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@article{1138939,
author = {Gora, Artur Wiktor and Brezovský, Jan and Damborský, Jiří},
article_number = {8},
doi = {http://dx.doi.org/10.1021/cr300384w},
keywords = {haloalkane dehalogenases},
language = {eng},
issn = {0009-2665},
journal = {Chemical Reviews},
title = {Gates of Enzymes.},
volume = {113},
year = {2013}
}
TY - JOUR
ID - 1138939
AU - Gora, Artur Wiktor - Brezovský, Jan - Damborský, Jiří
PY - 2013
TI - Gates of Enzymes.
JF - Chemical Reviews
VL - 113
IS - 8
SP - 5871-5923
EP - 5871-5923
SN - 00092665
KW - haloalkane dehalogenases
N2 - This review highlights the importance of gates in enzymes. The gates control substrate access to the active site and product release, restrict solvent access to specific protein regions, and synchronize processes occurring in distinct parts of the enzyme. Survey of 129 gates in 71 enzymes enabled a rigorous definition of gates and establishment of a new scheme for their classification. Gates were assigned to six distinct classes – wings, swinging doors, apertures, drawbridges, double drawbridges and shells. Presented are summary statistics describing the propensity of specific amino acid residues in particular gate classes. The proposed classification scheme provides guidance for the analysis and engineering of gates in biomolecular systems.
ER -
GORA, Artur Wiktor, Jan BREZOVSKÝ and Jiří DAMBORSKÝ. Gates of Enzymes. \textit{Chemical Reviews}. 2013, vol.~113, No~8, p.~5871-5923. ISSN~0009-2665. Available from: https://dx.doi.org/10.1021/cr300384w.
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