Unique Activity Spectrum of Colicin FY: All 110 Characterized
Yersinia enterocolitica Isolates Were Colicin FY Susceptible

J 2013

Unique Activity Spectrum of Colicin FY: All 110 Characterized Yersinia enterocolitica Isolates Were Colicin FY Susceptible

BOSÁK, Juraj, Lenka MICENKOVÁ, Martin VRBA, Alena ŠEVČÍKOVÁ, Daniela DĚDIČOVÁ et. al.

Basic information

Original name

Unique Activity Spectrum of Colicin FY: All 110 Characterized Yersinia enterocolitica Isolates Were Colicin FY Susceptible

Authors

BOSÁK, Juraj (703 Slovakia, belonging to the institution), Lenka MICENKOVÁ (703 Slovakia, belonging to the institution), Martin VRBA (203 Czech Republic), Alena ŠEVČÍKOVÁ (203 Czech Republic), Daniela DĚDIČOVÁ (203 Czech Republic), Debora GARZETTI (276 Germany) and David ŠMAJS (203 Czech Republic, guarantor, belonging to the institution)

Edition

Plos One, PUBLIC LIBRARY SCIENCE, SAN FRANCISCO, 2013, 1932-6203

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.534

RIV identification code

RIV/00216224:14110/13:00065661

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1371/journal.pone.0081829

UT WoS

000328707400047

Keywords in English

Colicin FY; Yersinia enterocolitica

Abstract

V originále

Colicin FY is a plasmid encoded toxin that recognizes a yersinia-specific outer membrane protein (YiuR) as a receptor molecule. We have previously shown that the activity spectrum of colicin FY comprises strains of the genus Yersinia. In this study, we analyzed the activity of colicin FY against 110 Yersinia enterocolitica isolates differing in geographical origin and source. All isolates were characterized through analysis of 16S rRNA genes, serotyping, biotyping, restriction profiling of genomic DNA, detection of virulence markers and susceptibility to antibiotics. This confirmed the broad variability of the collection, in which all 110 Y. enterocolitica isolates, representing 77 various strains, were inhibited by colicin FY. Although isolates showed variable levels of susceptibility to colicin FY, it was not associated with any strain characteristic. The universal susceptibility of Y. enterocolitica strains to colicin FY together with the absence of activity towards strains outside the Yersinia genus suggests potential therapeutic applications for colicin FY.

Links

NT13413, research and development project

Name: Stanovení apoptózy v biopticky odebraných vzorcích z tlustého střeva

Investor: Ministry of Health of the CR

Citovat

BOSÁK, Juraj, Lenka MICENKOVÁ, Martin VRBA, Alena ŠEVČÍKOVÁ, Daniela DĚDIČOVÁ, Debora GARZETTI and David ŠMAJS. Unique Activity Spectrum of Colicin FY: All 110 Characterized Yersinia enterocolitica Isolates Were Colicin FY Susceptible. Plos One. PUBLIC LIBRARY SCIENCE: SAN FRANCISCO, 2013, vol. 8, No 12, p. e81829, 7 pp. ISSN 1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0081829.

@article{1159229,
   author = {Bosák, Juraj and Micenková, Lenka and Vrba, Martin and Ševčíková, Alena and Dědičová, Daniela and Garzetti, Debora and Šmajs, David},
   article_location = {PUBLIC LIBRARY SCIENCE},
   article_number = {12},
   doi = {http://dx.doi.org/10.1371/journal.pone.0081829},
   keywords = {Colicin FY; Yersinia enterocolitica},
   language = {eng},
   issn = {1932-6203},
   journal = {Plos One},
   title = {Unique Activity Spectrum of Colicin FY: All 110 Characterized Yersinia enterocolitica Isolates Were Colicin FY Susceptible},
   volume = {8},
   year = {2013}
}

TY  - JOUR
ID  - 1159229
AU  - Bosák, Juraj - Micenková, Lenka - Vrba, Martin - Ševčíková, Alena - Dědičová, Daniela - Garzetti, Debora - Šmajs, David
PY  - 2013
TI  - Unique Activity Spectrum of Colicin FY: All 110 Characterized Yersinia enterocolitica Isolates Were Colicin FY Susceptible
JF  - Plos One
VL  - 8
IS  - 12
SP  - e81829
EP  - e81829
PB  - SAN FRANCISCO
SN  - 19326203
KW  - Colicin FY
KW  - Yersinia enterocolitica
N2  - Colicin FY is a plasmid encoded toxin that recognizes a yersinia-specific outer membrane protein (YiuR) as a receptor molecule. We have previously shown that the activity spectrum of colicin FY comprises strains of the genus Yersinia. In this study, we analyzed the activity of colicin FY against 110 Yersinia enterocolitica isolates differing in geographical origin and source. All isolates were characterized through analysis of 16S rRNA genes, serotyping, biotyping, restriction profiling of genomic DNA, detection of virulence markers and susceptibility to antibiotics. This confirmed the broad variability of the collection, in which all 110 Y. enterocolitica isolates, representing 77 various strains, were inhibited by colicin FY. Although isolates showed variable levels of susceptibility to colicin FY, it was not associated with any strain characteristic. The universal susceptibility of Y. enterocolitica strains to colicin FY together with the absence of activity towards strains outside the Yersinia genus suggests potential therapeutic applications for colicin FY.
ER  -

BOSÁK, Juraj, Lenka MICENKOVÁ, Martin VRBA, Alena ŠEVČÍKOVÁ, Daniela DĚDIČOVÁ, Debora GARZETTI and David ŠMAJS. Unique Activity Spectrum of Colicin FY: All 110 Characterized Yersinia enterocolitica Isolates Were Colicin FY Susceptible. \textit{Plos One}. PUBLIC LIBRARY SCIENCE: SAN FRANCISCO, 2013, vol.~8, No~12, p.~e81829, 7 pp. ISSN~1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0081829.

Detailed Information on Publication Record