Status Update and Interim Results from the Asymptomatic Carotid Surgery Trial-2 (ACST-2)

HALLIDAY, Alison, Richard BULBULIA, William GRAY, Ally NAUGHTEN, Anne den HARTOG, Antonella DELMESTRI, Carol WALLIS, Stephanie le CONTE, Sumaira MACDONALD, P. CRAS, J. M. H. HENDRIKS, P. LAUWERS, M. HERTOGHS, P Van SCHIL, L De JAEGHER, P. PEETERS, J. VERBIST, D. DENDOOVEN, J De LETTER, G. VANHOOREN, P. ASTARCI, I. CAPRON, C. CHOGHARI, F. HAMMER, V. LACROIX, A. PEETERS, R. VERHELST, M. BOSIERS, K De MEESTER, K. DELOOSE, E Van BUGGENHOUT, E. VINCK, M. GEENENS, D. HEMELSOET, I Van HERZEELE, F. VERMASSEN, G De KOSTER, Q. DESIRON, A de Noordhout MAERTENS, D. MALMENDIER, M. MASSOZ, G. SAAD, S. CIRELLI, P. DORMAL, P. LERUT, E. THUES, S. COUTTS, A. DEMCHUK, M. HILL, M. HUDON, G. KLEIN, M. MCCLELLAND, W. MORRISH, G. SAMIS, G. SUTHERLAND, T. WATSON, J. WONG, Bao LIU, Chang-Wei LIU, L. BARANKOVA, V. CHLOUBA, J. FIEDLER, V. PRIBAN, L. STERBA, L. KALABOVA, Z. KRIZ, P. KRUPA, M. PRIVARA, M. REIF, L. SOUCKOVA, Robert STAFFA, Robert VLACHOVSKÝ, B. VOJTISEK, T. HRBAC, M. KULIHA, V. PROCHAZKA, M. ROUBEC, D. SKOLOUDIK, F Abd ALLAH, M. H. ELDESSOKI, H Heshmat KASSEM, H Soliman GHARIEB, J. M. CARDON, A Le Gallou WITTENBERG, E. ALLAIRE, J. P. BECQUEMIN, F. COCHENNEC, P. DESGRANGES, H. HOSSEINI, H. KOBEITER, J. MARZELLE, P. BERGERON, R. PADOVANI, J. C. TRASTOUR, B. BIERMAIER, H. M. GISSLER, C. KLOTZSCH, T. PFEIFFER, R. SCHNEIDER, L. SOEHL, M. WENNRIH, Y. BAUSBACK, S. BOTSIOS, D. BRANZAN, S. BRAUNLICH, H. HOLZER, J. LENZER, C. REICHENBECHER, C. PIORKOWSKI, J. SCHUSTER, D. SCHEINERT, A. SCHMIDT, M. ULRICH, M. WERNER, A. COSTER, A. ENGELHARDT, C. M. RATUSINSKI, B. BEREKOVEN, K. FRERKER, V. GORDON, G. TORSELLO, I. BELLENIS, A. POLYDOROU, V. POLYDOROU, A. TAVERNARAKIS, N. IOANNOU, M. TERZOUDI, E. CHATZINIKOU, A. GIANNOUKAS, G. HADJIGEORGIOU, S. KOUTSIAS, S. RALLI, N. ROUSAS, B. NEMES, Z. JARANYI, A. SZABO, D. VARGA, P. BARZO, M. BODOSI, E. FAKO, B. FULOP, A. KUNCZ, E. NAGY, T. NEMETH, S. PAZDERNYIK, K. SKOBA, E. VOROS, S. N. HAIDER, J. HARBISON, P. MADHAVAN, D. MOORE, R. BEYAR, A. HOFFMAN, T. KARRAM, A. KERNER, E. NIKOLSKY, S. NITECKI, G. AMATUCCI, P. VITTORIO, Prof. FREDERICO, D. MARINAZZO, G. REGINA, A. GIAQUINTA, F. PATTI, M. VEROUX, P. VEROUX, L. ADOBBATI, G. BERTONI, P. BIANCHI, R. CASANA, L. CIRENI, L. MARTELL, V. TOLVA, L. ARCURI, F. CASONI, G. COPPI, R. MORATTO, J. VERONESI, G. BAJARDI, G. SAVETTIERI, R. CORBETTA, A. ODERO, P. QUARETTI, Z. THYRION, P. CAO, V. CASO, P. DERANGO, L. FARCHIONI, G. PARLANI, G. MALFERRARI, F. STROZZI, N. TUSINI, E. VECCHIATI, A. BIELLO, L. CAPOCCIA, D. MENNA, A Ritta RIZZO, E. SBARIGIA, F. SPEZIALE, D. TONI, M. GIOVANNI, G. MEOLA, G. NANO, M. T. OCCIUTO, S. STEGHER, D. TEALDI, F. ACCROCCA, C. AMBROGI, R. BARBAZZA, G. MARCUCCI, A. CAPPELLI, G De DONATO, G. PALASCIANO, D. PIERAGALLI, C. SETACCI, F. SETTACI, C. LABATE, E. FERRERO, M. FERRI, F. NESSI, A. VIAZZO, P. CASTELLI, M. L. DELODOVICI, M. FERRARIO, G. PIFFARETTI, G. TOMEI, E. FURUI, T. INOUE, R. KONDO, Y. MATSUMOTO, H. SHIMIZU, B. AIDASHOVA, N. KOSPANOV, R. LYSSENKO, D. MUSSAGALIEV, G J De BORST, A G Den HARTOG, R. LO, F. MOLL, R. TOOROP, H B Van Der WORP, E. J. VONKEN, S. BAKKE, K. KROHG-SORENSEN, M. SKJELLAND, P. ANDZIAK, S. DRELICHOWSKI, M. DRATWICKI, R. GIL, W. IWANOWSKI, K. KONCEWICZ, M. NOWICKI, J. PNIEWSKI, J. RZEZAK, P. SEWERYNIAK, P. BIALEK, Z. BIEJAT, W. CZEPEL, A. CZLONKOWSKA, A. DOWZENKO, J. JEDZREJEWSKA, A. KOBAYASHI, J. LESZEZYUSKI, A. MALEK, J. POLANSKI, R. PROCZKA, M. SKORSKI, M. SZOSTEK, N. ALEKSIC, S. BABIC, J. KOLAR, D. RADAK, D. SAGIC, S. TANASKOVIC, M. COLIC, L. DAVIDOVIC, D. JOVANOVIC, I. KONCAR, D. BARTKO, P. BENO, F. RUSNAK, K. ZELENAK, M. GASPARINI, A. GRAD, I. KOMPARA, Z. MILOSEVIC, V. FLIS, J. MATELA, K. MIKSIC, F. MILOTIC, B. MRDJA, B. STIRN, E. TETICKOVIC, A. CHAMORRO, V. OBACH, V. RIAMBAU, S. ROMAN, E. BLANCO, A. Y. IZQUIERDO, M. GUERRA, E. CAMPBELL, H. LINDGREN, J. NYBERG, G. PLATE, H. PARSSON, P. QVARFORDT, S. ACOSTA, K. BJORSES, K. BRANDT, N. DIAS, A. GOTTSATER, J. HOLST, T. KRISTMUNDSSON, T. KUHME, T. KOLBEL, B. LINDBLAD, M. LINDH, M. MALINA, T. OHRLANDER, T. RESCH, V. RONNLE, B. SONESSON, M. WARVSTEN, Z. ZDANOWSKI, B. BENGT, M. DELLE, J. FORMGREN, P. GILLGREN, L. JARL, T. B. KALL, P. KONRAD, N. NYMAN, C. SKIOLDEBRAND, J. STEUER, R. TAKOLANDER, F. J. AHLHELM, L. BONATI, S. S. ENGELTER, T. EUGSTER, H. GENSICKE, P. LYRER, L. MARIANI, P. STIERLI, C. STIPPICH, T. WOLFF, A