Detailed Information on Publication Record
2013
Current survival measures reliably reflect modern sequential treatment in CML: Correlation with prognostic stratifications
PAVLÍK, Tomáš, Eva JANOUŠOVÁ, Jiří MAYER, Karel INDRÁK, Marie JAROSOVA et. al.Basic information
Original name
Current survival measures reliably reflect modern sequential treatment in CML: Correlation with prognostic stratifications
Authors
PAVLÍK, Tomáš (203 Czech Republic, guarantor, belonging to the institution), Eva JANOUŠOVÁ (203 Czech Republic, belonging to the institution), Jiří MAYER (203 Czech Republic, belonging to the institution), Karel INDRÁK (203 Czech Republic), Marie JAROSOVA (203 Czech Republic), Hana KLAMOVA (203 Czech Republic), Daniela ŽÁČKOVÁ (203 Czech Republic, belonging to the institution), Jaroslava VOGLOVÁ (203 Czech Republic), Edgar FABER (203 Czech Republic), Michal KARAS (203 Czech Republic), Katerina POLAKOVA MACHOVA (203 Czech Republic), Zdeněk RÁČIL (203 Czech Republic, belonging to the institution), Eva DEMEČKOVÁ (703 Slovakia), Ludmila DEMITROVIČOVÁ (703 Slovakia), Elena TOTHOVÁ (703 Slovakia), Juraj CHUDEJ (703 Slovakia), Imrich MARKULJAK (703 Slovakia), Eduard CMUNT (203 Czech Republic), Tomas KOZAK (203 Czech Republic), Jan MUŽÍK (203 Czech Republic, belonging to the institution) and Ladislav DUŠEK (203 Czech Republic, belonging to the institution)
Edition
American Journal of Hematology, Hoboken, Wiley-Blackwell, 2013, 0361-8609
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30200 3.2 Clinical medicine
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 3.477
RIV identification code
RIV/00216224:14110/13:00069543
Organization unit
Faculty of Medicine
UT WoS
000323313500013
Keywords in English
CHRONIC MYELOID-LEUKEMIA; TYROSINE KINASE INHIBITORS; COMPLETE CYTOGENETIC RESPONSE; CHRONIC-PHASE; BCR-ABL; MOLECULAR RESPONSE; IMATINIB MESYLATE; INTERFERON-ALPHA; THERAPY; FAILURE
Tags
International impact, Reviewed
Změněno: 17/2/2014 10:53, Ing. Mgr. Věra Pospíšilíková
Abstract
V originále
Using the data of 723 chronic myeloid leukemia (CML) patients in the chronic phase, we analyzed the prognostic value of the Sokal, Euro, and EUTOS scores as well as the level of BCR-ABL1 and the achievement of complete cytogenetic response (CCgR) at 3 months of imatinib therapy in relation to the so-called current survival measures: the current cumulative incidence (CCI) reflecting the probability of being alive and in CCgR after starting imatinib therapy; the current leukemia-free survival (CLFS) reflecting the probability of being alive and in CCgR after achieving the first CCgR; and the overall survival. The greatest difference between the CCI curves at 5 years after initiating imatinib therapy was observed for the BCR-ABL1 transcripts at 3 months. The 5-year CCI was 94.3% in patients with BCR-ABL1 transcripts10% and 57.1% in patients with BCR-ABL1 transcripts>10% (P=0.005). Therefore, the examination of BCR-ABL1 transcripts at 3 months may help in early identification of patients who are likely to perform poorly with imatinib. On the other hand, CLFS was not significantly affected by the considered stratifications. In conclusion, our results indicate that once the CCgR is achieved, the prognosis is good irrespective of the starting prognostic risks.