Arrhythmogenesis in Brugada syndrome: Impact and constrains of
current concepts

J 2013

Arrhythmogenesis in Brugada syndrome: Impact and constrains of current concepts

BÉBAROVÁ, Markéta

Basic information

Original name

Arrhythmogenesis in Brugada syndrome: Impact and constrains of current concepts

Authors

BÉBAROVÁ, Markéta (203 Czech Republic, guarantor, belonging to the institution)

Edition

International Journal of Cardiology, Amsterdam, Elsevier, 2013, 0167-5273

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 6.175

RIV identification code

RIV/00216224:14110/13:00069377

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.ijcard.2012.12.019

UT WoS

000323569600029

Keywords in English

Arrhythmogenesis; Atrial fibrillation; Brugada syndrome; Discontinuous conduction; Dysfunction; Mutation

Abstract

V originále

Brugada syndrome (BrS), an inherited arrhythmogenic disease first described in 1992, is characterized by ST segment elevations on the electrocardiogram in the right precordium and by a high occurrence of arrhythmias including the life-threatening ventricular tachycardia/fibrillation. Knowledge of the underlying mechanisms of formation of arrhythmogenic substrate in BrS is essential, namely for the risk stratification of BrS patients and their therapy which is still restrained almost exclusively to the implantation of cardioverter/defibrillator. In spite of many crucial findings in this field published within recent years, the final consistent view has not been established so far. Hence, BrS described 20 years ago remains an actual topic of both clinical and experimental studies. This review presents an overview of the current knowledge related to the pathogenesis of BrS arrhythmogenic substrate, namely of the genetic basis of BrS, functional consequences of mutations related to BrS, and arrhythmogenic mechanisms in BrS.

Links

MSM0021622402, plan (intention)

Name: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases

Files attached

Arrhythmogenesis_in_Brugada.pdf

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Citovat

BÉBAROVÁ, Markéta. Arrhythmogenesis in Brugada syndrome: Impact and constrains of current concepts. International Journal of Cardiology. Amsterdam: Elsevier, 2013, vol. 167, No 5, p. 1760-1771. ISSN 0167-5273. Available from: https://dx.doi.org/10.1016/j.ijcard.2012.12.019.

@article{1122863,
   author = {Bébarová, Markéta},
   article_location = {Amsterdam},
   article_number = {5},
   doi = {http://dx.doi.org/10.1016/j.ijcard.2012.12.019},
   keywords = {Arrhythmogenesis; Atrial fibrillation; Brugada syndrome; Discontinuous conduction; Dysfunction; Mutation},
   language = {eng},
   issn = {0167-5273},
   journal = {International Journal of Cardiology},
   title = {Arrhythmogenesis in Brugada syndrome: Impact and constrains of current concepts},
   volume = {167},
   year = {2013}
}

TY  - JOUR
ID  - 1122863
AU  - Bébarová, Markéta
PY  - 2013
TI  - Arrhythmogenesis in Brugada syndrome: Impact and constrains of current concepts
JF  - International Journal of Cardiology
VL  - 167
IS  - 5
SP  - 1760-1771
EP  - 1760-1771
PB  - Elsevier
SN  - 01675273
KW  - Arrhythmogenesis
KW  - Atrial fibrillation
KW  - Brugada syndrome
KW  - Discontinuous conduction
KW  - Dysfunction
KW  - Mutation
N2  - Brugada syndrome (BrS), an inherited arrhythmogenic disease first described in 1992, is characterized by ST segment elevations on the electrocardiogram in the right precordium and by a high occurrence of arrhythmias including the life-threatening ventricular tachycardia/fibrillation. Knowledge of the underlying mechanisms of formation of arrhythmogenic substrate in BrS is essential, namely for the risk stratification of BrS patients and their therapy which is still restrained almost exclusively to the implantation of cardioverter/defibrillator. In spite of many crucial findings in this field published within recent years, the final consistent view has not been established so far. Hence, BrS described 20 years ago remains an actual topic of both clinical and experimental studies. This review presents an overview of the current knowledge related to the pathogenesis of BrS arrhythmogenic substrate, namely of the genetic basis of BrS, functional consequences of mutations related to BrS, and arrhythmogenic mechanisms in BrS.
ER  -

BÉBAROVÁ, Markéta. Arrhythmogenesis in Brugada syndrome: Impact and constrains of current concepts. \textit{International Journal of Cardiology}. Amsterdam: Elsevier, 2013, vol.~167, No~5, p.~1760-1771. ISSN~0167-5273. Available from: https://dx.doi.org/10.1016/j.ijcard.2012.12.019.

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