. MEHRZAD, E. BROWN, B. ESISI, N. BUTLER, D. J. DAY, P. HAYES, N. HIGGINS, E. JUMILLA, P. MARTIN, J. MITCHELL, K. VARTY, A. BIRT, P. DAVIES, J. GEORGE, A. GRAHAM, L. JONKER, T. JOSEPH, N. KELSALL, C. POTTS, T. WILSON, P. DAVEY, R. HAYMAN, G. TERVITT, A. ABDUL-HAMIQ, J. BRYCE, I. CHETTER, D. ETTLES, R. LAKSHMINARAYAN, K. MITCHELSONM, C. RHYMES, G. ROBINSON, P. SCOTT, A. VICKERS, H. BAHT, I. BALOGUN, I. BURGER, L. COWIE, G. GUNATHILAGAN, D. HARGROVES, R. INSALL, S. JONES, H. RUDENKO, J. SENARATNE, G. THOMAS, A. THOMSON, P. ENEVOLDSON, H. NAHSER, I. O'BRIAN, F Torella D WATLING, R. WHITE, A. CLIFTON, C. ELEY, N. KHANOM, J. O'REILLY, A. PEREIRA, C. BICKNELL, N. CHESHIRE, R. GIBBS, M. HAMADY, A. JAMES, M. JENKINS, A. LACEY, M. MIRESKANDARI, T. SACHS, J. WOLFE, D. HARDY, F. JUSTIN, L. PHIRI, L. SEKARAN, S. SETHURAMAN, L. TATE, J. AKYEA-MENSAH, A. CHRISOPOULOU, J. V. SMYTH, I. NICHOL, A. PARRY, G. YOUNG, M. CLARKE, M. DAVIS, A. DIXIT, A. DYKER, G. FORD, R. JACKSON, S. KAPPADATH, D. LAMBERT, T. LEES, S. LOUW, S. MACDONALD, N. PARR, G. STANSBY, L. WALES, V. WEALLEANS, L. WILSON, M. WYATT, P. DORMAN, A. HUGHES, D. JONES, A. D. MENDELOW, H. RODGERS, S. MACSWEENEY, N. MCCONACHIE, A. SOUTHAM, W. SUNMAN, D. BRILEY, C. DARBY, A. HANDA, L. HANDS, W. KUKER, K. MICHAEL, J. PERKINS, U. SCHULZ, D. SMITH, R. TEAL, M. DONNELLY, S. D'SOUZA, A Asehosem EGUN, B. GREGORY, C. KELLY, S. PUNEKAR, S. RAJ, D. SERIKI, G. THOMSON, J. BEARD, T. CLEVELAND, J. HUMPHREYS, A. JENKINS, C. KING, R. LONSDALE, R. NAIR, S. NAWAZ, F. OKHUOYA, D. TURNER, G. VENABLES, J. BROWN, R. DURAIRAJAN, P. GUYLER, P. HARMAN, M. JAKEWAYS, C. KHUOGE, A. KUNDU, T. LOGANATHAN, D. SINHA, V. THOMPSON, S. TYSOE, Dr. BARER, A. BROWN, S. CRAWFORD, P. DUNLOP, Dr. MAJMUDAR, D. MITCHELL, Dr. O'BRIEN, Dr. O'CONNELL, Dr. SCOTT, S. VETRIVEL, R. ASHLEIGH, S. BUTTERFIELD, G. GAMBLE, J. GHOSH, C. MCCOLLUM, M. WELCH, S. WELSH, V. KAZAN, M. NAZZAL and V. RAMSEY-WILLIAMS. Status Update and Interim Results from the Asymptomatic Carotid Surgery Trial-2 (ACST-2). EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. Londýn: W B SAUNDERS CO LTD, 2013, vol. 46, No 5, p. 510-518. ISSN 1078-5884. Available from: https://dx.doi.org/10.1016/j.ejvs.2013.07.020.

