| KOPRIVA, Frantisek, Marek GODAVA, Marie MARKOVA, Radek VODICKA, Ladislav DUŠEK, Jan MUŽÍK, Eva SCHNEIDEROVA, Radek VRTEL a Vladimir MIHAL. Possible control of paternal imprinting of polymorphisms of the ADAM33 gene by epigenetic mechanisms and association with level of airway hyperresponsiveness in asthmatic children. Online. Biomedical Papers of the Faculty of Medicine and Dentistry of Palacký University, Olomouc, Czech Republic. Olomouc: Palacký University, 2013, roč. 157, č. 4, s. 367-373. ISSN 1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2013.025. [citováno 2024-04-23] |
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@article{1138438,
author = {Kopriva, Frantisek and Godava, Marek and Markova, Marie and Vodicka, Radek and Dušek, Ladislav and Mužík, Jan and Schneiderova, Eva and Vrtel, Radek and Mihal, Vladimir},
article_location = {Olomouc},
article_number = {4},
doi = {http://dx.doi.org/10.5507/bp.2013.025},
keywords = {ADAM33; Bronchial asthma; Bronchial hyperresponsiveness; Paternal haplotypes},
language = {eng},
issn = {1213-8118},
journal = {Biomedical Papers of the Faculty of Medicine and Dentistry of Palacký University, Olomouc, Czech Republic},
title = {Possible control of paternal imprinting of polymorphisms of the ADAM33 gene by epigenetic mechanisms and association with level of airway hyperresponsiveness in asthmatic children},
volume = {157},
year = {2013}
}
TY - JOUR
ID - 1138438
AU - Kopriva, Frantisek - Godava, Marek - Markova, Marie - Vodicka, Radek - Dušek, Ladislav - Mužík, Jan - Schneiderova, Eva - Vrtel, Radek - Mihal, Vladimir
PY - 2013
TI - Possible control of paternal imprinting of polymorphisms of the ADAM33 gene by epigenetic mechanisms and association with level of airway hyperresponsiveness in asthmatic children
JF - Biomedical Papers of the Faculty of Medicine and Dentistry of Palacký University, Olomouc, Czech Republic
VL - 157
IS - 4
SP - 367-373
EP - 367-373
PB - Palacký University
SN - 12138118
KW - ADAM33
KW - Bronchial asthma
KW - Bronchial hyperresponsiveness
KW - Paternal haplotypes
N2 - Introduction. ADAM33 is the candidate gene most commonly associated with asthma and airway hyperreactivity (AHR). Aim. The aim of this study was to determine whether level of AHR is associated with certain alleles or haplotypes of the ADAM33 gene in asthmatic children. Methods. One hundred and nine asthmatic children and 46 controls from the general population were examined with spirometry before and after histamine and methacholine inhalation. All subjects were genotyped for single-nucleotide polymorphisms (SNPs) of the ADAM33 gene. Haplotypes were determined according to genotypes of the patient's parents. Results. We found the three most frequent ADAM33 haplotypes (a1-3) were associated with the highest level of AHR to methacholine and histamine in 66% of asthmatic children. The paternally transmitted GGGCTTTCGCA haplotype was seen in 73.3% asthmatic children with serious AHR to methacholine challenge (paternal and maternal origin of haplotype 73.3% to 37.5, P=0.046) Significant differences in the relative frequency of paternal haplotypes with high levels of AHR to histamine were found (P=0.013). Conclusion. ADAM33 haplotypes (a1, a2, a3) are associated with severity of AHR and are significantly more often transmitted in the paternal line.
ER -
KOPRIVA, Frantisek, Marek GODAVA, Marie MARKOVA, Radek VODICKA, Ladislav DUŠEK, Jan MUŽÍK, Eva SCHNEIDEROVA, Radek VRTEL a Vladimir MIHAL. Possible control of paternal imprinting of polymorphisms of the ADAM33 gene by epigenetic mechanisms and association with level of airway hyperresponsiveness in asthmatic children. Online. \textit{Biomedical Papers of the Faculty of Medicine and Dentistry of Palacký University, Olomouc, Czech Republic}. Olomouc: Palacký University, 2013, roč.~157, č.~4, s.~367-373. ISSN~1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2013.025. [citováno 2024-04-23]
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