Intracranial EEG seizure onset patterns in unilateral temporal
lobe epilepsy and their relationship to other variables

J 2013

Intracranial EEG seizure onset patterns in unilateral temporal lobe epilepsy and their relationship to other variables

DOLEŽALOVÁ, Irena, Milan BRÁZDIL, Markéta HERMANOVÁ, Iva HORÁKOVÁ, Ivan REKTOR et. al.

Basic information

Original name

Intracranial EEG seizure onset patterns in unilateral temporal lobe epilepsy and their relationship to other variables

Authors

DOLEŽALOVÁ, Irena (203 Czech Republic, guarantor, belonging to the institution), Milan BRÁZDIL (203 Czech Republic, belonging to the institution), Markéta HERMANOVÁ (203 Czech Republic, belonging to the institution), Iva HORÁKOVÁ (203 Czech Republic, belonging to the institution), Ivan REKTOR (203 Czech Republic, belonging to the institution) and Robert KUBA (203 Czech Republic, belonging to the institution)

Edition

Clinical Neurophysiology, Clare, Ireland, Elsevier Ireland, 2013, 1388-2457

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.979

RIV identification code

RIV/00216224:14740/13:00066437

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1016/j.clinph.2012.12.046

UT WoS

000319041600008

Keywords in English

Temporal lobe epilepsy; Invasive EEG; Outcome; Histopathology; Localization; Frequency; Predictive factors

Abstract

V originále

Objective: We performed a retrospective study to determine the different types of seizure onset patterns (SOP) in invasive EEG (IEEG) in patients with temporal lobe epilepsy (TLE). Methods: We analyzed a group of 51 patients (158 seizures) with TLE who underwent IEEG. We analyzed the dominant frequency during the first 3 s after the onset of ictal activity. The cut-off value for distinguishing between fast and slow frequencies was 8 Hz. We defined three types of SOPs: (1) fast ictal activity (FIA) - frequency >= 8 Hz; (2) slow ictal activity (SIA) - frequency <8 Hz; and (3) attenuation of background activity (AT) - no clear-cut rhythmic activity during the first 3 s associated with changes of IEEG signal (increase of frequency, decrease of amplitude). We tried to find the relationship between different SOP types and surgery outcome, histopathological findings, and SOZ localization. Results: The most frequent SOP was FIA, which was present in 67% of patients. More patients with FIA were classified postoperatively as Engel I than those with SIA and AT (85% vs. 31% vs. 0) (P < 0.001). There were no statistically significant differences in the type of SOP, in the histopathological findings, or in the SOZ localization. Conclusion: In patients with refractory TLE, seizure onset frequencies >= 8 Hz during the first 3 s of ictal activity are associated with a better surgical outcome than frequencies <8 Hz. Significance: Our study suggests that very early seizure onset frequencies in IEEG in patients with TLE could be the independent predictive factor for their outcome, regardless of the localization and etiology.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

GAP304/11/1318, research and development project

Name: Optimalizace metodiky analýzy a hodnocení simultánního EEG-fMRI u pacientů s farmakorezistentní epilepsií

Investor: Czech Science Foundation

Citovat

DOLEŽALOVÁ, Irena, Milan BRÁZDIL, Markéta HERMANOVÁ, Iva HORÁKOVÁ, Ivan REKTOR and Robert KUBA. Intracranial EEG seizure onset patterns in unilateral temporal lobe epilepsy and their relationship to other variables. Clinical Neurophysiology. Clare, Ireland: Elsevier Ireland, 2013, vol. 124, No 6, p. 1079-1088. ISSN 1388-2457. Available from: https://dx.doi.org/10.1016/j.clinph.2012.12.046.

@article{1126482,
   author = {Doležalová, Irena and Brázdil, Milan and Hermanová, Markéta and Horáková, Iva and Rektor, Ivan and Kuba, Robert},
   article_location = {Clare, Ireland},
   article_number = {6},
   doi = {http://dx.doi.org/10.1016/j.clinph.2012.12.046},
   keywords = {Temporal lobe epilepsy; Invasive EEG; Outcome; Histopathology; Localization; Frequency; Predictive factors},
   language = {eng},
   issn = {1388-2457},
   journal = {Clinical Neurophysiology},
   title = {Intracranial EEG seizure onset patterns in unilateral temporal lobe epilepsy and their relationship to other variables},
   url = {http://europepmc.org/abstract/MED/23415861},
   volume = {124},
   year = {2013}
}

TY  - JOUR
ID  - 1126482
AU  - Doležalová, Irena - Brázdil, Milan - Hermanová, Markéta - Horáková, Iva - Rektor, Ivan - Kuba, Robert
PY  - 2013
TI  - Intracranial EEG seizure onset patterns in unilateral temporal lobe epilepsy and their relationship to other variables
JF  - Clinical Neurophysiology
VL  - 124
IS  - 6
SP  - 1079-1088
EP  - 1079-1088
PB  - Elsevier Ireland
SN  - 13882457
KW  - Temporal lobe epilepsy
KW  - Invasive EEG
KW  - Outcome
KW  - Histopathology
KW  - Localization
KW  - Frequency
KW  - Predictive factors
UR  - http://europepmc.org/abstract/MED/23415861
L2  - http://europepmc.org/abstract/MED/23415861
N2  - Objective: We performed a retrospective study to determine the different types of seizure onset patterns (SOP) in invasive EEG (IEEG) in patients with temporal lobe epilepsy (TLE). Methods: We analyzed a group of 51 patients (158 seizures) with TLE who underwent IEEG. We analyzed the dominant frequency during the first 3 s after the onset of ictal activity. The cut-off value for distinguishing between fast and slow frequencies was 8 Hz. We defined three types of SOPs: (1) fast ictal activity (FIA) - frequency >= 8 Hz; (2) slow ictal activity (SIA) - frequency <8 Hz; and (3) attenuation of background activity (AT) - no clear-cut rhythmic activity during the first 3 s associated with changes of IEEG signal (increase of frequency, decrease of amplitude). We tried to find the relationship between different SOP types and surgery outcome, histopathological findings, and SOZ localization. Results: The most frequent SOP was FIA, which was present in 67% of patients. More patients with FIA were classified postoperatively as Engel I than those with SIA and AT (85% vs. 31% vs. 0) (P < 0.001). There were no statistically significant differences in the type of SOP, in the histopathological findings, or in the SOZ localization. Conclusion: In patients with refractory TLE, seizure onset frequencies >= 8 Hz during the first 3 s of ictal activity are associated with a better surgical outcome than frequencies <8 Hz. Significance: Our study suggests that very early seizure onset frequencies in IEEG in patients with TLE could be the independent predictive factor for their outcome, regardless of the localization and etiology.
ER  -

DOLEŽALOVÁ, Irena, Milan BRÁZDIL, Markéta HERMANOVÁ, Iva HORÁKOVÁ, Ivan REKTOR and Robert KUBA. Intracranial EEG seizure onset patterns in unilateral temporal lobe epilepsy and their relationship to other variables. \textit{Clinical Neurophysiology}. Clare, Ireland: Elsevier Ireland, 2013, vol.~124, No~6, p.~1079-1088. ISSN~1388-2457. Available from: https://dx.doi.org/10.1016/j.clinph.2012.12.046.

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