Association of Surface Contamination by Antineoplastic Drugs
With Different Working Conditions in Hospital Pharmacies

J 2014

Association of Surface Contamination by Antineoplastic Drugs With Different Working Conditions in Hospital Pharmacies

ODRÁŠKA, Pavel, Lenka DOLEZALOVA, Jan KUTA, Michal ORAVEC, Pavel PILER et. al.

Basic information

Original name

Association of Surface Contamination by Antineoplastic Drugs With Different Working Conditions in Hospital Pharmacies

Authors

ODRÁŠKA, Pavel (203 Czech Republic, guarantor, belonging to the institution), Lenka DOLEZALOVA (203 Czech Republic), Jan KUTA (203 Czech Republic, belonging to the institution), Michal ORAVEC (203 Czech Republic, belonging to the institution), Pavel PILER (203 Czech Republic, belonging to the institution), Stanislav SYNEK (203 Czech Republic) and Luděk BLÁHA (203 Czech Republic, belonging to the institution)

Edition

ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH, ABINGDON, ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2014, 1933-8244

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30304 Public and environmental health

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 0.932

RIV identification code

RIV/00216224:14310/14:00074907

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1080/19338244.2013.763757

UT WoS

000328103500005

Keywords in English

antineoplastic agents; carcinogens; chemical exposure; cytotoxic drugs; exposure assessment; surface contamination

Abstract

V originále

This study investigates the surface contamination levels of cyclophosphamide and platinum (a marker of platinum-containing drugs) in storage and preparation areas of hospital pharmacies and their relationship to working conditions surveyed by questionnaire. In total, 259 wipe samples were collected in 13 hospital pharmacies over 4 sampling campaigns. After sample extraction with acetate buffer, cyclophosphamide and platinum were determined using high-performance liquid chromatography-tandem mass spectroscopy (HPLC-MS/MS) and inductively coupled plasma mass spectrometry (ICP-MS). Depending on the sampling spot and campaign, median concentrations ranged from <2 to 61 pg/cm(2) and from <0.2 to 6.9 pg/cm(2) for cyclophosphamide and platinum, respectively. Statistical evaluation of monitoring data revealed that the contamination level was significantly influenced by laboratory throughput (expressed as number of chemotherapies prepared per week), personnel expertise (ie, participation of pharmacists with academic education in drug admixture activities), and surface material.

Links

ED0001/01/01, research and development project

Name: CETOCOEN

Citovat

ODRÁŠKA, Pavel, Lenka DOLEZALOVA, Jan KUTA, Michal ORAVEC, Pavel PILER, Stanislav SYNEK and Luděk BLÁHA. Association of Surface Contamination by Antineoplastic Drugs With Different Working Conditions in Hospital Pharmacies. ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH. ABINGDON: ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2014, vol. 69, No 3, p. 148-158. ISSN 1933-8244. Available from: https://dx.doi.org/10.1080/19338244.2013.763757.

@article{1159640,
   author = {Odráška, Pavel and Dolezalova, Lenka and Kuta, Jan and Oravec, Michal and Piler, Pavel and Synek, Stanislav and Bláha, Luděk},
   article_location = {ABINGDON},
   article_number = {3},
   doi = {http://dx.doi.org/10.1080/19338244.2013.763757},
   keywords = {antineoplastic agents; carcinogens; chemical exposure; cytotoxic drugs; exposure assessment; surface contamination},
   language = {eng},
   issn = {1933-8244},
   journal = {ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH},
   title = {Association of Surface Contamination by Antineoplastic Drugs With Different Working Conditions in Hospital Pharmacies},
   volume = {69},
   year = {2014}
}

TY  - JOUR
ID  - 1159640
AU  - Odráška, Pavel - Dolezalova, Lenka - Kuta, Jan - Oravec, Michal - Piler, Pavel - Synek, Stanislav - Bláha, Luděk
PY  - 2014
TI  - Association of Surface Contamination by Antineoplastic Drugs With Different Working Conditions in Hospital Pharmacies
JF  - ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
VL  - 69
IS  - 3
SP  - 148-158
EP  - 148-158
PB  - ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
SN  - 19338244
KW  - antineoplastic agents
KW  - carcinogens
KW  - chemical exposure
KW  - cytotoxic drugs
KW  - exposure assessment
KW  - surface contamination
N2  - This study investigates the surface contamination levels of cyclophosphamide and platinum (a marker of platinum-containing drugs) in storage and preparation areas of hospital pharmacies and their relationship to working conditions surveyed by questionnaire. In total, 259 wipe samples were collected in 13 hospital pharmacies over 4 sampling campaigns. After sample extraction with acetate buffer, cyclophosphamide and platinum were determined using high-performance liquid chromatography-tandem mass spectroscopy (HPLC-MS/MS) and inductively coupled plasma mass spectrometry (ICP-MS). Depending on the sampling spot and campaign, median concentrations ranged from <2 to 61 pg/cm(2) and from <0.2 to 6.9 pg/cm(2) for cyclophosphamide and platinum, respectively. Statistical evaluation of monitoring data revealed that the contamination level was significantly influenced by laboratory throughput (expressed as number of chemotherapies prepared per week), personnel expertise (ie, participation of pharmacists with academic education in drug admixture activities), and surface material.
ER  -

ODRÁŠKA, Pavel, Lenka DOLEZALOVA, Jan KUTA, Michal ORAVEC, Pavel PILER, Stanislav SYNEK and Luděk BLÁHA. Association of Surface Contamination by Antineoplastic Drugs With Different Working Conditions in Hospital Pharmacies. \textit{ARCHIVES OF ENVIRONMENTAL \&{}amp; OCCUPATIONAL HEALTH}. ABINGDON: ROUTLEDGE JOURNALS, TAYLOR \&{}amp; FRANCIS LTD, 2014, vol.~69, No~3, p.~148-158. ISSN~1933-8244. Available from: https://dx.doi.org/10.1080/19338244.2013.763757.

Detailed Information on Publication Record