Can markers of collagen turnover or other biomarkers contribute to the diagnostics of heart failure with normal left ventricular ejection fraction?

MELUZÍN, Jaroslav, Josef TOMANDL, Helena PODROUŽKOVÁ, Zdeňka GREGOROVÁ, Vladimír SOŠKA, Petr DOBŠÁK, Ladislav PECEN and Radka STEPANOVA. Can markers of collagen turnover or other biomarkers contribute to the diagnostics of heart failure with normal left ventricular ejection fraction? Biomedical Papers of the Faculty of Medicine and Dentistry of Palacký University, Olomouc, Czech Republic. Olomouc: Palacký University, 2013, vol. 157, No 4, p. 331-339. ISSN 1213-8118. Available from: https://dx.doi.org/10.5507/bp.2012.110.

Basic information

• Original name: Can markers of collagen turnover or other biomarkers contribute to the diagnostics of heart failure with normal left ventricular ejection fraction?
• Authors: MELUZÍN, Jaroslav (203 Czech Republic, guarantor, belonging to the institution), Josef TOMANDL (203 Czech Republic, belonging to the institution), Helena PODROUŽKOVÁ (203 Czech Republic, belonging to the institution), Zdeňka GREGOROVÁ (203 Czech Republic, belonging to the institution), Vladimír SOŠKA (203 Czech Republic, belonging to the institution), Petr DOBŠÁK (203 Czech Republic, belonging to the institution), Ladislav PECEN (203 Czech Republic) and Radka STEPANOVA (203 Czech Republic).
• Edition: Biomedical Papers of the Faculty of Medicine and Dentistry of Palacký University, Olomouc, Czech Republic, Olomouc, Palacký University, 2013, 1213-8118.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30201 Cardiac and Cardiovascular systems
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 1.661
• RIV identification code: RIV/00216224:14110/13:00070610
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.5507/bp.2012.110
• UT WoS: 000329091500011
• Keywords in English: echocardiography; heart failure with normal ejection fraction; biomarkers
• Tags: International impact, Reviewed

Abstract

Aims. Plasma levels of some biomarkers and markers of collagen turnover may reflect myocardial structural abnormalities associated with diastolic dysfunction. The aim of this study was to determine whether these markers could contribute to the diagnostics of heart failure with normal ejection fraction (HFNEF). Methods and Results. 91 patients with exertional dyspnea and normal left ventricular ejection fraction and 20 healthy controls underwent plasma analysis of markers of collagen turnover and other biomarkers, spirometry, and resting and exercise echocardiography. 38 patients with dyspnea had evidence of HFNEF, diagnosed at the early stage. Compared to the remaining patients, those with HFNEF had a significantly higher plasma levels of carboxy-terminal telopeptide of collagen type I (median 4.5 ug/L vs. 3.5 ug/L, P<0.05) and big endothelin (median 1.1 pmol/L vs 0.9 pmol/L, P<0.05). Univariate logistic regression analysis revealed a significant association between HFNEF and the following biomarkers: big endothelin, amino-terminal propeptide of type III procollagen (PIIINP), and matrix metalloproteinase-2 (MMP-2). However, none of these biomarkers independently contributed to the HFNEF diagnostics in a multivariate logistic regression analysis. Conclusion Plasma levels of big endothelin, PIIINP, and MMP-2 were found to be associated with the presence of early diagnosed HFNEF. However, none of these biomarkers contributed independently to current noninvasive HFNEF diagnostics recommended by the European Society of Cardiology guidelines.