| ODRÁŠKA, Pavel, Lenka DOLEZALOVA, Jan KUTA, Michal ORAVEC, Pavel PILER, Stanislav SYNEK and Luděk BLÁHA. Association of Surface Contamination by Antineoplastic Drugs With Different Working Conditions in Hospital Pharmacies. ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH. ABINGDON: ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2014, vol. 69, No 3, p. 148-158. ISSN 1933-8244. Available from: https://dx.doi.org/10.1080/19338244.2013.763757. |
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@article{1159640,
author = {Odráška, Pavel and Dolezalova, Lenka and Kuta, Jan and Oravec, Michal and Piler, Pavel and Synek, Stanislav and Bláha, Luděk},
article_location = {ABINGDON},
article_number = {3},
doi = {http://dx.doi.org/10.1080/19338244.2013.763757},
keywords = {antineoplastic agents; carcinogens; chemical exposure; cytotoxic drugs; exposure assessment; surface contamination},
language = {eng},
issn = {1933-8244},
journal = {ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH},
title = {Association of Surface Contamination by Antineoplastic Drugs With Different Working Conditions in Hospital Pharmacies},
volume = {69},
year = {2014}
}
TY - JOUR
ID - 1159640
AU - Odráška, Pavel - Dolezalova, Lenka - Kuta, Jan - Oravec, Michal - Piler, Pavel - Synek, Stanislav - Bláha, Luděk
PY - 2014
TI - Association of Surface Contamination by Antineoplastic Drugs With Different Working Conditions in Hospital Pharmacies
JF - ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
VL - 69
IS - 3
SP - 148-158
EP - 148-158
PB - ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
SN - 19338244
KW - antineoplastic agents
KW - carcinogens
KW - chemical exposure
KW - cytotoxic drugs
KW - exposure assessment
KW - surface contamination
N2 - This study investigates the surface contamination levels of cyclophosphamide and platinum (a marker of platinum-containing drugs) in storage and preparation areas of hospital pharmacies and their relationship to working conditions surveyed by questionnaire. In total, 259 wipe samples were collected in 13 hospital pharmacies over 4 sampling campaigns. After sample extraction with acetate buffer, cyclophosphamide and platinum were determined using high-performance liquid chromatography-tandem mass spectroscopy (HPLC-MS/MS) and inductively coupled plasma mass spectrometry (ICP-MS). Depending on the sampling spot and campaign, median concentrations ranged from <2 to 61 pg/cm(2) and from <0.2 to 6.9 pg/cm(2) for cyclophosphamide and platinum, respectively. Statistical evaluation of monitoring data revealed that the contamination level was significantly influenced by laboratory throughput (expressed as number of chemotherapies prepared per week), personnel expertise (ie, participation of pharmacists with academic education in drug admixture activities), and surface material.
ER -
ODRÁŠKA, Pavel, Lenka DOLEZALOVA, Jan KUTA, Michal ORAVEC, Pavel PILER, Stanislav SYNEK and Luděk BLÁHA. Association of Surface Contamination by Antineoplastic Drugs With Different Working Conditions in Hospital Pharmacies. \textit{ARCHIVES OF ENVIRONMENTAL \&{}amp; OCCUPATIONAL HEALTH}. ABINGDON: ROUTLEDGE JOURNALS, TAYLOR \&{}amp; FRANCIS LTD, 2014, vol.~69, No~3, p.~148-158. ISSN~1933-8244. Available from: https://dx.doi.org/10.1080/19338244.2013.763757.
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