HUSÁROVÁ, Ivica, Michal MIKL, Ovidiu V. LUNGU, Radek MAREČEK, Jiří VANÍČEK and Martin BAREŠ. Similar circuits but different connectivity patterns between the cerebellum, Basal Ganglia, and supplementary motor area in early Parkinson's disease patients and controls during predictive motor timing. Journal of Neuroimaging. Hoboken, USA: WILEY-BLACKWELL, vol. 23, No 4, p. 452-462. ISSN 1051-2284. doi:10.1111/jon.12030. 2013.
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Basic information
Original name Similar circuits but different connectivity patterns between the cerebellum, Basal Ganglia, and supplementary motor area in early Parkinson's disease patients and controls during predictive motor timing
Authors HUSÁROVÁ, Ivica (703 Slovakia, belonging to the institution), Michal MIKL (203 Czech Republic, belonging to the institution), Ovidiu V. LUNGU (124 Canada), Radek MAREČEK (203 Czech Republic, belonging to the institution), Jiří VANÍČEK (203 Czech Republic, belonging to the institution) and Martin BAREŠ (203 Czech Republic, guarantor, belonging to the institution).
Edition Journal of Neuroimaging, Hoboken, USA, WILEY-BLACKWELL, 2013, 1051-2284.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 1.818
RIV identification code RIV/00216224:14740/13:00069968
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1111/jon.12030
Keywords in English Basal ganglia; Parkinson's disease; cerebellum; connectivity; cortical reorganization; motor timing; prediction; supplementary motor area
Tags ok, rivok
Tags International impact, Reviewed
Changed by Changed by: Olga Křížová, učo 56639. Changed: 4/4/2014 10:52.
Abstract
The cerebellum, basal ganglia (BG), and other cortical regions, such as supplementary motor area (SMA) have emerged as important structures dealing with various aspects of timing, yet the modulation of functional connectivity between them during motor timing tasks remains unexplored. METHODS: We used dynamic causal modeling to investigate the differences in effective connectivity (EC) between these regions and its modulation by behavioral outcome during a motor timing prediction task in a group of 16 patients with early Parkinson's disease (PD) and 17 healthy controls. Behavioral events (hits and errors) constituted the driving input connected to the cerebellum, and the modulation in connectivity was assessed relative to the hit condition (successful interception of target). RESULTS: The driving input elicited response in the target area, while modulatory input changed the specific connection strength. The neuroimaging data revealed similar structure of intrinsic connectivity in both groups with unidirectional connections from cerebellum to both sides of the BG, from BG to the SMA, and then from SMA to the cerebellum. However, the type of intrinsic connection was different between two groups. In the PD group, the connection between the SMA and cerebellum was inhibitory in comparison to the HC group, where the connection was activated. Furthermore, the modulation of connectivity by the performance in the task was different between the two groups, with decreased connectivity between the cerebellum and left BG and SMA and a more pronounced symmetry of these connections in controls. In the same time, there was an increased EC between the cerebellum and both sides of BG with more pronounced asymmetry (stronger connection with left BG) in patients. In addition, in the PD group the modulatory input strengthened inhibitory connectivity between the SMA and the cerebellum, while in the HC group the excitatory connection was slightly strengthened. CONCLUSIONS: Our findings indicate that although early PD subjects and controls use similar functional circuits to maintain a successful outcome in predictive motor timing behavior, the type and strength of EC and its modulation by behavioral performance differ between these two groups. These functional differences might represent the first step of cortical reorganization aimed at maintaining a normal performance in the brain affected by early Parkinson's disease and may have implications for the neuro-rehabilitation field.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
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