Advances in the Diagnosis of Endemic Treponematoses: Yaws,
Bejel, and Pinta

J 2013

Advances in the Diagnosis of Endemic Treponematoses: Yaws, Bejel, and Pinta

MITJÀ, Oriol, David ŠMAJS and Quique BASSAT

Basic information

Original name

Advances in the Diagnosis of Endemic Treponematoses: Yaws, Bejel, and Pinta

Authors

MITJÀ, Oriol (598 Papua New Guinea), David ŠMAJS (203 Czech Republic, guarantor, belonging to the institution) and Quique BASSAT (724 Spain)

Edition

PLoS Neglected Tropical Diseases, San Francisco, Public Library of Science, 2013, 1935-2735

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 4.489

RIV identification code

RIV/00216224:14110/13:00070883

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1371/journal.pntd.0002283

UT WoS

000330376500001

Keywords in English

endemic treponematoses; treponema; bejel; yaws; pinta

Abstract

V originále

Improved understanding of the differential diagnosis of endemic treponematoses is needed to inform clinical practice and to ensure the best outcome for a new global initiative for the eradication of yaws, bejel, and pinta. Traditionally, the human treponematoses have been differentiated based upon their clinical manifestations and epidemiologic characteristics because the etiologic agents are indistinguishable in the laboratory. Serological tests are still considered standard laboratory methods for the diagnosis of endemic treponematoses and new rapid point-of-care treponemal tests have become available which are extremely useful in low-resource settings. In the past ten years, there has been an increasing effort to apply polymerase chain reaction to treponematoses and whole genome fingerprinting techniques have identified genetic signatures that can differentiate the existing treponemal strains; however, definitive diagnosis is also hampered by widespread unavailability of molecular diagnostics. We review the dilemmas in the diagnosis of endemic treponematoses, and advances in the discovery of new diagnostic tools.

Citovat

MITJÀ, Oriol, David ŠMAJS and Quique BASSAT. Advances in the Diagnosis of Endemic Treponematoses: Yaws, Bejel, and Pinta. PLoS Neglected Tropical Diseases. San Francisco: Public Library of Science, 2013, vol. 7, No 10, p. e2283, 9 pp. ISSN 1935-2735. Available from: https://dx.doi.org/10.1371/journal.pntd.0002283.

@article{1139225,
   author = {Mitjà, Oriol and Šmajs, David and Bassat, Quique},
   article_location = {San Francisco},
   article_number = {10},
   doi = {http://dx.doi.org/10.1371/journal.pntd.0002283},
   keywords = {endemic treponematoses; treponema; bejel; yaws; pinta},
   language = {eng},
   issn = {1935-2735},
   journal = {PLoS Neglected Tropical Diseases},
   title = {Advances in the Diagnosis of Endemic Treponematoses: Yaws, Bejel, and Pinta},
   volume = {7},
   year = {2013}
}

TY  - JOUR
ID  - 1139225
AU  - Mitjà, Oriol - Šmajs, David - Bassat, Quique
PY  - 2013
TI  - Advances in the Diagnosis of Endemic Treponematoses: Yaws, Bejel, and Pinta
JF  - PLoS Neglected Tropical Diseases
VL  - 7
IS  - 10
SP  - e2283
EP  - e2283
PB  - Public Library of Science
SN  - 19352735
KW  - endemic treponematoses
KW  - treponema
KW  - bejel
KW  - yaws
KW  - pinta
N2  - Improved understanding of the differential diagnosis of endemic treponematoses is needed to inform clinical practice and to ensure the best outcome for a new global initiative for the eradication of yaws, bejel, and pinta. Traditionally, the human treponematoses have been differentiated based upon their clinical manifestations and epidemiologic characteristics because the etiologic agents are indistinguishable in the laboratory. Serological tests are still considered standard laboratory methods for the diagnosis of endemic treponematoses and new rapid point-of-care treponemal tests have become available which are extremely useful in low-resource settings. In the past ten years, there has been an increasing effort to apply polymerase chain reaction to treponematoses and whole genome fingerprinting techniques have identified genetic signatures that can differentiate the existing treponemal strains; however, definitive diagnosis is also hampered by widespread unavailability of molecular diagnostics. We review the dilemmas in the diagnosis of endemic treponematoses, and advances in the discovery of new diagnostic tools.
ER  -

MITJÀ, Oriol, David ŠMAJS and Quique BASSAT. Advances in the Diagnosis of Endemic Treponematoses: Yaws, Bejel, and Pinta. \textit{PLoS Neglected Tropical Diseases}. San Francisco: Public Library of Science, 2013, vol.~7, No~10, p.~e2283, 9 pp. ISSN~1935-2735. Available from: https://dx.doi.org/10.1371/journal.pntd.0002283.

Detailed Information on Publication Record