Characterization of in vitro lytic activity of bacteriophage
preparation STAFAL against Staphylococcus aureus

a 2013

Characterization of in vitro lytic activity of bacteriophage preparation STAFAL against Staphylococcus aureus

PANTŮČEK, Roman, Milada DVOŘÁČKOVÁ, Martin BENEŠÍK, Jiří DOŠKAŘ, Ivana MAŠLAŇOVÁ et. al.

Basic information

Original name

Characterization of in vitro lytic activity of bacteriophage preparation STAFAL against Staphylococcus aureus

Authors

PANTŮČEK, Roman, Milada DVOŘÁČKOVÁ, Martin BENEŠÍK, Jiří DOŠKAŘ, Ivana MAŠLAŇOVÁ, Vladislava RŮŽIČKOVÁ, Filip RŮŽIČKA and Marek MOŠA

Edition

Molecular Genetics of Bacteria and Phages, 2013

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

Genetics and molecular biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Organization unit

Faculty of Science

Změněno: 11/10/2013 15:44, prof. RNDr. Roman Pantůček, Ph.D.

Abstract

V originále

Staphylococcus aureus is one of the most common gram-positive opportunistic pathogens in humans causing from minor skin to severe systemic infections. The newly acquired genes responsible for virulence and resistance to antibiotics are rapidly disseminated in the staphylococcal population and multiple-resistant S. aureus strains represent a significant medical problem. Bacteriophages with a broad host range are suitable for fighting these pathogenic bacteria as an alternative to antibiotic therapy. In this work we summarize the results of susceptibility testing of S. aureus strains to bacteriophage preparation STAFAL in a routine clinical microbiology laboratory. STAFAL is an antistaphylococcal phage lysate for topical application produced under GMP by IMUNA s.r.o. in the Czech Republic, containing highly effective virulent phage particles with a strong and rapid lytic and polyvalent effect. A set of 400 S. aureus strains collected from 10 health-care facilities in Brno (Czech Republic) during 2011 -2013 , including isolates from outpatients' and inpatients' departments was tested in this work.

Links

NT12395, research and development project

Name: Molekulární průkaz a analýza invazivních kmenů small colony variants (SCV) a rezistentních kmenů S. aureus od pacientů s cystickou fibrózou

TA01010405, research and development project

Name: Výzkum stafylokokových bakteriofágových mutant s širokým spektrem hostitelů (Acronym: TAČR/IMUNA-1)

Investor: Technology Agency of the Czech Republic

Citovat

PANTŮČEK, Roman, Milada DVOŘÁČKOVÁ, Martin BENEŠÍK, Jiří DOŠKAŘ, Ivana MAŠLAŇOVÁ, Vladislava RŮŽIČKOVÁ, Filip RŮŽIČKA and Marek MOŠA. Characterization of in vitro lytic activity of bacteriophage preparation STAFAL against Staphylococcus aureus. In Molecular Genetics of Bacteria and Phages. 2013.

@proceedings{1125489,
   author = {Pantůček, Roman and Dvořáčková, Milada and Benešík, Martin and Doškař, Jiří and Mašlaňová, Ivana and Růžičková, Vladislava and Růžička, Filip and Moša, Marek},
   booktitle = {Molecular Genetics of Bacteria and Phages},
   language = {eng},
   title = {Characterization of in vitro lytic activity of bacteriophage preparation STAFAL against Staphylococcus aureus},
   url = {http://www.union.wisc.edu/phages/},
   year = {2013}
}

TY  - CONF
ID  - 1125489
AU  - Pantůček, Roman - Dvořáčková, Milada - Benešík, Martin - Doškař, Jiří - Mašlaňová, Ivana - Růžičková, Vladislava - Růžička, Filip - Moša, Marek
PY  - 2013
TI  - Characterization of in vitro lytic activity of bacteriophage preparation STAFAL against Staphylococcus aureus
UR  - http://www.union.wisc.edu/phages/
N2  - Staphylococcus aureus is one of the most common gram-positive opportunistic pathogens in humans causing from minor skin to severe systemic infections. The newly acquired genes responsible for virulence and resistance to antibiotics are rapidly disseminated in the staphylococcal population and multiple-resistant S. aureus strains represent a significant medical problem. Bacteriophages with a broad host range are suitable for fighting these pathogenic bacteria as an alternative to antibiotic therapy. In this work we summarize the results of susceptibility testing of S. aureus strains to bacteriophage preparation STAFAL in a routine clinical microbiology laboratory. STAFAL is an antistaphylococcal phage lysate for topical application produced under GMP by IMUNA s.r.o. in the Czech Republic, containing highly effective virulent phage particles with a strong and rapid lytic and polyvalent effect. A set of 400 S. aureus strains collected from 10 health-care facilities in Brno (Czech Republic) during 2011 -2013 , including isolates from outpatients' and inpatients' departments was tested in this work.
ER  -

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