| ŠÁLEK, David, Pavla VESELÁ, Ludmila BOUDOVÁ, Andrea JANÍKOVÁ, Pavel KLENER, Samuel VOKURKA, Milada JANKOVSKA, Robert PYTLIK, David BELADA, Jan PIRNOS, Mojmír MOULIS, Roman KODET, Michal MICHAL, Eva JANOUŠOVÁ, Jan MUŽÍK, Jiří MAYER and Marek TRNĚNÝ. Retrospective analysis of 235 unselected patients with mantle cell lymphoma confirms prognostic relevance of Mantle Cell Lymphoma International Prognostic Index and Ki-67 in the era of rituximab: long-term data from the Czech Lymphoma Project Database. Leukemia & lymphoma. London: Informa Healthcare, 2014, vol. 55, No 4, p. 802-810. ISSN 1042-8194. Available from: https://dx.doi.org/10.3109/10428194.2013.815349. |
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@article{1139282,
author = {Šálek, David and Veselá, Pavla and Boudová, Ludmila and Janíková, Andrea and Klener, Pavel and Vokurka, Samuel and Jankovska, Milada and Pytlik, Robert and Belada, David and Pirnos, Jan and Moulis, Mojmír and Kodet, Roman and Michal, Michal and Janoušová, Eva and Mužík, Jan and Mayer, Jiří and Trněný, Marek},
article_location = {London},
article_number = {4},
doi = {http://dx.doi.org/10.3109/10428194.2013.815349},
keywords = {Mantle cell lymphoma; MIPI; Ki-67; proliferation; immunochemotherapy; prognosis},
language = {eng},
issn = {1042-8194},
journal = {Leukemia & lymphoma},
title = {Retrospective analysis of 235 unselected patients with mantle cell lymphoma confirms prognostic relevance of Mantle Cell Lymphoma International Prognostic Index and Ki-67 in the era of rituximab: long-term data from the Czech Lymphoma Project Database},
volume = {55},
year = {2014}
}
TY - JOUR
ID - 1139282
AU - Šálek, David - Veselá, Pavla - Boudová, Ludmila - Janíková, Andrea - Klener, Pavel - Vokurka, Samuel - Jankovska, Milada - Pytlik, Robert - Belada, David - Pirnos, Jan - Moulis, Mojmír - Kodet, Roman - Michal, Michal - Janoušová, Eva - Mužík, Jan - Mayer, Jiří - Trněný, Marek
PY - 2014
TI - Retrospective analysis of 235 unselected patients with mantle cell lymphoma confirms prognostic relevance of Mantle Cell Lymphoma International Prognostic Index and Ki-67 in the era of rituximab: long-term data from the Czech Lymphoma Project Database
JF - Leukemia & lymphoma
VL - 55
IS - 4
SP - 802-810
EP - 802-810
PB - Informa Healthcare
SN - 10428194
KW - Mantle cell lymphoma
KW - MIPI
KW - Ki-67
KW - proliferation
KW - immunochemotherapy
KW - prognosis
N2 - Although a prognostic model (MIPI, Mantle Cell Lymphoma International Prognostic Index) for patients with mantle cell lymphoma (MCL) has been established, its clinical significance for daily practice in the rituximab era remains controversial. Data of 235 unselected patients with MCL from the Czech Lymphoma Project Database were analyzed. MIPI, simplified MIPI (s-MIPI) and Ki-67 proliferation index were assessed for all patients and for a subgroup of 155 rituximab-treated (RT) patients. MIPI divided all patients into subgroups of low-risk (22%), intermediate-risk (29%) and high-risk (49%), with median overall survival 105.8 vs. 54.1 vs. 24.6 months, respectively (p < 0.001). s-MIPI revealed similar results. The validity of both indexes was confirmed in RT patients. We confirmed the Ki-67 index to be a powerful single prognostic factor for overall survival (64.4 vs. 20.1 months, p < 0.001) for all patients and for the RT subset. Our results confirm the clinical relevance of MIPI, s-MIPI and Ki-67 for risk stratification in MCL also in the rituximab era.
ER -
ŠÁLEK, David, Pavla VESELÁ, Ludmila BOUDOVÁ, Andrea JANÍKOVÁ, Pavel KLENER, Samuel VOKURKA, Milada JANKOVSKA, Robert PYTLIK, David BELADA, Jan PIRNOS, Mojmír MOULIS, Roman KODET, Michal MICHAL, Eva JANOUŠOVÁ, Jan MUŽÍK, Jiří MAYER and Marek TRNĚNÝ. Retrospective analysis of 235 unselected patients with mantle cell lymphoma confirms prognostic relevance of Mantle Cell Lymphoma International Prognostic Index and Ki-67 in the era of rituximab: long-term data from the Czech Lymphoma Project Database. \textit{Leukemia \&{} lymphoma}. London: Informa Healthcare, 2014, vol.~55, No~4, p.~802-810. ISSN~1042-8194. Available from: https://dx.doi.org/10.3109/10428194.2013.815349.
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