Detailed Information on Publication Record

BITTNER, Michal, Nadine SAUL and Christian E W STEINBERG. Antiandrogenic activity of humic substances. Science of the Total Environment. AMSTERDAM: Elsevier, 2012, vol. 432, No 2012, p. 93-96. ISSN 0048-9697. Available from: https://dx.doi.org/10.1016/j.scitotenv.2012.05.056.

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Basic information
Original name	Antiandrogenic activity of humic substances
Authors	BITTNER, Michal (203 Czech Republic, belonging to the institution), Nadine SAUL (276 Germany) and Christian E W STEINBERG (276 Germany, guarantor).
Edition	Science of the Total Environment, AMSTERDAM, Elsevier, 2012, 0048-9697.

Other information
Original language	English
Type of outcome	Article in a journal
Field of Study	30304 Public and environmental health
Country of publisher	Netherlands
Confidentiality degree	is not subject to a state or trade secret
Impact factor	Impact factor: 3.258
RIV identification code	RIV/00216224:14310/12:00069145
Organization unit	Faculty of Science
Doi	http://dx.doi.org/10.1016/j.scitotenv.2012.05.056
UT WoS	000308270700010
Keywords in English	Humic substances; Hormone-like effect; Antiandrogenic pathway
Tags	AKR, rivok
Changed by	Changed by: RNDr. Mgr. Michal Bittner, Ph.D., učo 15440. Changed: 10/7/2017 13:25.

Abstract
For long, natural organic matter (NOM) composed mainly of humic substances (HS) were regarded as inert in the ecosystems with respect to their possible chemical interaction with exposed organisms. However recently, NOM have been shown to elicit various adverse effects generally attributed to synthetic xenobiotics, including estrogenic effects translating into shifts of the gender ratios in populations. However, the anti/androgenic pathway was not yet evaluated. Here, we applied an anti/androgenic sensitive cell line MDA stably transfected with the firefly luciferase gene under transcriptional control of the androgen responsive element. With five out of twelve tested NOM preparations, particularly with soil and coal isolates, we identified a relatively high, concentration-dependent antiandrogenic effect. This appears to be the first study to show this endocrine disrupting pathway for a ubiquitous biogeochemical matrix, a potential activity which should not be neglected in forthcoming studies on synthetic endocrine disruptors in the environment.

Abstract

For long, natural organic matter (NOM) composed mainly of humic substances (HS) were regarded as inert in the ecosystems with respect to their possible chemical interaction with exposed organisms. However recently, NOM have been shown to elicit various adverse effects generally attributed to synthetic xenobiotics, including estrogenic effects translating into shifts of the gender ratios in populations. However, the anti/androgenic pathway was not yet evaluated. Here, we applied an anti/androgenic sensitive cell line MDA stably transfected with the firefly luciferase gene under transcriptional control of the androgen responsive element. With five out of twelve tested NOM preparations, particularly with soil and coal isolates, we identified a relatively high, concentration-dependent antiandrogenic effect. This appears to be the first study to show this endocrine disrupting pathway for a ubiquitous biogeochemical matrix, a potential activity which should not be neglected in forthcoming studies on synthetic endocrine disruptors in the environment.

Links
ED0001/01/01, research and development project	Name: CETOCOEN
MSM0021622412, plan (intention)	Name: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Acronym: INCHEMBIOL)
MSM0021622412, plan (intention)	Investor: Ministry of Education, Youth and Sports of the CR, Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)