HART, Radek, Adel Mohammad Mahmoud SAFI, Martin KOMZÁK, Pavel JAJTNER, Milos PUSKEILER and Petra HARTOVA. Platelet-rich plasma in patients with tibiofemoral cartilage degeneration. ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY. NEW YORK: SPRINGER, 2013, vol. 133, No 9, p. 1295-1301. ISSN 0936-8051. Available from: https://dx.doi.org/10.1007/s00402-013-1782-x.
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Basic information
Original name Platelet-rich plasma in patients with tibiofemoral cartilage degeneration
Authors HART, Radek (203 Czech Republic, guarantor, belonging to the institution), Adel Mohammad Mahmoud SAFI (400 Jordan, belonging to the institution), Martin KOMZÁK (203 Czech Republic, belonging to the institution), Pavel JAJTNER (203 Czech Republic), Milos PUSKEILER (203 Czech Republic) and Petra HARTOVA (203 Czech Republic).
Edition ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY, NEW YORK, SPRINGER, 2013, 0936-8051.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30211 Orthopaedics
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.310
RIV identification code RIV/00216224:14110/13:00069554
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1007/s00402-013-1782-x
UT WoS 000323638100015
Keywords in English Knee; Chondromalatia; Platelet-rich plasma
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 1/10/2013 15:28.
Abstract
Recently an articular cartilage repair has been given much attention in the orthopaedic field. Cartilage regeneration capacity is very limited. Optimal approach seems to be a delivery of natural growth factors. Autologous platelet-rich plasma (PRP) contains proliferative and chemoattractant growth factors. The objective of the present study was to determine if PRP can increase tibiofemoral cartilage regeneration and improve knee function. Fifty consecutive and strictly selected patients, affected by Grade II or III chondromalatia, underwent 1 year treatment (9 injections) with autologous PRP in a liquid form with 2.0 to 2.5-fold platelets concentration. Outcome measures included the Lysholm, Tegner, IKDC, and Cincinnati scores. Magnetic resonance imaging was used to evaluate cartilage thickness and degree of degeneration. The study demonstrated significant improvement in Lysholm (p < 0.05), Tegner (p < 0.05), IKDC (p < 0.05), and Cincinnati (p < 0.05) scores. Results improved at 12-month follow-up. Cartilage assessment revealed no significant cartilage regeneration (p < 0.05). There were no adverse events reported. PRP significantly reduced pain and improved quality of live in patients with low degree of cartilage degeneration. Magnetic resonance imaging did not confirmed any significant cartilage condition improvement.
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