Detailed Information on Publication Record
2011
Using NMR spectroscopy for improvement of cisplatin-based drugs
ŠMIŘÁKOVÁ, Eliška, Paride PAPADIA, Fabio ARNESANO, Giovanni NATILE, Karel KUBÍČEK et. al.Basic information
Original name
Using NMR spectroscopy for improvement of cisplatin-based drugs
Authors
ŠMIŘÁKOVÁ, Eliška (203 Czech Republic, belonging to the institution), Paride PAPADIA (380 Italy), Fabio ARNESANO (380 Italy), Giovanni NATILE (380 Italy), Karel KUBÍČEK (203 Czech Republic, belonging to the institution) and Jiří KOZELKA (250 France, guarantor, belonging to the institution)
Edition
Instruments and methods for biology and medicine 2011, 2011
Other information
Language
English
Type of outcome
Konferenční abstrakt
Field of Study
10610 Biophysics
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14310/11:00069209
Organization unit
Faculty of Science
ISBN
978-80-01-04915-0
Keywords (in Czech)
cisplatina; nukleární magnetická rezonance; molekulárně-dynamické výpočty
Keywords in English
cisplatin; nuclear magnetic resonance; molecular dynamics simulations
Tags
International impact, Reviewed
Změněno: 9/9/2013 10:35, Mgr. Eliška Šmiřáková
Abstract
V originále
One of the aims of the present research is the development of new anticancer drugs by modifying the already known ones to increase their cytostatic activity while lowering the side-effects. The major goal of this project is to investigate the sequence selectivity of cisplatin-DNA interaction in order to understand the biochemical mechanism of cisplatin effect and consider the way to reduce its toxicity. To achieve this goal, we employed modern NMR methods, taking so the advantage of the fact that it is possible to study the biological compounds of interest in solution under nearly physiological conditions. In my contribution, I will show the structural properties of DNA 22-mer containing T4-loop crosslinked with cisplatin derivative RR-DACH. NMR data acquisition and processing as well as the determination of the structural models using molecular dynamics simulations will be presented.
Links
| MUNI/A/1046/2009, interní kód MU |
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