Expression of FGF19 in Human Embryonic Stem Cells

KREJČÍ, Pavel, Michaela KUNOVÁ, Iva KUBÍKOVÁ, Lukáš TRANTÍREK, Alois KOZUBÍK and Petr DVOŘÁK. Expression of FGF19 in Human Embryonic Stem Cells. STEM CELLS. HOBOKEN: WILEY-BLACKWELL, 2013, vol. 31, No 11, p. 2582-2584. ISSN 1066-5099. Available from: https://dx.doi.org/10.1002/stem.1493.

Basic information

• Original name: Expression of FGF19 in Human Embryonic Stem Cells
• Authors: KREJČÍ, Pavel (203 Czech Republic, belonging to the institution), Michaela KUNOVÁ (203 Czech Republic, belonging to the institution), Iva KUBÍKOVÁ (203 Czech Republic, belonging to the institution), Lukáš TRANTÍREK (203 Czech Republic, belonging to the institution), Alois KOZUBÍK (203 Czech Republic, belonging to the institution) and Petr DVOŘÁK (203 Czech Republic, guarantor, belonging to the institution).
• Edition: STEM CELLS, HOBOKEN, WILEY-BLACKWELL, 2013, 1066-5099.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: Genetics and molecular biology
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 7.133
• RIV identification code: RIV/00216224:14110/13:00066459
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1002/stem.1493
• UT WoS: 000327025600027
• Keywords in English: Cell signaling; Embryonic stem cells; FGF19; Fibroblast growth factor; Expression
• Tags: International impact, Reviewed

Abstract

In human embryonic stem cells, continuous stimulation with fibroplast growthfactor 2 is required for self-renewal. inhibition of FGF2 signaling results in rapid differentiation, further underscoring the importance of FGF system in maintenance of hESC undifferentiated state. In addition to FGF2, human FGF family contains 17 members which presence in hESC remains unclear, with exception of FGF4.

Links

• GAP305/11/0752, research and development project: Name: Molekulární základy FGFR3 signalingu v kostní dysplázii

Investor: Czech Science Foundation

• LH12004, research and development project: Name: FGFR3-specifický adaptérom a jeho role v patologické FGFR3 signalizaci v nemoci (Acronym: AMVIS-FGFR3)

Investor: Ministry of Education, Youth and Sports of the CR

• MSM0021622430, plan (intention): Name: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie

Investor: Ministry of Education, Youth and Sports of the CR, Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies

• MUNI/M/0071/2013, interní kód MU: Name: High-throughput screening of compound libraries aimed on discovery of novel inhibitors of the FGFR/ERK MAP kinase signaling (Acronym: HTS-FGFR)

Investor: Masaryk University, INTERDISCIPLINARY - Interdisciplinary research projects