Molecular mechanisms of neuropathological changes in
Alzheimer`s disease: a review

J 2013

Molecular mechanisms of neuropathological changes in Alzheimer`s disease: a review

ŠERÝ, Omar, Jana POVOVÁ, Ivan MÍŠEK, Lukáš PEŠÁK, Vladimír JANOUT et. al.

Basic information

Original name

Molecular mechanisms of neuropathological changes in Alzheimer`s disease: a review

Authors

ŠERÝ, Omar (203 Czech Republic, guarantor, belonging to the institution), Jana POVOVÁ (203 Czech Republic), Ivan MÍŠEK (203 Czech Republic), Lukáš PEŠÁK (203 Czech Republic) and Vladimír JANOUT (203 Czech Republic)

Edition

Folia Neuropathologica, 2013, 1641-4640

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Poland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.667

RIV identification code

RIV/00216224:14310/13:00065652

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.5114/fn.2013.34190

UT WoS

000317316400001

Keywords in English

Alzheimer`s disease; amyloid precursor protein; tau protein; apolipoprotein E

Abstract

V originále

More than 100 years after description of Alzheimer's disease (AD), two major pathological processes observed already by Alois Alzheimer, remain as the main explanation of the pathogenesis of Alzheimer's disease. Important molecular interactions leading to AD neuropathology were described in amyloid cascade and in tau protein function. No clinical trials with novel therapies based on amyloid cascade and tau protein hypotheses have been successful. The main aim of recent research is focused on the question what is primary mechanism leading to the molecular development of AD pathology. Promising explanation of triggering mechanism can be seen in vascular pathology that have direct influence on the development of pathological processes typical for Alzheimer disease. Novel insight into a number of cellular signaling mechanisms, as well as mitochondrial function in Alzheimer disease could also bring explanations of initial processes leading to the development of this pathology.

Links

NT11152, research and development project

Name: Epidemiologie a genetika Alzheimerovy choroby

Citovat

ŠERÝ, Omar, Jana POVOVÁ, Ivan MÍŠEK, Lukáš PEŠÁK and Vladimír JANOUT. Molecular mechanisms of neuropathological changes in Alzheimer`s disease: a review. Folia Neuropathologica. 2013, vol. 51, No 1, p. 1-9. ISSN 1641-4640. Available from: https://dx.doi.org/10.5114/fn.2013.34190.

@article{1139036,
   author = {Šerý, Omar and Povová, Jana and Míšek, Ivan and Pešák, Lukáš and Janout, Vladimír},
   article_number = {1},
   doi = {http://dx.doi.org/10.5114/fn.2013.34190},
   keywords = {Alzheimer`s disease; amyloid precursor protein; tau protein; apolipoprotein E},
   language = {eng},
   issn = {1641-4640},
   journal = {Folia Neuropathologica},
   title = {Molecular mechanisms of neuropathological changes in Alzheimer`s disease: a review},
   volume = {51},
   year = {2013}
}

TY  - JOUR
ID  - 1139036
AU  - Šerý, Omar - Povová, Jana - Míšek, Ivan - Pešák, Lukáš - Janout, Vladimír
PY  - 2013
TI  - Molecular mechanisms of neuropathological changes in Alzheimer`s disease: a review
JF  - Folia Neuropathologica
VL  - 51
IS  - 1
SP  - 1-9
EP  - 1-9
SN  - 16414640
KW  - Alzheimer`s disease
KW  - amyloid precursor protein
KW  - tau protein
KW  - apolipoprotein E
N2  - More than 100 years after description of Alzheimer's disease (AD), two major pathological processes observed already by Alois Alzheimer, remain as the main explanation of the pathogenesis of Alzheimer's disease. Important molecular interactions leading to AD neuropathology were described in amyloid cascade and in tau protein function. No clinical trials with novel therapies based on amyloid cascade and tau protein hypotheses have been successful. The main aim of recent research is focused on the question what is primary mechanism leading to the molecular development of AD pathology. Promising explanation of triggering mechanism can be seen in vascular pathology that have direct influence on the development of pathological processes typical for Alzheimer disease. Novel insight into a number of cellular signaling mechanisms, as well as mitochondrial function in Alzheimer disease could also bring explanations of initial processes leading to the development of this pathology.
ER  -

ŠERÝ, Omar, Jana POVOVÁ, Ivan MÍŠEK, Lukáš PEŠÁK and Vladimír JANOUT. Molecular mechanisms of neuropathological changes in Alzheimer`s disease: a review. \textit{Folia Neuropathologica}. 2013, vol.~51, No~1, p.~1-9. ISSN~1641-4640. Available from: https://dx.doi.org/10.5114/fn.2013.34190.

Detailed Information on Publication Record