Detailed Information on Publication Record
2013
Characteristics of Staphylococcus aureus strains resistant to polyvalent bacteriophages used for phage therapy
DOŠKAŘ, Jiří, Markéta ŠTREITOVÁ, Petra FORMANOVÁ, Marian VARGA, Roman PANTŮČEK et. al.Basic information
Original name
Characteristics of Staphylococcus aureus strains resistant to polyvalent bacteriophages used for phage therapy
Authors
Edition
The 13th International Conference on Culture Collections (ICCC13), 2013
Other information
Language
English
Type of outcome
Konferenční abstrakt
Field of Study
Genetics and molecular biology
Country of publisher
China
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Organization unit
Faculty of Science
Keywords in English
bacteriophages; Staphylococcus aureus; phage therapy
Změněno: 1/8/2015 18:43, prof. RNDr. Roman Pantůček, Ph.D.
Abstract
V originále
The polyvalent staphylococcal bacteriophage phi812 and its host-range mutants, members of Myoviridae family, lyse most of Staphylococcus aureus strains and are, therefore, used in therapy of staphylococcal infections. However, some 5-10% of the strains are insensitive to these phages, which may reduce the effectiveness of phage-based therapy. In this work we analysed the possible defence mechanisms of the strains which can result in their insensitivity to phages. Therefore, we examined correlation between strain insensitivity and efficiency of phage adsorption on bacterial cells, presence of the SauI restriction-modification (RM) system and content of resident prophages. For the study, a set of genotypically well characterized S. aureus strains from distinct clonal complexes (CC) differing in their prophage content was used.
Links
| EE2.3.20.0183, research and development project |
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| TA01010405, research and development project |
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