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@article{1122872, author = {Vašků, Anna and Bienertová Vašků, Julie and Izakovičová Hollá, Lydie and Pávková Goldbergová, Monika and Kozáčiková, Zuzana and Šplíchal, Zbyněk and Vašků, Vladimír}, article_location = {USA}, article_number = {8}, doi = {http://dx.doi.org/10.1111/ijd.12213}, keywords = {MAJOR HISTOCOMPATIBILITY COMPLEX; CLASS-II REGION; HAPLOTYPE RECONSTRUCTION; MEIOTIC RECOMBINATION; POPULATION; SUSCEPTIBILITY; VULGARIS; ASSOCIATION; LOCUS}, language = {eng}, issn = {0011-9059}, journal = {International Journal of Dermatology}, title = {Polymorphisms in HLA-related genes and psoriasis heredity in patients with psoriasis}, volume = {52}, year = {2013} }
TY - JOUR ID - 1122872 AU - Vašků, Anna - Bienertová Vašků, Julie - Izakovičová Hollá, Lydie - Pávková Goldbergová, Monika - Kozáčiková, Zuzana - Šplíchal, Zbyněk - Vašků, Vladimír PY - 2013 TI - Polymorphisms in HLA-related genes and psoriasis heredity in patients with psoriasis JF - International Journal of Dermatology VL - 52 IS - 8 SP - 960-965 EP - 960-965 PB - Wiley-Blackwell SN - 00119059 KW - MAJOR HISTOCOMPATIBILITY COMPLEX KW - CLASS-II REGION KW - HAPLOTYPE RECONSTRUCTION KW - MEIOTIC RECOMBINATION KW - POPULATION KW - SUSCEPTIBILITY KW - VULGARIS KW - ASSOCIATION KW - LOCUS N2 - Background The aim of this study was to investigate possible associations of the five DNA polymorphic genotypes in the HLA region (transporter associated with antigen processing [TAP1; TAP1333 a/b, TAP1637 c/d], the HLA-DRB1*1501-rs3135388, tumor necrosis factor [TNF] [-238 G/A] and NcoI TNF) with characteristics of family history in patients with psoriasis vulgaris. Materials and methods A total of 201 Czech patients with psoriasis were enrolled in the study. The patients were genotyped for the five common polymorphisms in TAP1, TNF, and TNF genes (6p21.3) using the polymerase chain reaction-restriction fragment length polymorphism-based methodology. Results We observed significantly higher prevalence of Ile333Ile TAP1 allele in patients whose first-degree relatives had a positive family history of psoriasis (P-a=0.04). No differences related to family history of psoriasis were observed in HLA-DRB1*1501 polymorphism. As for the TNF (-238 G/A) polymorphism, a significant increase of the GG genotype was observed in patients, especially men with second- and third-degree relatives with psoriasis (P-g=0.008). Similarly, the B2B2 genotype of NcoI TNF polymorphism was more frequent in psoriatic patients, especially women, whose second- and third-degree relatives had psoriasis (P-g=0.004). Finally, the haplotype analysis of all five polymorphisms revealed that the frequency of haplotype bcCB1A was different between not only men and women with psoriasis (P=0.007) but also between men and women without a family history of psoriasis (P=0.007). Conclusions Haplotype association of HLA gene polymorphisms with genealogy aspects of psoriasis facilitates a better understanding of etiopathogenetic aspects of the diseases. ER -
VAŠKŮ, Anna, Julie BIENERTOVÁ VAŠKŮ, Lydie IZAKOVIČOVÁ HOLLÁ, Monika PÁVKOVÁ GOLDBERGOVÁ, Zuzana KOZÁČIKOVÁ, Zbyněk ŠPLÍCHAL and Vladimír VAŠKŮ. Polymorphisms in HLA-related genes and psoriasis heredity in patients with psoriasis. \textit{International Journal of Dermatology}. USA: Wiley-Blackwell, 2013, vol.~52, No~8, p.~960-965. ISSN~0011-9059. Available from: https://dx.doi.org/10.1111/ijd.12213.
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