| HRADILOVÁ SVÍŽENSKÁ, Ivana, Václav BRÁZDA, Ilona KLUSÁKOVÁ and Petr DUBOVÝ. Bilateral Changes of Cannabinoid Receptor Type 2 Protein and mRNA in the Dorsal Root Ganglia of a Rat Neuropathic Pain Model. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY. LONDON: SAGE PUBLICATIONS LTD, 2013, vol. 61, No 7, p. 529-547. ISSN 0022-1554. Available from: https://dx.doi.org/10.1369/0022155413491269. |
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@article{1124208,
author = {Hradilová Svíženská, Ivana and Brázda, Václav and Klusáková, Ilona and Dubový, Petr},
article_location = {LONDON},
article_number = {7},
doi = {http://dx.doi.org/10.1369/0022155413491269},
keywords = {unilateral nerve injury; remote neuroinflammation; satellite glial cells},
language = {eng},
issn = {0022-1554},
journal = {JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY},
title = {Bilateral Changes of Cannabinoid Receptor Type 2 Protein and mRNA in the Dorsal Root Ganglia of a Rat Neuropathic Pain Model},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23657829},
volume = {61},
year = {2013}
}
TY - JOUR
ID - 1124208
AU - Hradilová Svíženská, Ivana - Brázda, Václav - Klusáková, Ilona - Dubový, Petr
PY - 2013
TI - Bilateral Changes of Cannabinoid Receptor Type 2 Protein and mRNA in the Dorsal Root Ganglia of a Rat Neuropathic Pain Model
JF - JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
VL - 61
IS - 7
SP - 529-547
EP - 529-547
PB - SAGE PUBLICATIONS LTD
SN - 00221554
KW - unilateral nerve injury
KW - remote neuroinflammation
KW - satellite glial cells
UR - http://www.ncbi.nlm.nih.gov/pubmed/23657829
L2 - http://www.ncbi.nlm.nih.gov/pubmed/23657829
N2 - Cannabinoid receptor type 2 (CB2R) plays a critical role in nociception. In contrast to cannabinoid receptor type 1 ligands, CB2R agonists do not produce undesirable central nervous system effects and thus promise to treat neuropathic pain that is often resistant to medical therapy. In the study presented here, we evaluated the bilateral distribution of the CB2R protein and messenger RNA (mRNA) in rat dorsal root ganglia (DRG) after unilateral peripheral nerve injury using immunohistochemistry, western blot, and in situ hybridization analysis. Unilateral chronic constriction injury (CCI) of the sciatic nerve induced neuropathic pain behavior and bilateral elevation of both CB2R protein and mRNA in lumbar L4-L5 as well as cervical C7-C8 DRG when compared with naive animals. CB2R protein and mRNA were increased not only in DRG neurons but also in satellite glial cells. The fact that changes appear bilaterally and (albeit at a lower level) even in the remote cervical DRG can be related to propagation of neuroinflammation alongside the neuraxis and to the neuroprotective effects of CB2R.
ER -
HRADILOVÁ SVÍŽENSKÁ, Ivana, Václav BRÁZDA, Ilona KLUSÁKOVÁ and Petr DUBOVÝ. Bilateral Changes of Cannabinoid Receptor Type 2 Protein and mRNA in the Dorsal Root Ganglia of a Rat Neuropathic Pain Model. \textit{JOURNAL OF HISTOCHEMISTRY \&{} CYTOCHEMISTRY}. LONDON: SAGE PUBLICATIONS LTD, 2013, vol.~61, No~7, p.~529-547. ISSN~0022-1554. Available from: https://dx.doi.org/10.1369/0022155413491269.
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