Basic information

Original name

Status Update and Interim Results from the Asymptomatic Carotid Surgery Trial-2 (ACST-2)

Authors

HALLIDAY, Alison (826 United Kingdom of Great Britain and Northern Ireland), Richard BULBULIA (826 United Kingdom of Great Britain and Northern Ireland), William GRAY (840 United States of America), Ally NAUGHTEN (826 United Kingdom of Great Britain and Northern Ireland), Anne den HARTOG (826 United Kingdom of Great Britain and Northern Ireland), Antonella DELMESTRI (826 United Kingdom of Great Britain and Northern Ireland), Carol WALLIS (826 United Kingdom of Great Britain and Northern Ireland), Stephanie le CONTE (826 United Kingdom of Great Britain and Northern Ireland), Sumaira MACDONALD (826 United Kingdom of Great Britain and Northern Ireland), P. CRAS (56 Belgium), J. M. H. HENDRIKS (56 Belgium), P. LAUWERS (56 Belgium), M. HERTOGHS (56 Belgium), P Van SCHIL (56 Belgium), L De JAEGHER (56 Belgium), P. PEETERS (56 Belgium), J. VERBIST (56 Belgium), D. DENDOOVEN (56 Belgium), J De LETTER (56 Belgium), G. VANHOOREN (56 Belgium), P. ASTARCI (56 Belgium), I. CAPRON (56 Belgium), C. CHOGHARI (56 Belgium), F. HAMMER (56 Belgium), V. LACROIX (56 Belgium), A. PEETERS (56 Belgium), R. VERHELST (56 Belgium), M. BOSIERS (56 Belgium), K De MEESTER (56 Belgium), K. DELOOSE (56 Belgium), E Van BUGGENHOUT (56 Belgium), E. VINCK (56 Belgium), M. GEENENS (56 Belgium), D. HEMELSOET (56 Belgium), I Van HERZEELE (56 Belgium), F. VERMASSEN (56 Belgium), G De KOSTER (56 Belgium), Q. DESIRON (56 Belgium), A de Noordhout MAERTENS (56 Belgium), D. MALMENDIER (56 Belgium), M. MASSOZ (56 Belgium), G. SAAD (56 Belgium), S. CIRELLI (56 Belgium), P. DORMAL (56 Belgium), P. LERUT (56 Belgium), E. THUES (56 Belgium), S. COUTTS (124 Canada), A. DEMCHUK (124 Canada), M. HILL (124 Canada), M. HUDON (124 Canada), G. KLEIN (124 Canada), M. MCCLELLAND (124 Canada), W. MORRISH (124 Canada), G. SAMIS (124 Canada), G. SUTHERLAND (124 Canada), T. WATSON (124 Canada), J. WONG (124 Canada), Bao LIU (156 China), Chang-Wei LIU (156 China), L. BARANKOVA (203 Czech Republic), V. CHLOUBA (203 Czech Republic), J. FIEDLER (203 Czech Republic), V. PRIBAN (203 Czech Republic), L. STERBA (203 Czech Republic), L. KALABOVA (203 Czech Republic), Z. KRIZ (203 Czech Republic), P. KRUPA (203 Czech Republic), M. PRIVARA (203 Czech Republic), M. REIF (203 Czech Republic), L. SOUCKOVA (203 Czech Republic), Robert STAFFA (203 Czech Republic, belonging to the institution), Robert VLACHOVSKÝ (203 Czech Republic, guarantor, belonging to the institution), B. VOJTISEK (203 Czech Republic), T. HRBAC (203 Czech Republic), M. KULIHA (203 Czech Republic), V. PROCHAZKA (203 Czech Republic), M. ROUBEC (203 Czech Republic), D. SKOLOUDIK (203 Czech Republic), F Abd ALLAH (818 Egypt), M. H. ELDESSOKI (818 Egypt), H Heshmat KASSEM (818 Egypt), H Soliman GHARIEB (818 Egypt), J. M. CARDON (250 France), A Le Gallou WITTENBERG (250 France), E. ALLAIRE (250 France), J. P. BECQUEMIN (250 France), F. COCHENNEC (250 France), P. DESGRANGES (250 France), H. HOSSEINI (250 France), H. KOBEITER (250 France), J. MARZELLE (250 France), P. BERGERON (250 France), R. PADOVANI (250 France), J. C. TRASTOUR (250 France), B. BIERMAIER (276 Germany), H. M. GISSLER (276 Germany), C. KLOTZSCH (276 Germany), T. PFEIFFER (276 Germany), R. SCHNEIDER (276 Germany), L. SOEHL (276 Germany), M. WENNRIH (276 