ŠÁNA, Jiří, Andrej BEŠŠE, Radek LAKOMÝ, Leoš KŘEN, Zdeňka KOSAŘOVÁ, Pavel FADRUS, Pavel ŠLAMPA, Martin SMRČKA, Rostislav VYZULA and Ondřej SLABÝ. Global expression analysis of microRNAs in paired initial and relapsed glioblastoma. In The 18th World Congress on Advances in Oncology and 16th International Symposium on Molecular Medicine, Hotel Creta Maris Resort, Greece. 2013. ISSN 1107-3756.
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Basic information
Original name Global expression analysis of microRNAs in paired initial and relapsed glioblastoma
Authors ŠÁNA, Jiří, Andrej BEŠŠE, Radek LAKOMÝ, Leoš KŘEN, Zdeňka KOSAŘOVÁ, Pavel FADRUS, Pavel ŠLAMPA, Martin SMRČKA, Rostislav VYZULA and Ondřej SLABÝ.
Edition The 18th World Congress on Advances in Oncology and 16th International Symposium on Molecular Medicine, Hotel Creta Maris Resort, Greece, 2013.
Other information
Original language English
Type of outcome Conference abstract
Field of Study 30200 3.2 Clinical medicine
Country of publisher Greece
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.880
Organization unit Central European Institute of Technology
ISSN 1107-3756
UT WoS 000324507400014
Keywords in English glioblastoma multiforme; miRNA; relapse
Tags International impact, Reviewed
Changed by Changed by: Mgr. Petra Vychytilová, Ph.D., učo 211789. Changed: 3/12/2013 11:33.
Abstract
Glioblastoma multiforme (GBM) is the most commonly occurring primary brain tumour. Despite modern therapeutic approaches based on a radical resection, concomitant chemoradiotherapy with temozolomide and adjuvant chemotherapy, the median of overall survival is around 15 months from diagnosis. This infaust prognosis is mainly caused by GBM resistance to the indicated therapy. Therefore, it is very important to find new biomarkers, which will predict a clinical outcome of GBM patients who have undergone therapy with themozolomide. Recent studies show, that miRNAs could play an important role in chemo- and radioresistance of many tumours including GBM.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
NT13514, research and development projectName: Analýza mikroRNA v glioblastomových kmenových buňkách: predikce léčebné odpovědi a identifikace nových terapeutických cílů u pacientů s glioblastomem
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