RÁČIL, Zdeněk, Filip RÁZGA, Hana KLAMOVA, Jaroslava VOGLOVÁ, Petra BELOHLAVKOVA, Ludmila MALÁSKOVÁ, David POTĚŠIL, Jan MUŽÍK, Daniela ŽÁČKOVÁ, Katerina Machova POLAKOVA, Zbyněk ZDRÁHAL, Jana MALAKOVA, Jiri SUTTNAR, Jan DYR and Jiří MAYER. No clinical evidence for performing trough plasma and intracellular imatinib concentrations monitoring in patients with chronic myelogenous leukaemia. Hematological Oncology, Hoboken: WILEY-BLACKWELL, 2014, vol. 32, No 2, p. 87-93. ISSN 0278-0232. doi:10.1002/hon.2091.
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Basic information
Original name No clinical evidence for performing trough plasma and intracellular imatinib concentrations monitoring in patients with chronic myelogenous leukaemia
Authors RÁČIL, Zdeněk (203 Czechia, guarantor, belonging to the institution), Filip RÁZGA (703 Slovakia), Hana KLAMOVA (203 Czechia), Jaroslava VOGLOVÁ (203 Czechia), Petra BELOHLAVKOVA (203 Czechia), Ludmila MALÁSKOVÁ (203 Czechia), David POTĚŠIL (203 Czechia, belonging to the institution), Jan MUŽÍK (203 Czechia, belonging to the institution), Daniela ŽÁČKOVÁ (203 Czechia, belonging to the institution), Katerina Machova POLAKOVA (203 Czechia), Zbyněk ZDRÁHAL (203 Czechia, belonging to the institution), Jana MALAKOVA (203 Czechia), Jiri SUTTNAR (203 Czechia), Jan DYR (203 Czechia) and Jiří MAYER (203 Czechia, belonging to the institution).
Edition Hematological Oncology, Hoboken, WILEY-BLACKWELL, 2014, 0278-0232.
Other information
Original language English
Type of outcome article in a journal
Field of Study 30204 Oncology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW Full Text
Impact factor Impact factor: 3.084
RIV identification code RIV/00216224:14740/14:00074752
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1002/hon.2091
UT WoS 000340570100005
Keywords in English CML; imatinib; plasma concentration; cell-asscociated concentration
Tags EL OK, kontrola MP, ok, podil, rivok, SCOPUS
Tags International impact, Reviewed
Changed by Changed by: Mgr. Marie Šípková, DiS., učo 437722. Changed: 17. 12. 2019 10:25.
Abstract
This multicentre study focused on monitoring imatinib mesylate(IMA)trough plasma(Ctrough) and intracellular (IMA Cintrac) concentrations in 228 chronic myelogenous leukaemia patients. We found a correlation between IMA Ctrough and alpha 1-acid glycoprotein plasma concentrations. All other analysed parameters revealed only weak (gender, dose of IMA per kg) or not significant (age, albumin, creatinine plasma concentration or bodymass index) impact onmeasured IMA Ctrough. The IMA Ctrough decreased during the first 6months and significantly increased later during treatment. The IMA Ctrough at the first month of therapy did not differ between patients with and without an optimal response at the 12th (p = 0.724) and 18th month (p = 0.135) of therapy. The IMA Cintrac during the first month were not different between patients with and without an optimal response at the 6th (p=0.273) and the 12th month (p = 0.193) of therapy. Our data obtained from real life clinical practice did not find a benefit of routine and regular IMA Ctrough nor IMA Cintrac therapeutic drug monitoring in CML patients or for subsequent adjustments of the IMA dose based on these results. Moreover, actual alpha 1-acid glycoprotein plasma concentration should be used for proper interpretation of IMA Ctrough results.
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CZ.1.05/1.1.00/02.0068, internal MU codeName: CEITEC - středoevropský technologický institut (Acronym: CEITEC)
Investor: Ministry of Education, Youth and Sports of the CR, Operational Programme Research and Development for Innovation, 1.1 European Centres of Excellence
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EL_1122749_No_clinical_evidence.pdf  Prášilová, M. 17. 3. 2015

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