Germany), Y. BAUSBACK (276 Germany), S. BOTSIOS (276 Germany), D. BRANZAN (276 Germany), S. BRAUNLICH (276 Germany), H. HOLZER (276 Germany), J. LENZER (276 Germany), C. REICHENBECHER (276 Germany), C. PIORKOWSKI (276 Germany), J. SCHUSTER (276 Germany), D. SCHEINERT (276 Germany), A. SCHMIDT (276 Germany), M. ULRICH (276 Germany), M. WERNER (276 Germany), A. COSTER (276 Germany), A. ENGELHARDT (276 Germany), C. M. RATUSINSKI (276 Germany), B. BEREKOVEN (276 Germany), K. FRERKER (276 Germany), V. GORDON (276 Germany), G. TORSELLO (276 Germany), I. BELLENIS (300 Greece), A. POLYDOROU (300 Greece), V. POLYDOROU (300 Greece), A. TAVERNARAKIS (300 Greece), N. IOANNOU (300 Greece), M. TERZOUDI (300 Greece), E. CHATZINIKOU (300 Greece), A. GIANNOUKAS (300 Greece), G. HADJIGEORGIOU (300 Greece), S. KOUTSIAS (300 Greece), S. RALLI (300 Greece), N. ROUSAS (300 Greece), B. NEMES (348 Hungary), Z. JARANYI (348 Hungary), A. SZABO (348 Hungary), D. VARGA (348 Hungary), P. BARZO (348 Hungary), M. BODOSI (348 Hungary), E. FAKO (348 Hungary), B. FULOP (348 Hungary), A. KUNCZ (348 Hungary), E. NAGY (348 Hungary), T. NEMETH (348 Hungary), S. PAZDERNYIK (348 Hungary), K. SKOBA (348 Hungary), E. VOROS (348 Hungary), S. N. HAIDER (372 Ireland), J. HARBISON (372 Ireland), P. MADHAVAN (372 Ireland), D. MOORE (372 Ireland), R. BEYAR (376 Israel), A. HOFFMAN (376 Israel), T. KARRAM (376 Israel), A. KERNER (376 Israel), E. NIKOLSKY (376 Israel), S. NITECKI (376 Israel), G. AMATUCCI (380 Italy), P. VITTORIO (380 Italy), Prof. FREDERICO (380 Italy), D. MARINAZZO (380 Italy), G. REGINA (380 Italy), A. GIAQUINTA (380 Italy), F. PATTI (380 Italy), M. VEROUX (380 Italy), P. VEROUX (380 Italy), L. ADOBBATI (380 Italy), G. BERTONI (380 Italy), P. BIANCHI (380 Italy), R. CASANA (380 Italy), L. CIRENI (380 Italy), L. MARTELL (380 Italy), V. TOLVA (380 Italy), L. ARCURI (380 Italy), F. CASONI (380 Italy), G. COPPI (380 Italy), R. MORATTO (380 Italy), J. VERONESI (380 Italy), G. BAJARDI (380 Italy), G. SAVETTIERI (380 Italy), R. CORBETTA (380 Italy), A. ODERO (380 Italy), P. QUARETTI (380 Italy), Z. THYRION (380 Italy), P. CAO (380 Italy), V. CASO (380 Italy), P. DERANGO (380 Italy), L. FARCHIONI (380 Italy), G. PARLANI (380 Italy), G. MALFERRARI (380 Italy), F. STROZZI (380 Italy), N. TUSINI (380 Italy), E. VECCHIATI (380 Italy), A. BIELLO (380 Italy), L. CAPOCCIA (380 Italy), D. MENNA (380 Italy), A Ritta RIZZO (380 Italy), E. SBARIGIA (380 Italy), F. SPEZIALE (380 Italy), D. TONI (380 Italy), M. GIOVANNI (380 Italy), G. MEOLA (380 Italy), G. NANO (380 Italy), M. T. OCCIUTO (380 Italy), S. STEGHER (380 Italy), D. TEALDI (380 Italy), F. ACCROCCA (380 Italy), C. AMBROGI (380 Italy), R. BARBAZZA (380 Italy), G. MARCUCCI (380 Italy), A. CAPPELLI (380 Italy), G De DONATO (380 Italy), G. PALASCIANO (380 Italy), D. PIERAGALLI (380 Italy), C. SETACCI (380 Italy), F. SETTACI (380 Italy), C. LABATE (380 Italy), E. FERRERO (380 Italy), M. FERRI (380 Italy), F. NESSI (380 Italy), A. VIAZZO (380 Italy), P. CASTELLI (380 Italy), M. L. DELODOVICI (380 Italy), M. FERRARIO (380 Italy), G. PIFFARETTI (380 Italy), G. TOMEI (380 Italy), E. FURUI (392 Japan), T. INOUE (392 Japan), R. KONDO (392 Japan), Y. MATSUMOTO (392 Japan), H. SHIMIZU (392 Japan), B. AIDASHOVA (398 Kazakhstan), N. KOSPANOV (398 Kazakhstan), R. LYSSENKO (398 Kazakhstan), D. MUSSAGALIEV (398 Kazakhstan), G J De BORST (528 Netherlands), A G Den