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@article{1137573,
author = {Raudenská, Martina and Gumulec, Jaromír and Babula, Petr and Stračina, Tibor and Sztalmachová, Markéta and Polanská, Hana and Adam, Vojtech and Kizek, Rene and Nováková, Marie and Masařík, Michal},
article_location = {SHARJAH},
article_number = {14},
doi = {http://dx.doi.org/10.2174/13895575113136660100},
keywords = {Arrhytmia; cardiotoxicity; dopamine; haloperidol; oxidative stress; Torsade de Pointes},
language = {eng},
issn = {1389-5575},
journal = {MINI-REVIEWS IN MEDICINAL CHEMISTRY},
title = {Haloperidol Cytotoxicity and Its Relation to Oxidative Stress},
volume = {13},
year = {2013}
}
TY - JOUR
ID - 1137573
AU - Raudenská, Martina - Gumulec, Jaromír - Babula, Petr - Stračina, Tibor - Sztalmachová, Markéta - Polanská, Hana - Adam, Vojtech - Kizek, Rene - Nováková, Marie - Masařík, Michal
PY - 2013
TI - Haloperidol Cytotoxicity and Its Relation to Oxidative Stress
JF - MINI-REVIEWS IN MEDICINAL CHEMISTRY
VL - 13
IS - 14
SP - 1993-1998
EP - 1993-1998
PB - BENTHAM SCIENCE PUBL LTD
SN - 13895575
KW - Arrhytmia
KW - cardiotoxicity
KW - dopamine
KW - haloperidol
KW - oxidative stress
KW - Torsade de Pointes
N2 - Haloperidol (HP) is used for the symptomatic treatment of psychosis, manic phases, hyperactivity, aggressiveness, and acute delirium. Long-term use leads to various adverse side effects, especially to severe impairment of extrapyramidal nerve tracts and in particular, altered QT interval and increased incidence of arrhytmias. It is believed that cytotoxicity of HP and its metabolites is responsible for both neurotoxicity and cardiotoxicity. Extrapyramidal and cardiac adverse side effects may be explained by the HP-induced oxidative stress, as implicated by many studies. HP was reported to induce lipid peroxidation with subsequent membrane changes, responsible for cell death. Vice versa, cells resistant to oxidative stress are also resistant to the toxic effects of HP. Similarly, high percentage of patients suffering from extrapyramidal symptoms treated by vitamin E and other lipid-soluble antioxidants demonstrates diminishing of these adverse side effects. HP’s ability to induce oxidative stress by multi-modal action (increased metabolism of dopamine, decrease of glutathione content, induction of NF-B transcription factor, and inhibition of complex I of respiratory chain) has been established just recently. This review brings summarizing view on the cytotoxicity of haloperidol and involvement of reactive oxygen species and oxidative stress HP-induced cytotoxicity.
ER -
RAUDENSKÁ, Martina, Jaromír GUMULEC, Petr BABULA, Tibor STRAČINA, Markéta SZTALMACHOVÁ, Hana POLANSKÁ, Vojtech ADAM, Rene KIZEK, Marie NOVÁKOVÁ and Michal MASAŘÍK. Haloperidol Cytotoxicity and Its Relation to Oxidative Stress. \textit{MINI-REVIEWS IN MEDICINAL CHEMISTRY}. SHARJAH: BENTHAM SCIENCE PUBL LTD, 2013, vol.~13, No~14, p.~1993-1998. ISSN~1389-5575. Available from: https://dx.doi.org/10.2174/13895575113136660100.
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