KOTASOVÁ, Hana, Jiřina PROCHÁZKOVÁ and Jiří PACHERNÍK. Interaction of Notch and gp130 Signaling in the Maintenance of Neural Stem and Progenitor Cells. Cellular and Molecular Neurobiology. NEW YORK: Springer Netherlands, 2014, vol. 34, No 1, p. 1-15. ISSN 0272-4340. Available from: https://dx.doi.org/10.1007/s10571-013-9996-6.
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Basic information
Original name Interaction of Notch and gp130 Signaling in the Maintenance of Neural Stem and Progenitor Cells
Authors KOTASOVÁ, Hana (203 Czech Republic, belonging to the institution), Jiřina PROCHÁZKOVÁ (203 Czech Republic, belonging to the institution) and Jiří PACHERNÍK (203 Czech Republic, guarantor, belonging to the institution).
Edition Cellular and Molecular Neurobiology, NEW YORK, Springer Netherlands, 2014, 0272-4340.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10601 Cell biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 2.506
RIV identification code RIV/00216224:14310/14:00074806
Organization unit Faculty of Science
Doi http://dx.doi.org/10.1007/s10571-013-9996-6
UT WoS 000330343100001
Keywords in English Neural stem cell; Neural progenitor; Signal transduction; Notch; gp130
Tags AKR
Tags International impact, Reviewed
Changed by Changed by: Mgr. Jiřina Medalová, Ph.D., učo 176525. Changed: 13/3/2018 11:12.
Abstract
Notch and gp130 signaling are involved in the regulation of multiple cellular processes across various tissues during animal ontogenesis. In the developing nervous system, both signaling pathways intervene at many stages to determine cell fate-from the first neural lineage commitment and generation of neuronal precursors, to the terminal specification of cells as neurons and glia. In most cases, the effects of Notch and gp130 signaling in these processes are similar. The aim of the current review was to summarize the knowledge regarding the roles of Notch and gp130 signaling in the maintenance of neural stem and progenitor cells during animal ontogenesis, from early embryo to adult. Recent data show a direct crosstalk between these signaling pathways that seems to be specific for a particular type of neural progenitors.
Links
MSM0021622430, plan (intention)Name: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie
Investor: Ministry of Education, Youth and Sports of the CR, Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
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