Association Between the Basal Ganglia and Large-Scale Brain
Networks in Epilepsy

J 2013

Association Between the Basal Ganglia and Large-Scale Brain Networks in Epilepsy

REKTOR, Ivan, Jan TOMČÍK, Michal MIKL, Radek MAREČEK, Milan BRÁZDIL et. al.

Basic information

Original name

Association Between the Basal Ganglia and Large-Scale Brain Networks in Epilepsy

Authors

REKTOR, Ivan (203 Czech Republic, guarantor, belonging to the institution), Jan TOMČÍK (203 Czech Republic), Michal MIKL (203 Czech Republic, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Milan BRÁZDIL (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, belonging to the institution)

Edition

BRAIN TOPOGRAPHY, DORDRECHT, SPRINGER, 2013, 0896-0267

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.519

RIV identification code

RIV/00216224:14740/13:00066443

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1007/s10548-012-0272-8

UT WoS

000323910200012

Keywords in English

Basal ganglia; Putamen; Epilepsy; Default mode network; Somatomotor cortex; correlation

Abstract

V originále

Epilepsy may affect connectivity between the putamen and cortex even during the resting state. Putamen is part of the basal ganglia resting state network (BG-RSN) which is anti-correlated with the default mode network (DMN) in healthy subjects. Therefore, we aimed at studying the functional brain connectivity (FC) of the putamen with the cortical areas engaged in theDMNas well as with the primary somatomotor cortex which is a cortical region engaged in the BG-RSN. We compared the data obtained in patients with epilepsy with that in healthy controls (HC). Functional magnetic resonance imaging (fMRI) was performed in 10 HC and 24 patients with epilepsy: 14 patients with extratemporal epilepsy (PE) and 10 patients with temporal epilepsy (PT). Resting state fMRI datawas obtained using the 1.5 T Siemens Symphony scanner. TheGroup ICA of fMRI Toolbox (GIFT) program was used for independent component analysis. The component representing the DMN was chosen according to a spatial correlation with a mask typical for DMN. The FC between the putamen and the primary somatomotor cortex was studied to assess the connectivity of the putamen within the BG-RSN. A second-level analysis was calculated to evaluate differences among the groups using SPM software. In patients with epilepsy as compared toHC, the magnitude of anti-correlation between the putamen and brain regions engaged in the DMN was significantly lower. In fact, the correlation changed the connectivity direction from negative inHC to positive in PE and PT. The disturbed FC of the BG in patients with epilepsy as compared with HC was further illustrated by a significant decrease in connectivity between the left/right putamen and the left/right somatomotor cortex, i.e. between regions that are engaged in the BG-RSN. The FC between the putamen and the cortex is disturbed in patients with epilepsy.Thismay reflect an altered function of theBGin epilepsy.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

GAP304/11/1318, research and development project

Name: Optimalizace metodiky analýzy a hodnocení simultánního EEG-fMRI u pacientů s farmakorezistentní epilepsií

Investor: Czech Science Foundation

Citovat

REKTOR, Ivan, Jan TOMČÍK, Michal MIKL, Radek MAREČEK, Milan BRÁZDIL and Irena REKTOROVÁ. Association Between the Basal Ganglia and Large-Scale Brain Networks in Epilepsy. BRAIN TOPOGRAPHY. DORDRECHT: SPRINGER, 2013, vol. 26, No 2, p. 355-362. ISSN 0896-0267. Available from: https://dx.doi.org/10.1007/s10548-012-0272-8.

@article{1126801,
   author = {Rektor, Ivan and Tomčík, Jan and Mikl, Michal and Mareček, Radek and Brázdil, Milan and Rektorová, Irena},
   article_location = {DORDRECHT},
   article_number = {2},
   doi = {http://dx.doi.org/10.1007/s10548-012-0272-8},
   keywords = {Basal ganglia; Putamen; Epilepsy; Default mode network; Somatomotor cortex; correlation},
   language = {eng},
   issn = {0896-0267},
   journal = {BRAIN TOPOGRAPHY},
   title = {Association Between the Basal Ganglia and Large-Scale Brain Networks in Epilepsy},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/23400553},
   volume = {26},
   year = {2013}
}

TY  - JOUR
ID  - 1126801
AU  - Rektor, Ivan - Tomčík, Jan - Mikl, Michal - Mareček, Radek - Brázdil, Milan - Rektorová, Irena
PY  - 2013
TI  - Association Between the Basal Ganglia and Large-Scale Brain Networks in Epilepsy
JF  - BRAIN TOPOGRAPHY
VL  - 26
IS  - 2
SP  - 355-362
EP  - 355-362
PB  - SPRINGER
SN  - 08960267
KW  - Basal ganglia
KW  - Putamen
KW  - Epilepsy
KW  - Default mode network
KW  - Somatomotor cortex
KW  - correlation
UR  - http://www.ncbi.nlm.nih.gov/pubmed/23400553
L2  - http://www.ncbi.nlm.nih.gov/pubmed/23400553
N2  - Epilepsy may affect connectivity between the putamen and cortex even during the resting state. Putamen is part of the basal ganglia resting state network (BG-RSN) which is anti-correlated with the default mode network (DMN) in healthy subjects. Therefore, we aimed at studying the functional brain connectivity (FC) of the putamen with the cortical areas engaged in theDMNas well as with the primary somatomotor cortex which is a cortical region engaged in the BG-RSN. We compared the data obtained in patients with epilepsy with that in healthy controls (HC). Functional magnetic resonance imaging (fMRI) was performed in 10 HC and 24 patients with epilepsy: 14 patients with extratemporal epilepsy (PE) and 10 patients with temporal epilepsy (PT). Resting state fMRI datawas obtained using the 1.5 T Siemens Symphony scanner. TheGroup ICA of fMRI Toolbox (GIFT) program was used for independent component analysis. The component representing the DMN was chosen according to a spatial correlation with a mask typical for DMN. The FC between the putamen and the primary somatomotor cortex was studied to assess the connectivity of the putamen within the BG-RSN. A second-level analysis was calculated to evaluate differences among the groups using SPM software. In patients with epilepsy as compared toHC, the magnitude of anti-correlation between the putamen and brain regions engaged in the DMN was significantly lower. In fact, the correlation changed the connectivity direction from negative inHC to positive in PE and PT. The disturbed FC of the BG in patients with epilepsy as compared with HC was further illustrated by a significant decrease in connectivity between the left/right putamen and the left/right somatomotor cortex, i.e. between regions that are engaged in the BG-RSN. The FC between the putamen and the cortex is disturbed in patients with epilepsy.Thismay reflect an altered function of theBGin epilepsy.
ER  -

REKTOR, Ivan, Jan TOMČÍK, Michal MIKL, Radek MAREČEK, Milan BRÁZDIL and Irena REKTOROVÁ. Association Between the Basal Ganglia and Large-Scale Brain Networks in Epilepsy. \textit{BRAIN TOPOGRAPHY}. DORDRECHT: SPRINGER, 2013, vol.~26, No~2, p.~355-362. ISSN~0896-0267. Available from: https://dx.doi.org/10.1007/s10548-012-0272-8.

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