| VRIENDT, Veerle De, Wendy De ROOCK, Antonio Fabio Di NARZO, Sun TIAN, Bart BIESMANS, Bart JACOBS, Eva BUDINSKÁ, Xavier SAGAERT, Simona ROSSI, Giovanni D´ARIO, Mauro DELORENZI, Iris SIMON, Loredana VECCHIONE a Sabine TEJPAR. DUSP 4 expression identifies a subset of colorectal cancer tumors that differ in MAPK activation, regardless of the genotype. Biomarkers. Spojené státy americké: INFORMA HEALTHCARE, 2013, roč. 18, č. 6, s. 516-524. ISSN 1354-750X. Dostupné z: https://dx.doi.org/10.3109/1354750X.2013.819038. |
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@article{1127158,
author = {Vriendt, Veerle De and Roock, Wendy De and Narzo, Antonio Fabio Di and Tian, Sun and Biesmans, Bart and Jacobs, Bart and Budinská, Eva and Sagaert, Xavier and Rossi, Simona and D´Ario, Giovanni and Delorenzi, Mauro and Simon, Iris and Vecchione, Loredana and Tejpar, Sabine},
article_location = {Spojené státy americké},
article_number = {6},
doi = {http://dx.doi.org/10.3109/1354750X.2013.819038},
keywords = {Colorectal cancer; gene expression; MAPK pathway},
language = {eng},
issn = {1354-750X},
journal = {Biomarkers},
title = {DUSP 4 expression identifies a subset of colorectal cancer tumors that differ in MAPK activation, regardless of the genotype},
volume = {18},
year = {2013}
}
TY - JOUR
ID - 1127158
AU - Vriendt, Veerle De - Roock, Wendy De - Narzo, Antonio Fabio Di - Tian, Sun - Biesmans, Bart - Jacobs, Bart - Budinská, Eva - Sagaert, Xavier - Rossi, Simona - D´Ario, Giovanni - Delorenzi, Mauro - Simon, Iris - Vecchione, Loredana - Tejpar, Sabine
PY - 2013
TI - DUSP 4 expression identifies a subset of colorectal cancer tumors that differ in MAPK activation, regardless of the genotype
JF - Biomarkers
VL - 18
IS - 6
SP - 516-524
EP - 516-524
PB - INFORMA HEALTHCARE
SN - 1354750X
KW - Colorectal cancer
KW - gene expression
KW - MAPK pathway
N2 - As dual-specificity phosphatase (DUSP) expression has been correlated to sensitivity to MEK inhibitors, DUSP expression levels may indicate activation of the mitogen-activated protein kinase (MAPK) pathway in many tumor types. In this study, we investigate if DUSP levels can indicate different levels of MAPK activation within colorectal cancer (CRC) patients. In three different CRC patient microarray datasets, we analyzed the expression of DUSP1, DUSP4 and DUSP6 according to mutational status, their correlation with survival and their association with different clinical characteristics. DUSP4 was significantly differentially expressed between all mutational subgroups with the highest expression in BRAF mutated tumors. Moreover, high DUSP4 expression was associated with a worse overall survival and with clinical characteristics typical for BRAF mutant patients. The use of DUSP expression as a predictive biomarker towards MAPK targeted therapy in CRC patients needs further investigation.
ER -
VRIENDT, Veerle De, Wendy De ROOCK, Antonio Fabio Di NARZO, Sun TIAN, Bart BIESMANS, Bart JACOBS, Eva BUDINSKÁ, Xavier SAGAERT, Simona ROSSI, Giovanni D´ARIO, Mauro DELORENZI, Iris SIMON, Loredana VECCHIONE a Sabine TEJPAR. DUSP 4 expression identifies a subset of colorectal cancer tumors that differ in MAPK activation, regardless of the genotype. \textit{Biomarkers}. Spojené státy americké: INFORMA HEALTHCARE, 2013, roč.~18, č.~6, s.~516-524. ISSN~1354-750X. Dostupné z: https://dx.doi.org/10.3109/1354750X.2013.819038.
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