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@proceedings{1128405,
author = {Lánová, Martina and Večeřa, Josef and Kučera, Jan and Medalová, Jiřina and Pacherník, Jiří},
booktitle = {International Conference Analytical Cytometry VII Mikulov 2013},
keywords = {ABC-transporters neural stem cells},
language = {eng},
isbn = {978-80-905449-2-5},
title = {The role of ATP-binding transporters associated with multi-drug resistance in stem cells},
year = {2013}
}
TY - CONF
ID - 1128405
AU - Lánová, Martina - Večeřa, Josef - Kučera, Jan - Medalová, Jiřina - Pacherník, Jiří
PY - 2013
TI - The role of ATP-binding transporters associated with multi-drug resistance in stem cells
SN - 9788090544925
KW - ABC-transporters neural stem cells
N2 - ATP-binding transporters (ABC-t) play various roles in regulation organism function and homeostasis from prokaryota to mammals. ABC-t mediate transport of mainly lipophilic substances through cellular membranes. Some ABC-t are important in cell protection against endogenous and importantly also exogenous toxins. These transporters are called ABC-t associated with multi-drug resistance (ABC-t/MDR), according to their role in resistance of tumor cells to pharmacotherapy. ABC-t/MDR are also over-expressed in stem cells, where their protective role is expected, too. Particularly, ABCB1, ABCC1, and ABCG2 are common ABC-t/MDR expressed in stem cells. However, substrates of ABC-t/MDR are not only toxins, but also important signaling molecules as well leukotrienes and/or glutathione conjugates and porphyrins, which mediated balance in intracellular oxidation-reduction processing. Thus we hypothesize the role of ABC-t/MDR also in regulation of stem cells fate. To test this hypothesis we analyzed effect of modulation of ABC-t/MDR activity in embryonic and neural stem cells. We observed that ABCC1 and ABCG2 are the most expressed ABC-t/MDR in our tested stem cells. Importantly, inhibition of these ABC-t/MDR leads to decreasing of stemness and induction of differentiation in both embryonic and neural stem cells. Analysis of mechanism of observed effect and identification of studying ABC-t/MDR substrates, which may be responsible for this effect, are in progression.
ER -
LÁNOVÁ, Martina, Josef VEČEŘA, Jan KUČERA, Jiřina MEDALOVÁ a Jiří PACHERNÍK. The role of ATP-binding transporters associated with multi-drug resistance in stem cells. In \textit{International Conference Analytical Cytometry VII Mikulov 2013}. 2013. ISBN~978-80-905449-2-5.
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