URBANEK, P., Michaela KREIDLOVÁ, Ladislav DUŠEK, R. BRUHA, Z. MARECEK and J. PETRTYL. Anemia as a predictor of response to antiviral therapy in chronic hepatitis C. Bratislava Medical Journal - Bratislavské lékarske listy. BRATISLAVA: Univerzita Komenského, 2013, vol. 114, No 4, p. 213-217. ISSN 0006-9248. doi:10.4149/BLL_2013_044.
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Basic information
Original name Anemia as a predictor of response to antiviral therapy in chronic hepatitis C
Authors URBANEK, P. (203 Czech Republic), Michaela KREIDLOVÁ (203 Czech Republic), Ladislav DUŠEK (203 Czech Republic, guarantor, belonging to the institution), R. BRUHA (203 Czech Republic), Z. MARECEK (203 Czech Republic) and J. PETRTYL (203 Czech Republic).
Edition Bratislava Medical Journal - Bratislavské lékarske listy, BRATISLAVA, Univerzita Komenského, 2013, 0006-9248.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10600 1.6 Biological sciences
Country of publisher Slovakia
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.446
RIV identification code RIV/00216224:14110/13:00069218
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.4149/BLL_2013_044
UT WoS 000318058700006
Keywords in English anemia; hepatitis C virus; pegylated interferon; ribavirin
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 9. 9. 2013 17:19.
Abstract
Background: The standard therapy for chronic HCV infection is the administration of pegylated interferons in combination with ribavirin. Anemia is a dose-dependent side-effect of ribavirin administration. The degree of anemia could be indicative of the individual exposure to ribavirin. Aims: 1) To evaluate the correlation of HGB level decreases at specified time-points with a sustained virological response during the antiviral treatment. 2) To compare these parameters with the virological predictors for responses. Methods: A retrospective analysis of cohort, which comprised 164 patients treated with standard therapy at a tertiary center in Prague, Czech Republic. Results: We identified several predictive factors for a sustained virological response in females: baseline HGB level <= 140 g/l (p=0.025), maximum drop from baseline >40 g (p=0.039), and a HGB drop in week 4 >30 g (p=0.044). There was only one predictor identified for males: reaching the lowest HGB level after week 19 (p=0.021). The strongest positive predictor of response was a rapid virological response. A low viral load (<600 000 IU/ml) at baseline was not associated with a sustained response in either gender. Conclusions: The parameters of HGB decrease during antiviral treatment are better correlated with a sustained response in females. None of these response predicting parameters was as significant as that of rapid virological response as that of rapid virological response (Tab. 4, Fig. 1, Ref. 15).
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