VAŠKŮ, Anna, Julie BIENERTOVÁ VAŠKŮ, Lydie IZAKOVIČOVÁ HOLLÁ, Monika PÁVKOVÁ GOLDBERGOVÁ, Zuzana KOZÁČIKOVÁ, Zbyněk ŠPLÍCHAL and Vladimír VAŠKŮ. Polymorphisms in HLA-related genes and psoriasis heredity in patients with psoriasis. International Journal of Dermatology. USA: Wiley-Blackwell, 2013, vol. 52, No 8, p. 960-965. ISSN 0011-9059. Available from: https://dx.doi.org/10.1111/ijd.12213.
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Basic information
Original name Polymorphisms in HLA-related genes and psoriasis heredity in patients with psoriasis
Authors VAŠKŮ, Anna (203 Czech Republic, belonging to the institution), Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, guarantor, belonging to the institution), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, belonging to the institution), Monika PÁVKOVÁ GOLDBERGOVÁ (203 Czech Republic, belonging to the institution), Zuzana KOZÁČIKOVÁ (703 Slovakia, belonging to the institution), Zbyněk ŠPLÍCHAL (203 Czech Republic, belonging to the institution) and Vladimír VAŠKŮ (203 Czech Republic, belonging to the institution).
Edition International Journal of Dermatology, USA, Wiley-Blackwell, 2013, 0011-9059.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30216 Dermatology and venereal diseases
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.227
RIV identification code RIV/00216224:14110/13:00069381
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1111/ijd.12213
UT WoS 000322015000009
Keywords in English MAJOR HISTOCOMPATIBILITY COMPLEX; CLASS-II REGION; HAPLOTYPE RECONSTRUCTION; MEIOTIC RECOMBINATION; POPULATION; SUSCEPTIBILITY; VULGARIS; ASSOCIATION; LOCUS
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 19/3/2014 10:08.
Abstract
Background The aim of this study was to investigate possible associations of the five DNA polymorphic genotypes in the HLA region (transporter associated with antigen processing [TAP1; TAP1333 a/b, TAP1637 c/d], the HLA-DRB1*1501-rs3135388, tumor necrosis factor [TNF] [-238 G/A] and NcoI TNF) with characteristics of family history in patients with psoriasis vulgaris. Materials and methods A total of 201 Czech patients with psoriasis were enrolled in the study. The patients were genotyped for the five common polymorphisms in TAP1, TNF, and TNF genes (6p21.3) using the polymerase chain reaction-restriction fragment length polymorphism-based methodology. Results We observed significantly higher prevalence of Ile333Ile TAP1 allele in patients whose first-degree relatives had a positive family history of psoriasis (P-a=0.04). No differences related to family history of psoriasis were observed in HLA-DRB1*1501 polymorphism. As for the TNF (-238 G/A) polymorphism, a significant increase of the GG genotype was observed in patients, especially men with second- and third-degree relatives with psoriasis (P-g=0.008). Similarly, the B2B2 genotype of NcoI TNF polymorphism was more frequent in psoriatic patients, especially women, whose second- and third-degree relatives had psoriasis (P-g=0.004). Finally, the haplotype analysis of all five polymorphisms revealed that the frequency of haplotype bcCB1A was different between not only men and women with psoriasis (P=0.007) but also between men and women without a family history of psoriasis (P=0.007). Conclusions Haplotype association of HLA gene polymorphisms with genealogy aspects of psoriasis facilitates a better understanding of etiopathogenetic aspects of the diseases.
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