BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Filip ZLÁMAL, Zbyněk ŠPLÍCHAL, Josef TOMANDL, Marie TOMANDLOVÁ, Zuzana HODICKÁ, Pavel VENTRUBA and Anna VAŠKŮ. Brain-derived neurotrophic factor and ciliary neurotrophic factor in maternal plasma and umbilical cord blood from pre-eclamptic and physiological pregnancies. JOURNAL OF OBSTETRICS AND GYNAECOLOGY. NEW YORK: INFORMA HEALTHCARE, 2013, vol. 33, No 4, p. 359-363. ISSN 0144-3615. doi:10.3109/01443615.2013.776026.
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Basic information
Original name Brain-derived neurotrophic factor and ciliary neurotrophic factor in maternal plasma and umbilical cord blood from pre-eclamptic and physiological pregnancies
Authors BIENERTOVÁ VAŠKŮ, Julie (203 Czech Republic, guarantor, belonging to the institution), Petr BIENERT (203 Czech Republic), Filip ZLÁMAL (203 Czech Republic, belonging to the institution), Zbyněk ŠPLÍCHAL (203 Czech Republic, belonging to the institution), Josef TOMANDL (203 Czech Republic, belonging to the institution), Marie TOMANDLOVÁ (203 Czech Republic, belonging to the institution), Zuzana HODICKÁ (203 Czech Republic), Pavel VENTRUBA (203 Czech Republic) and Anna VAŠKŮ (203 Czech Republic, belonging to the institution).
Edition JOURNAL OF OBSTETRICS AND GYNAECOLOGY, NEW YORK, INFORMA HEALTHCARE, 2013, 0144-3615.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30214 Obstetrics and gynaecology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.604
RIV identification code RIV/00216224:14110/13:00069383
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.3109/01443615.2013.776026
UT WoS 000318656400008
Keywords in English Brain-derived neurotrophic factor; ciliary neurotrophic factor; pre-eclampsia
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 23/9/2013 11:20.
Abstract
The aim of the study was to investigate the circulating levels of ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) in maternal serum and umbilical cord blood from respective pregnancies in pre-eclampsia (PE) cases and a control cohort. A total of 12 pre-eclampsia cases and 34 healthy controls were enrolled and the maternal peripheral blood - umbilical cord blood duos, were examined for BDNF and CNTF levels. BNDF levels were significantly higher in umbilical cord blood from pre-eclamptic pregnancies; there was also significant difference between maternal plasma and umbilical cord blood levels of BDNF (p < 0.001) in the controls. The CNTF levels in umbilical cord blood (CNTF-UCB) were significantly higher in PE cases than in the controls (p = 0.03). Significant differences were observed in expression of BDNF and CNTF proteins in maternal peripheral blood and umbilical cord blood between pre-eclampsia cases and healthy controls.
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