| NAVRÁTILOVÁ, Jarmila, Tereza HANKEOVÁ, Petr BENEŠ and Jan ŠMARDA. Acidic pH of tumor microenvironment enhances cytotoxicity of disulfiram/Cu2+ complex to breast and colon cancer cells. CHEMOTHERAPY. Basel, Switzerland: S. KARGER AG, Basel, 2013, vol. 2013, No 59, p. 112-120. ISSN 0009-3157. Available from: https://dx.doi.org/10.1159/000353915. |
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@article{1122524,
author = {Navrátilová, Jarmila and Hankeová, Tereza and Beneš, Petr and Šmarda, Jan},
article_location = {Basel, Switzerland},
article_number = {59},
doi = {http://dx.doi.org/10.1159/000353915},
keywords = {Breast cancer; Colon cancer; Cytotoxicity; Disulfiram; Reactive Oxygen Species; Tumor microenvironment},
language = {eng},
issn = {0009-3157},
journal = {CHEMOTHERAPY},
title = {Acidic pH of tumor microenvironment enhances cytotoxicity of disulfiram/Cu2+ complex to breast and colon cancer cells},
volume = {2013},
year = {2013}
}
TY - JOUR
ID - 1122524
AU - Navrátilová, Jarmila - Hankeová, Tereza - Beneš, Petr - Šmarda, Jan
PY - 2013
TI - Acidic pH of tumor microenvironment enhances cytotoxicity of disulfiram/Cu2+ complex to breast and colon cancer cells
JF - CHEMOTHERAPY
VL - 2013
IS - 59
SP - 112-120
EP - 112-120
PB - S. KARGER AG, Basel
SN - 00093157
KW - Breast cancer
KW - Colon cancer
KW - Cytotoxicity
KW - Disulfiram
KW - Reactive Oxygen Species
KW - Tumor microenvironment
N2 - A resistance of cancer cells to chemotherapeutic agents is a major cause of treatment failure in patients with cancer. The drug-resistance of tumor cells can be significantly modified by specific features of tumor microenvironment, such as oxygen depletion (hypoxia), glucose/energy deprivation and acidosis. The effects of acidic tumor-like microenvironment on cytotoxicity of antabuse (disulfiram)/Cu2+ complexes to MCF-7 breast carcinoma and HT-29 colon carcinoma cells were studied. We show that acidic pH significantly potentiates toxicity of disulfiram/Cu2+ complex to breast and colon cancer cells. This phenomenon is associated with changes in cell metabolism, altered Akt kinase and NFkappaB activities and increased reactive oxygen species production. Conclusion: Specific pH of tumor microenvironment enhances cytotoxicity of disulfiram/Cu2+ to breast and colon cancer cells.
ER -
NAVRÁTILOVÁ, Jarmila, Tereza HANKEOVÁ, Petr BENEŠ and Jan ŠMARDA. Acidic pH of tumor microenvironment enhances cytotoxicity of disulfiram/Cu2+ complex to breast and colon cancer cells. \textit{CHEMOTHERAPY}. Basel, Switzerland: S. KARGER AG, Basel, 2013, vol.~2013, No~59, p.~112-120. ISSN~0009-3157. Available from: https://dx.doi.org/10.1159/000353915.
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