| DUBOVÝ, Petr, Radim JANČÁLEK and Tomáš KUBEK. Role of Inflammation and Cytokines in Peripheral Nerve Regeneration. International Review of Neurobiology. San Diego: Elsevier Inc., 2013, vol. 108, No 1, p. 173-206. ISSN 0074-7742. Available from: https://dx.doi.org/10.1016/B978-0-12-410499-0.00007-1. |
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@article{1126372,
author = {Dubový, Petr and Jančálek, Radim and Kubek, Tomáš},
article_location = {San Diego},
article_number = {1},
doi = {http://dx.doi.org/10.1016/B978-0-12-410499-0.00007-1},
keywords = {Wallerian degeneration; Neuroinflammation; Immune cells; Inflammatory mediators; Cytokines; Axonal regeneration},
language = {eng},
issn = {0074-7742},
journal = {International Review of Neurobiology},
title = {Role of Inflammation and Cytokines in Peripheral Nerve Regeneration},
url = {http://www.sciencedirect.com/science/article/pii/B9780124104990000071},
volume = {108},
year = {2013}
}
TY - JOUR
ID - 1126372
AU - Dubový, Petr - Jančálek, Radim - Kubek, Tomáš
PY - 2013
TI - Role of Inflammation and Cytokines in Peripheral Nerve Regeneration
JF - International Review of Neurobiology
VL - 108
IS - 1
SP - 173-206
EP - 173-206
PB - Elsevier Inc.
SN - 00747742
KW - Wallerian degeneration
KW - Neuroinflammation
KW - Immune cells
KW - Inflammatory mediators
KW - Cytokines
KW - Axonal regeneration
UR - http://www.sciencedirect.com/science/article/pii/B9780124104990000071
N2 - This work provides a review of immune reactions involved in classic as well as alternative methods of peripheral nerve regeneration, and mainly with a view to understanding their beneficial effects. Axonal degeneration distal to nerve damage triggers a cascade of inflammatory events alongside injured nerve fibers known as Wallerian degeneration (WD). The early inflammatory reactions of WD comprise the complement system, arachidonic acid metabolites, and inflammatory mediators that are related to myelin fragmentation and activation of Schwann cells. Fine-tuned upregulation of the cytokine/chemokine network by Schwann cells activates resident and hematogenous macrophages to complete the clearance of axonal and myelin debris and stimulate regrowth of axonal sprouts. In addition to local effects, immune reactions of neuronal bodies and glial cells are also implicated in the survival and conditioning of neurons to regenerate severed nerves. Understanding of the cellular and molecular interactions between the immune system and peripheral nerve injury opens new possibilities for targeting inflammatory mediators to improve functional reinnervation.
ER -
DUBOVÝ, Petr, Radim JANČÁLEK and Tomáš KUBEK. Role of Inflammation and Cytokines in Peripheral Nerve Regeneration. \textit{International Review of Neurobiology}. San Diego: Elsevier Inc., 2013, vol.~108, No~1, p.~173-206. ISSN~0074-7742. Available from: https://dx.doi.org/10.1016/B978-0-12-410499-0.00007-1.
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