Urine microRNAs as potential noninvasive biomarkers in urologic
cancers?

J 2014

Urine microRNAs as potential noninvasive biomarkers in urologic cancers?

MLČOCHOVÁ, Hana, Renata HÉŽOVÁ, Michal STANÍK and Ondřej SLABÝ

Basic information

Original name

Urine microRNAs as potential noninvasive biomarkers in urologic cancers?

Authors

MLČOCHOVÁ, Hana (203 Czech Republic, belonging to the institution), Renata HÉŽOVÁ (203 Czech Republic, belonging to the institution), Michal STANÍK (703 Slovakia) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution)

Edition

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, New York, ELSEVIER SCIENCE INC, 2014, 1078-1439

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.768

RIV identification code

RIV/00216224:14740/14:00074753

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1016/j.urolonc.2013.04.011

UT WoS

000347243300069

Keywords in English

MicroRNA; Diagnosis; Biomarker; Urologic cancer; Urothelial cancer; Bladder cancer; Prostate cancer; Renal cell carcinoma

Abstract

V originále

Micro-ribonucleic acids (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression. The ability of miRNAs to inhibit translation of oncogenes and tumor suppressors implies that they may be involved in carcinogenesis. Our review focuses on the potential of urinary miRNAs to serve as biomarkers of urologic cancers. We discuss in detail the recent knowledge about the origin of urinary miRNAs, their stability, quality control, and their utility as a potential new class of biomarkers in urologic cancer. Finally, we summarize the studies focusing on detection and characterization of urinary miRNAs as potential biomarkers in bladder, prostate, and kidney cancers.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

NT13547, research and development project

Name: Studium mikroRNA a genů asociovaných s procesem epiteliálně-mezenchymální tranzice jako potenciálních markerů pro predikci rizika a časný záchyt metastazování u pacientů s renálním karcinomem

Citovat

MLČOCHOVÁ, Hana, Renata HÉŽOVÁ, Michal STANÍK and Ondřej SLABÝ. Urine microRNAs as potential noninvasive biomarkers in urologic cancers? UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS. New York: ELSEVIER SCIENCE INC, 2014, vol. 32, No 1, p. "41.e1"-"41.e9", 9 pp. ISSN 1078-1439. Available from: https://dx.doi.org/10.1016/j.urolonc.2013.04.011.

@article{1122858,
   author = {Mlčochová, Hana and Héžová, Renata and Staník, Michal and Slabý, Ondřej},
   article_location = {New York},
   article_number = {1},
   doi = {http://dx.doi.org/10.1016/j.urolonc.2013.04.011},
   keywords = {MicroRNA; Diagnosis; Biomarker; Urologic cancer; Urothelial cancer; Bladder cancer; Prostate cancer; Renal cell carcinoma},
   language = {eng},
   issn = {1078-1439},
   journal = {UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS},
   title = {Urine microRNAs as potential noninvasive biomarkers in urologic cancers?},
   url = {http://www.sciencedirect.com/science/article/pii/S107814391300197X},
   volume = {32},
   year = {2014}
}

TY  - JOUR
ID  - 1122858
AU  - Mlčochová, Hana - Héžová, Renata - Staník, Michal - Slabý, Ondřej
PY  - 2014
TI  - Urine microRNAs as potential noninvasive biomarkers in urologic cancers?
JF  - UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
VL  - 32
IS  - 1
SP  - "41.e1"-"41.e9"
EP  - "41.e1"-"41.e9"
PB  - ELSEVIER SCIENCE INC
SN  - 10781439
KW  - MicroRNA
KW  - Diagnosis
KW  - Biomarker
KW  - Urologic cancer
KW  - Urothelial cancer
KW  - Bladder cancer
KW  - Prostate cancer
KW  - Renal cell carcinoma
UR  - http://www.sciencedirect.com/science/article/pii/S107814391300197X
L2  - http://www.sciencedirect.com/science/article/pii/S107814391300197X
N2  - Micro-ribonucleic acids (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression. The ability of miRNAs to inhibit translation of oncogenes and tumor suppressors implies that they may be involved in carcinogenesis. Our review focuses on the potential of urinary miRNAs to serve as biomarkers of urologic cancers. We discuss in detail the recent knowledge about the origin of urinary miRNAs, their stability, quality control, and their utility as a potential new class of biomarkers in urologic cancer. Finally, we summarize the studies focusing on detection and characterization of urinary miRNAs as potential biomarkers in bladder, prostate, and kidney cancers.
ER  -

MLČOCHOVÁ, Hana, Renata HÉŽOVÁ, Michal STANÍK and Ondřej SLABÝ. Urine microRNAs as potential noninvasive biomarkers in urologic cancers? \textit{UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS}. New York: ELSEVIER SCIENCE INC, 2014, vol.~32, No~1, p.~''41.e1''-''41.e9'', 9 pp. ISSN~1078-1439. Available from: https://dx.doi.org/10.1016/j.urolonc.2013.04.011.

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