERNARD, Vladan (203 Česká republika, garant, domácí), Vojtěch MORNSTEIN (203 Česká republika, domácí) a Aleš BOUREK (203 Česká republika, domácí).
Vydání Indian Journal of Biochemistry & Biophysics, India, National Institute of Science Communicat, 2013, 0301-1208.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 10610 Biophysics
Stát vydavatele Česká republika
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 1.077
Kód RIV RIV/00216224:14110/13:00069140
Organizační jednotka Lékařská fakulta
UT WoS 000325058800006
Klíčová slova anglicky carboplatin;ultrasoun;viability
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Ing. Mgr. Věra Pospíšilíková, učo 9005. Změněno: 15. 4. 2014 15:55.
Anotace
It has long been shown that therapeutic ultrasound has the potential to affect cells surfaces and membranes. In this study, the effects of ultrasound in near field mode, the anti-cancer drug carboplatin and their combined application was studied on human carcinoma cells A2780. Four modes of treatment were used: exposure to ultrasonic field, application of carboplatin, exposure to ultrasound followed by carboplatin and carboplatin treatment followed by exposure to near field ultrasound. The value of viability was measured by standard MTT test. The value of ultrasound intensity was set 1 Wcm-2 and 1 MHz frequency was used. The real value of acoustic pressure during in vitro experiments was assessed by hydrophone. The results showed that a combined effect of ultrasound and carboplatin influenced the viability of human carcinoma cells A2780 more than the application of ultrasound or carboplatin alone. It could be assumed that exposure of cells to ultrasonic field had an immediate effect on the structure of cell surface and consequently on the entry of carboplatin into the cell. The results of our experiments demonstrated possibility of using therapeutic ultrasound in potentiating the cytostatic treatment of human carcinoma cells.
VytisknoutZobrazeno: 30. 6. 2022 16:11