Similar circuits but different connectivity patterns between
the cerebellum, Basal Ganglia, and supplementary motor area in
early Parkinson's disease patients and controls during
predictive motor timing

J 2013

Similar circuits but different connectivity patterns between the cerebellum, Basal Ganglia, and supplementary motor area in early Parkinson's disease patients and controls during predictive motor timing

HUSÁROVÁ, Ivica, Michal MIKL, Ovidiu V. LUNGU, Radek MAREČEK, Jiří VANÍČEK et. al.

Basic information

Original name

Similar circuits but different connectivity patterns between the cerebellum, Basal Ganglia, and supplementary motor area in early Parkinson's disease patients and controls during predictive motor timing

Authors

HUSÁROVÁ, Ivica (703 Slovakia, belonging to the institution), Michal MIKL (203 Czech Republic, belonging to the institution), Ovidiu V. LUNGU (124 Canada), Radek MAREČEK (203 Czech Republic, belonging to the institution), Jiří VANÍČEK (203 Czech Republic, belonging to the institution) and Martin BAREŠ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Journal of Neuroimaging, Hoboken, USA, WILEY-BLACKWELL, 2013, 1051-2284

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.818

RIV identification code

RIV/00216224:14740/13:00069968

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1111/jon.12030

Keywords in English

Basal ganglia; Parkinson's disease; cerebellum; connectivity; cortical reorganization; motor timing; prediction; supplementary motor area

Abstract

V originále

The cerebellum, basal ganglia (BG), and other cortical regions, such as supplementary motor area (SMA) have emerged as important structures dealing with various aspects of timing, yet the modulation of functional connectivity between them during motor timing tasks remains unexplored. METHODS: We used dynamic causal modeling to investigate the differences in effective connectivity (EC) between these regions and its modulation by behavioral outcome during a motor timing prediction task in a group of 16 patients with early Parkinson's disease (PD) and 17 healthy controls. Behavioral events (hits and errors) constituted the driving input connected to the cerebellum, and the modulation in connectivity was assessed relative to the hit condition (successful interception of target). RESULTS: The driving input elicited response in the target area, while modulatory input changed the specific connection strength. The neuroimaging data revealed similar structure of intrinsic connectivity in both groups with unidirectional connections from cerebellum to both sides of the BG, from BG to the SMA, and then from SMA to the cerebellum. However, the type of intrinsic connection was different between two groups. In the PD group, the connection between the SMA and cerebellum was inhibitory in comparison to the HC group, where the connection was activated. Furthermore, the modulation of connectivity by the performance in the task was different between the two groups, with decreased connectivity between the cerebellum and left BG and SMA and a more pronounced symmetry of these connections in controls. In the same time, there was an increased EC between the cerebellum and both sides of BG with more pronounced asymmetry (stronger connection with left BG) in patients. In addition, in the PD group the modulatory input strengthened inhibitory connectivity between the SMA and the cerebellum, while in the HC group the excitatory connection was slightly strengthened. CONCLUSIONS: Our findings indicate that although early PD subjects and controls use similar functional circuits to maintain a successful outcome in predictive motor timing behavior, the type and strength of EC and its modulation by behavioral performance differ between these two groups. These functional differences might represent the first step of cortical reorganization aimed at maintaining a normal performance in the brain affected by early Parkinson's disease and may have implications for the neuro-rehabilitation field.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

Citovat

HUSÁROVÁ, Ivica, Michal MIKL, Ovidiu V. LUNGU, Radek MAREČEK, Jiří VANÍČEK and Martin BAREŠ. Similar circuits but different connectivity patterns between the cerebellum, Basal Ganglia, and supplementary motor area in early Parkinson's disease patients and controls during predictive motor timing. Journal of Neuroimaging. Hoboken, USA: WILEY-BLACKWELL, 2013, vol. 23, No 4, p. 452-462. ISSN 1051-2284. Available from: https://dx.doi.org/10.1111/jon.12030.

