The Mechanisms of Movement Control and Time Estimation in Cervical Dystonia Patients

FILIP, Pavel, Ovidiu V. LUNGU, Daniel Joel SHAW, Tomáš KAŠPÁREK and Martin BAREŠ. The Mechanisms of Movement Control and Time Estimation in Cervical Dystonia Patients. Neural Plasticity. New York: HINDAWI PUBLISHING CORPORATION, 2013, Neuveden, Oct, p. "nestránkováno", 10 pp. ISSN 2090-5904. Available from: https://dx.doi.org/10.1155/2013/908741.

Basic information

• Original name: The Mechanisms of Movement Control and Time Estimation in Cervical Dystonia Patients
• Authors: FILIP, Pavel (703 Slovakia, belonging to the institution), Ovidiu V. LUNGU (124 Canada), Daniel Joel SHAW (826 United Kingdom of Great Britain and Northern Ireland, belonging to the institution), Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution) and Martin BAREŠ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Neural Plasticity, New York, HINDAWI PUBLISHING CORPORATION, 2013, 2090-5904.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 3.608
• RIV identification code: RIV/00216224:14740/13:00065632
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1155/2013/908741
• UT WoS: 000325567500001
• Keywords in English: cervical dystonia; cerebellar signs; basal ganglia
• Tags: ok, rivok
• Tags: International impact, Reviewed

Abstract

Traditionally, the pathophysiology of cervical dystonia has been regarded mainly in relation to neurochemical abnormities in the basal ganglia. Recently, however, substantial evidence has emerged for cerebellar involvement. While the absence of neurological “cerebellar signs” in most dystonia patients may be considered at least provoking, there are more subtle indications of cerebellar dysfunction in complex, demanding tasks. Specifically, given the role of the cerebellum in the neural representation of time, in the millisecond range, dysfunction to this structure is considered to be of greater importance than dysfunction of the basal ganglia. In the current study,we investigated the performance of cervical dystonia patients on a computer task known to engage the cerebellum, namely, the interception of a moving target with changing parameters (speed, acceleration, and angle) with a simple response (pushing a button). The cervical dystonia patients achieved significantly worse results than a sample of healthy controls. Our results suggest that the cervical dystonia patients are impaired at integrating incoming visual information with motor responses during the prediction of upcoming actions, an impairment we interpret as evidence of cerebellar dysfunction.

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology
• NT13437, research and development project: Name: Mozeček, kognitivní dysfunkce a mechanismy kontroly pohybu a odhadu času u dystonie a schizofrenie.