PIRRACCHIO, Romain, Jiří PAŘENICA, Matthieu Resche RIGON, Sylvie CHEVRET, Jindřich ŠPINAR, Jiří JARKOVSKÝ, Faiez ZANNAD, Francois ALLA and Alexandre MEBAZAA. The Effectiveness of Inodilators in Reducing Short Term Mortality among Patient with Severe Cardiogenic Shock: A Propensity-Based Analysis. Plos One. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2013, vol. 8, No 8, p. e71659, 10 pp. ISSN 1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0071659. |
Other formats:
BibTeX
LaTeX
RIS
@article{1126259, author = {Pirracchio, Romain and Pařenica, Jiří and Rigon, Matthieu Resche and Chevret, Sylvie and Špinar, Jindřich and Jarkovský, Jiří and Zannad, Faiez and Alla, Francois and Mebazaa, Alexandre}, article_location = {SAN FRANCISCO}, article_number = {8}, doi = {http://dx.doi.org/10.1371/journal.pone.0071659}, keywords = {ACUTE HEART-FAILURE; MICROCIRCULATORY BLOOD-FLOW; VENTRICULAR-FUNCTION; CONTROLLED TRIAL; NOREPINEPHRINE; DOBUTAMINE; NITROGLYCERIN; EPINEPHRINE; GUIDELINES; MANAGEMENT}, language = {eng}, issn = {1932-6203}, journal = {Plos One}, title = {The Effectiveness of Inodilators in Reducing Short Term Mortality among Patient with Severe Cardiogenic Shock: A Propensity-Based Analysis}, volume = {8}, year = {2013} }
TY - JOUR ID - 1126259 AU - Pirracchio, Romain - Pařenica, Jiří - Rigon, Matthieu Resche - Chevret, Sylvie - Špinar, Jindřich - Jarkovský, Jiří - Zannad, Faiez - Alla, Francois - Mebazaa, Alexandre PY - 2013 TI - The Effectiveness of Inodilators in Reducing Short Term Mortality among Patient with Severe Cardiogenic Shock: A Propensity-Based Analysis JF - Plos One VL - 8 IS - 8 SP - e71659 EP - e71659 PB - PUBLIC LIBRARY SCIENCE SN - 19326203 KW - ACUTE HEART-FAILURE KW - MICROCIRCULATORY BLOOD-FLOW KW - VENTRICULAR-FUNCTION KW - CONTROLLED TRIAL KW - NOREPINEPHRINE KW - DOBUTAMINE KW - NITROGLYCERIN KW - EPINEPHRINE KW - GUIDELINES KW - MANAGEMENT N2 - Background:The best catecholamine regimen for cardiogenic shock has been poorly evaluated. When a vasopressor is required to treat patients with the most severe form of cardiogenic shock, whether inodilators should be added or whether inopressors can be used alone has not been established. The purpose of this study was to compare the impact of these two strategies on short-term mortality in patients with severe cardiogenic shocks.Methods and Results:Three observational cohorts of patients with decompensated heart failure were pooled to comprise a total of 1,272 patients with cardiogenic shocks. Of these 1,272 patients, 988 were considered to be severe because they required a vasopressor during the first 24 hours. We developed a propensity-score (PS) model to predict the individual probability of receiving one of the two regimens (inopressors alone or a combination) conditionally on baseline-measured covariates. The benefit of the treatment regimen on the mortality rate was estimated by fitting a weighted Cox regression model. A total of 643 patients (65.1%) died within the first 30 days (inopressors alone: 293 (72.0%); inopressors and inodilators: 350 (60.0%)). After PS weighting, we observed that the use of an inopressor plus an inodilator was associated with an improved short-term mortality (HR: 0.66 [0.55-0.80]) compared to inopressors alone.Conclusions:In the most severe forms of cardiogenic shock where a vasopressor is immediately required, adding an inodilator may improve short-term mortality. This result should be confirmed in a randomized, controlled trial. ER -
PIRRACCHIO, Romain, Jiří PAŘENICA, Matthieu Resche RIGON, Sylvie CHEVRET, Jindřich ŠPINAR, Jiří JARKOVSKÝ, Faiez ZANNAD, Francois ALLA and Alexandre MEBAZAA. The Effectiveness of Inodilators in Reducing Short Term Mortality among Patient with Severe Cardiogenic Shock: A Propensity-Based Analysis. \textit{Plos One}. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2013, vol.~8, No~8, p.~e71659, 10 pp. ISSN~1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0071659.
|