@article{1127728,
   author = {Husárová, Ivica and Mikl, Michal and Lungu, Ovidiu V. and Mareček, Radek and Vaníček, Jiří and Bareš, Martin},
   article_location = {Hoboken, USA},
   article_number = {4},
   doi = {http://dx.doi.org/10.1111/jon.12030},
   keywords = {Basal ganglia; Parkinson's disease; cerebellum; connectivity; cortical reorganization; motor timing; prediction; supplementary motor area},
   language = {eng},
   issn = {1051-2284},
   journal = {Journal of Neuroimaging},
   title = {Similar circuits but different connectivity patterns between the cerebellum, Basal Ganglia, and supplementary motor area in early Parkinson's disease patients and controls during predictive motor timing},
   url = {http://onlinelibrary.wiley.com/doi/10.1111/jon.12030/pdf},
   volume = {23},
   year = {2013}
}

TY  - JOUR
ID  - 1127728
AU  - Husárová, Ivica - Mikl, Michal - Lungu, Ovidiu V. - Mareček, Radek - Vaníček, Jiří - Bareš, Martin
PY  - 2013
TI  - Similar circuits but different connectivity patterns between the cerebellum, Basal Ganglia, and supplementary motor area in early Parkinson's disease patients and controls during predictive motor timing
JF  - Journal of Neuroimaging
VL  - 23
IS  - 4
SP  - 452-462
EP  - 452-462
PB  - WILEY-BLACKWELL
SN  - 10512284
KW  - Basal ganglia
KW  - Parkinson's disease
KW  - cerebellum
KW  - connectivity
KW  - cortical reorganization
KW  - motor timing
KW  - prediction
KW  - supplementary motor area
UR  - http://onlinelibrary.wiley.com/doi/10.1111/jon.12030/pdf
L2  - http://onlinelibrary.wiley.com/doi/10.1111/jon.12030/pdf
N2  - The cerebellum, basal ganglia (BG), and other cortical regions, such as supplementary motor area (SMA) have emerged as important structures dealing with various aspects of timing, yet the modulation of functional connectivity between them during motor timing tasks remains unexplored. METHODS: We used dynamic causal modeling to investigate the differences in effective connectivity (EC) between these regions and its modulation by behavioral outcome during a motor timing prediction task in a group of 16 patients with early Parkinson's disease (PD) and 17 healthy controls. Behavioral events (hits and errors) constituted the driving input connected to the cerebellum, and the modulation in connectivity was assessed relative to the hit condition (successful interception of target). RESULTS: The driving input elicited response in the target area, while modulatory input changed the specific connection strength. The neuroimaging data revealed similar structure of intrinsic connectivity in both groups with unidirectional connections from cerebellum to both sides of the BG, from BG to the SMA, and then from SMA to the cerebellum. However, the type of intrinsic connection was different between two groups. In the PD group, the connection between the SMA and cerebellum was inhibitory in comparison to the HC group, where the connection was activated. Furthermore, the modulation of connectivity by the performance in the task was different between the two groups, with decreased connectivity between the cerebellum and left BG and SMA and a more pronounced symmetry of these connections in controls. In the same time, there was an increased EC between the cerebellum and both sides of BG with more pronounced asymmetry (stronger connection with left BG) in patients. In addition, in the PD group the modulatory input strengthened inhibitory connectivity between the SMA and the cerebellum, while in the HC group the excitatory connection was slightly strengthened. CONCLUSIONS: Our findings indicate that although early PD subjects and controls use similar functional circuits to maintain a successful outcome in predictive motor timing behavior, the type and strength of EC and its modulation by behavioral performance differ between these two groups. These functional differences might represent the first step of cortical reorganization aimed at maintaining a normal performance in the brain affected by early Parkinson's disease and may have implications for the neuro-rehabilitation field.
ER  -

HUSÁROVÁ, Ivica, Michal MIKL, Ovidiu V. LUNGU, Radek MAREČEK, Jiří VANÍČEK and Martin BAREŠ. Similar circuits but different connectivity patterns between the cerebellum, Basal Ganglia, and supplementary motor area in early Parkinson's disease patients and controls during predictive motor timing. \textit{Journal of Neuroimaging}. Hoboken, USA: WILEY-BLACKWELL, 2013, vol.~23, No~4, p.~452-462. ISSN~1051-2284. Available from: https://dx.doi.org/10.1111/jon.12030.

Detailed Information on Publication Record