The aim of this study was to determine the dynamics of the indicators of running economy (VO2.BM- 1.min-1 and deltaVO2.BM-1.min-1) within 48 hours after the application of explosive strength intervention (ESI). Nine university students, recreational athletes (age 23.8 +- 1.56 years, height 178 +- 4.8 cm, weight 74.8 +- 2.91 kg) underwent ESI (6 explosive strength exercises, 3 sets, 8 reps, rest 90 sec, maximum intensity) aimed mainly at lower limbs. The testing of running economy (RE) was performed during four separate measurements (-48, 0, 24 and 48 h; 0 = test immediately after the intervention) at 8, 10, 12 km.h-1 (5 min intervals; the last 60 sec of each level were recorded). It was found that when compared with the pretest values (-48 h), the average deltaVO2.BM-1,min-1 at 8 km.h-1 changed by +3.8% immediately after the intervention (0), by +1.6% after 24 h, and by 0% after 48 h. At 10 km.h-1, the changes were 6.3 - 4.3 - 0.4%, and at 12 km.h-1 they were 5.2 - 4.3 - 1.5%. According to the available literature, it was realistic to expect a peak of O2 consumption during 48 h after the intervention, but this was not observed. The results show the greatest deterioration of RE immediately after the intervention, with a subsequent decline of O2 consumption to resting levels within 48 h.