The Mechanisms of Movement Control and Time Estimation in
Cervical Dystonia Patients

J 2013

The Mechanisms of Movement Control and Time Estimation in Cervical Dystonia Patients

FILIP, Pavel, Ovidiu V. LUNGU, Daniel Joel SHAW, Tomáš KAŠPÁREK, Martin BAREŠ et. al.

Basic information

Original name

The Mechanisms of Movement Control and Time Estimation in Cervical Dystonia Patients

Authors

FILIP, Pavel (703 Slovakia, belonging to the institution), Ovidiu V. LUNGU (124 Canada), Daniel Joel SHAW (826 United Kingdom of Great Britain and Northern Ireland, belonging to the institution), Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution) and Martin BAREŠ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Neural Plasticity, New York, HINDAWI PUBLISHING CORPORATION, 2013, 2090-5904

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.608

RIV identification code

RIV/00216224:14740/13:00065632

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1155/2013/908741

UT WoS

000325567500001

Keywords in English

cervical dystonia; cerebellar signs; basal ganglia

Abstract

V originále

Traditionally, the pathophysiology of cervical dystonia has been regarded mainly in relation to neurochemical abnormities in the basal ganglia. Recently, however, substantial evidence has emerged for cerebellar involvement. While the absence of neurological “cerebellar signs” in most dystonia patients may be considered at least provoking, there are more subtle indications of cerebellar dysfunction in complex, demanding tasks. Specifically, given the role of the cerebellum in the neural representation of time, in the millisecond range, dysfunction to this structure is considered to be of greater importance than dysfunction of the basal ganglia. In the current study,we investigated the performance of cervical dystonia patients on a computer task known to engage the cerebellum, namely, the interception of a moving target with changing parameters (speed, acceleration, and angle) with a simple response (pushing a button). The cervical dystonia patients achieved significantly worse results than a sample of healthy controls. Our results suggest that the cervical dystonia patients are impaired at integrating incoming visual information with motor responses during the prediction of upcoming actions, an impairment we interpret as evidence of cerebellar dysfunction.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

NT13437, research and development project

Name: Mozeček, kognitivní dysfunkce a mechanismy kontroly pohybu a odhadu času u dystonie a schizofrenie.

Files attached

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Citovat

FILIP, Pavel, Ovidiu V. LUNGU, Daniel Joel SHAW, Tomáš KAŠPÁREK and Martin BAREŠ. The Mechanisms of Movement Control and Time Estimation in Cervical Dystonia Patients. Neural Plasticity. New York: HINDAWI PUBLISHING CORPORATION, 2013, Neuveden, Oct, p. "nestránkováno", 10 pp. ISSN 2090-5904. Available from: https://dx.doi.org/10.1155/2013/908741.

@article{1126486,
   author = {Filip, Pavel and Lungu, Ovidiu V. and Shaw, Daniel Joel and Kašpárek, Tomáš and Bareš, Martin},
   article_location = {New York},
   article_number = {Oct},
   doi = {http://dx.doi.org/10.1155/2013/908741},
   keywords = {cervical dystonia; cerebellar signs; basal ganglia},
   language = {eng},
   issn = {2090-5904},
   journal = {Neural Plasticity},
   title = {The Mechanisms of Movement Control and Time Estimation in Cervical Dystonia Patients},
   url = {http://www.hindawi.com/journals/np/2013/908741/},
   volume = {Neuveden},
   year = {2013}
}

TY  - JOUR
ID  - 1126486
AU  - Filip, Pavel - Lungu, Ovidiu V. - Shaw, Daniel Joel - Kašpárek, Tomáš - Bareš, Martin
PY  - 2013
TI  - The Mechanisms of Movement Control and Time Estimation in Cervical Dystonia Patients
JF  - Neural Plasticity
VL  - Neuveden
IS  - Oct
SP  - "nestránkováno"
EP  - "nestránkováno"
PB  - HINDAWI PUBLISHING CORPORATION
SN  - 20905904
KW  - cervical dystonia
KW  - cerebellar signs
KW  - basal ganglia
UR  - http://www.hindawi.com/journals/np/2013/908741/
L2  - http://www.hindawi.com/journals/np/2013/908741/
N2  - Traditionally, the pathophysiology of cervical dystonia has been regarded mainly in relation to neurochemical abnormities in the basal ganglia. Recently, however, substantial evidence has emerged for cerebellar involvement. While the absence of neurological “cerebellar signs” in most dystonia patients may be considered at least provoking, there are more subtle indications of cerebellar dysfunction in complex, demanding tasks. Specifically, given the role of the cerebellum in the neural representation of time, in the millisecond range, dysfunction to this structure is considered to be of greater importance than dysfunction of the basal ganglia. In the current study,we investigated the performance of cervical dystonia patients on a computer task known to engage the cerebellum, namely, the interception of a moving target with changing parameters (speed, acceleration, and angle) with a simple response (pushing a button). The cervical dystonia patients achieved significantly worse results than a sample of healthy controls. Our results suggest that the cervical dystonia patients are impaired at integrating incoming visual information with motor responses during the prediction of upcoming actions, an impairment we interpret as evidence of cerebellar dysfunction.
ER  -

FILIP, Pavel, Ovidiu V. LUNGU, Daniel Joel SHAW, Tomáš KAŠPÁREK and Martin BAREŠ. The Mechanisms of Movement Control and Time Estimation in Cervical Dystonia Patients. \textit{Neural Plasticity}. New York: HINDAWI PUBLISHING CORPORATION, 2013, Neuveden, Oct, p.~''nestránkováno'', 10 pp. ISSN~2090-5904. Available from: https://dx.doi.org/10.1155/2013/908741.

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