HARTOG (528 Netherlands), R. LO (528 Netherlands), F. MOLL (528 Netherlands), R. TOOROP (528 Netherlands), H B Van Der WORP (528 Netherlands), E. J. VONKEN (528 Netherlands), S. BAKKE (578 Norway), K. KROHG-SORENSEN (578 Norway), M. SKJELLAND (578 Norway), P. ANDZIAK (616 Poland), S. DRELICHOWSKI (616 Poland), M. DRATWICKI (616 Poland), R. GIL (616 Poland), W. IWANOWSKI (616 Poland), K. KONCEWICZ (616 Poland), M. NOWICKI (616 Poland), J. PNIEWSKI (616 Poland), J. RZEZAK (616 Poland), P. SEWERYNIAK (616 Poland), P. BIALEK (616 Poland), Z. BIEJAT (616 Poland), W. CZEPEL (616 Poland), A. CZLONKOWSKA (616 Poland), A. DOWZENKO (616 Poland), J. JEDZREJEWSKA (616 Poland), A. KOBAYASHI (616 Poland), J. LESZEZYUSKI (616 Poland), A. MALEK (616 Poland), J. POLANSKI (616 Poland), R. PROCZKA (616 Poland), M. SKORSKI (616 Poland), M. SZOSTEK (616 Poland), N. ALEKSIC (688 Serbia), S. BABIC (688 Serbia), J. KOLAR (688 Serbia), D. RADAK (688 Serbia), D. SAGIC (688 Serbia), S. TANASKOVIC (688 Serbia), M. COLIC (688 Serbia), L. DAVIDOVIC (688 Serbia), D. JOVANOVIC (688 Serbia), I. KONCAR (688 Serbia), D. BARTKO (703 Slovakia), P. BENO (703 Slovakia), F. RUSNAK (703 Slovakia), K. ZELENAK (703 Slovakia), M. GASPARINI (705 Slovenia), A. GRAD (705 Slovenia), I. KOMPARA (705 Slovenia), Z. MILOSEVIC (705 Slovenia), V. FLIS (705 Slovenia), J. MATELA (705 Slovenia), K. MIKSIC (705 Slovenia), F. MILOTIC (705 Slovenia), B. MRDJA (705 Slovenia), B. STIRN (705 Slovenia), E. TETICKOVIC (705 Slovenia), A. CHAMORRO (724 Spain), V. OBACH (724 Spain), V. RIAMBAU (724 Spain), S. ROMAN (724 Spain), E. BLANCO (724 Spain), A. Y. IZQUIERDO (724 Spain), M. GUERRA (724 Spain), E. CAMPBELL (752 Sweden), H. LINDGREN (752 Sweden), J. NYBERG (752 Sweden), G. PLATE (752 Sweden), H. PARSSON (752 Sweden), P. QVARFORDT (752 Sweden), S. ACOSTA (752 Sweden), K. BJORSES (752 Sweden), K. BRANDT (752 Sweden), N. DIAS (752 Sweden), A. GOTTSATER (752 Sweden), J. HOLST (752 Sweden), T. KRISTMUNDSSON (752 Sweden), T. KUHME (752 Sweden), T. KOLBEL (752 Sweden), B. LINDBLAD (752 Sweden), M. LINDH (752 Sweden), M. MALINA (752 Sweden), T. OHRLANDER (752 Sweden), T. RESCH (752 Sweden), V. RONNLE (752 Sweden), B. SONESSON (752 Sweden), M. WARVSTEN (752 Sweden), Z. ZDANOWSKI (752 Sweden), B. BENGT (752 Sweden), M. DELLE (752 Sweden), J. FORMGREN (752 Sweden), P. GILLGREN (752 Sweden), L. JARL (752 Sweden), T. B. KALL (752 Sweden), P. KONRAD (752 Sweden), N. NYMAN (752 Sweden), C. SKIOLDEBRAND (752 Sweden), J. STEUER (752 Sweden), R. TAKOLANDER (752 Sweden), F. J. AHLHELM (756 Switzerland), L. BONATI (756 Switzerland), S. S. ENGELTER (756 Switzerland), T. EUGSTER (756 Switzerland), H. GENSICKE (756 Switzerland), P. LYRER (756 Switzerland), L. MARIANI (756 Switzerland), P. STIERLI (756 Switzerland), C. STIPPICH (756 Switzerland), T. WOLFF (756 Switzerland), A. MEHRZAD (826 United Kingdom of Great Britain and Northern Ireland), E. BROWN (826 United Kingdom of Great Britain and Northern Ireland), B. ESISI (826 United Kingdom of Great Britain and Northern Ireland), N. BUTLER (826 United Kingdom of Great Britain and Northern Ireland), D. J. DAY (826 United Kingdom of Great Britain and Northern Ireland), P. HAYES (826 United Kingdom of Great Britain and Northern Ireland), N. HIGGINS (826 United Kingdom of Great Britain and Northern Ireland), E. JUMILLA (826 United Kingdom of Great Britain and Northern Ireland), P. MARTIN (826 United Kingdom of Great Britain and Northern Ireland), J. MITCHELL (826 United Kingdom of Great Britain and Northern Ireland), K. VARTY (826 United Kingdom of Great Britain and Northern Ireland), A. BIRT (826 United Kingdom of Great Britain and Northern Ireland), P. DAVIES (826 United Kingdom of Great Britain and Northern Ireland), J. GEORGE (826 United Kingdom of Great Britain and Northern Ireland), A. GRAHAM (826 United Kingdom of Great Britain and Northern Ireland), L. JONKER (826 United Kingdom of Great Britain and Northern Ireland), T. JOSEPH (826 United Kingdom of Great Britain and Northern Ireland), N. KELSALL (826 United Kingdom of Great Britain and Northern Ireland), C. POTTS (826 United Kingdom of Great Britain and Northern Ireland), T. WILSON (826 United Kingdom of Great Britain and Northern Ireland), P. DAVEY (826 United Kingdom of Great Britain and Northern Ireland), R. HAYMAN (826 United Kingdom of Great Britain and Northern Ireland), G. TERVITT (826 United Kingdom of Great Britain and Northern Ireland), A. ABDUL-HAMIQ (826 United Kingdom of Great Britain and Northern Ireland), J. BRYCE (826 United Kingdom of Great Britain and Northern Ireland), I. CHETTER (826 United Kingdom of Great Britain and Northern Ireland), D. ETTLES (826 United Kingdom of Great Britain and Northern Ireland), R. LAKSHMINARAYAN (826 United Kingdom of Great Britain and Northern Ireland), K. MITCHELSONM (826 United Kingdom of Great Britain and Northern Ireland), C. RHYMES (826 United Kingdom of Great Britain and Northern Ireland), G. ROBINSON (826 United Kingdom of Great Britain and Northern Ireland), P. SCOTT (826 United Kingdom of Great Britain and Northern Ireland), A. VICKERS (826 United Kingdom of Great Britain and Northern Ireland), H. BAHT (826 United Kingdom of Great Britain and Northern Ireland), I. BALOGUN (826 United Kingdom of Great Britain and Northern Ireland), I. BURGER (826 United Kingdom of Great Britain and Northern Ireland), L. COWIE (826 United Kingdom of Great Britain and Northern Ireland), G. GUNATHILAGAN (826 United Kingdom of Great Britain and Northern Ireland), D. HARGROVES (826 United Kingdom of Great Britain and Northern Ireland), R. INSALL (826 United Kingdom of Great Britain and Northern Ireland), S. JONES (826 United Kingdom of Great Britain and Northern Ireland), H. RUDENKO (826 United Kingdom of Great Britain and Northern Ireland), J. SENARATNE (826 United Kingdom of Great Britain and Northern Ireland), G. THOMAS (826 United Kingdom of Great Britain and Northern Ireland), A. THOMSON (826 United Kingdom of Great Britain and Northern Ireland), P. ENEVOLDSON (826 United Kingdom of Great Britain and Northern Ireland), H. NAHSER (826 United Kingdom of Great Britain and Northern Ireland), I. O'BRIAN (826 United Kingdom of Great Britain and Northern Ireland), F Torella D WATLING (826 United Kingdom of Great Britain and Northern Ireland), R. WHITE (826 United Kingdom of Great Britain and Northern Ireland), A. CLIFTON (826 United Kingdom of Great Britain and Northern Ireland), C. ELEY (826 United Kingdom of Great Britain and Northern Ireland), N. KHANOM (826 United Kingdom of Great Britain and Northern Ireland), J. O'REILLY (826 United Kingdom of Great Britain and Northern Ireland), A. PEREIRA (826 United Kingdom of Great Britain and Northern Ireland), C. BICKNELL (826 United Kingdom of Great Britain and Northern Ireland), N. CHESHIRE (826 United Kingdom of Great Britain and Northern Ireland), R. GIBBS (826 United Kingdom of Great Britain and Northern Ireland), M. HAMADY (826 United Kingdom of Great Britain and Northern Ireland), A. JAMES (826 United Kingdom of Great Britain and Northern Ireland), M. JENKINS (826 United Kingdom of Great Britain and Northern Ireland), A. LACEY (826 United Kingdom of Great Britain and Northern Ireland), M. MIRESKANDARI (826 United Kingdom of Great Britain and Northern Ireland), T. SACHS (826 United Kingdom of Great Britain and Northern Ireland), J. WOLFE (826 United Kingdom of Great Britain and Northern Ireland), D. HARDY (826 United Kingdom of Great Britain and Northern Ireland), F. JUSTIN (826 United Kingdom of Great Britain and Northern Ireland), L. PHIRI (826 United Kingdom of Great Britain and Northern Ireland), L. SEKARAN (826 United Kingdom of Great Britain and Northern Ireland), S. SETHURAMAN (826 United Kingdom of Great Britain and Northern Ireland), L. TATE (826 United Kingdom of Great Britain and Northern Ireland), J. AKYEA-MENSAH (826 United Kingdom of Great Britain and Northern Ireland), A. CHRISOPOULOU (826 United Kingdom of Great Britain and Northern Ireland), J. V. SMYTH (826 United Kingdom of Great Britain and Northern Ireland), I. NICHOL (826 United Kingdom of Great Britain and Northern Ireland), A. PARRY (826 United Kingdom of Great Britain and Northern Ireland), G. YOUNG (826 United Kingdom of Great Britain and Northern Ireland), M. CLARKE (826 United Kingdom of Great Britain and Northern Ireland), M. DAVIS (826 United Kingdom of Great Britain and Northern Ireland), A. DIXIT (826 United Kingdom of Great Britain and Northern Ireland), A. DYKER (826 United Kingdom of Great Britain and Northern Ireland), G. FORD (826 United Kingdom of Great Britain and Northern Ireland), R. JACKSON (826 United Kingdom of Great Britain and Northern Ireland), S. KAPPADATH (826 United Kingdom of Great Britain and Northern Ireland), D. LAMBERT (826 United Kingdom of Great Britain and Northern Ireland), T. LEES (826 United Kingdom of Great Britain and Northern Ireland), S. LOUW (826 United Kingdom of Great Britain and Northern Ireland), S. MACDONALD (826 United Kingdom of Great Britain and Northern Ireland), N. PARR (826 United Kingdom of Great Britain and Northern Ireland), G. STANSBY (826 United Kingdom of Great Britain and Northern Ireland), L. WALES (826 United Kingdom of Great Britain and Northern Ireland), V. WEALLEANS (826 United Kingdom of Great Britain and Northern Ireland), L. WILSON (826 United Kingdom of Great Britain and Northern Ireland), M. WYATT (826 United Kingdom of Great Britain and Northern Ireland), P. DORMAN (826 United Kingdom of Great Britain and Northern Ireland), A. HUGHES (826 United Kingdom of Great Britain and Northern Ireland), D. JONES (826 United Kingdom of Great Britain and Northern Ireland), A. D. MENDELOW (826 United Kingdom of Great Britain and Northern Ireland), H. RODGERS (826 United Kingdom of Great Britain and Northern Ireland), S. MACSWEENEY (826 United Kingdom of Great Britain and Northern Ireland), N. MCCONACHIE (826 United Kingdom of Great Britain and Northern Ireland), A. SOUTHAM (826 United Kingdom of Great Britain and Northern Ireland), W. SUNMAN (826 United Kingdom of Great Britain and Northern Ireland), D. BRILEY (826 United Kingdom of Great Britain and Northern Ireland), C. DARBY (826 United Kingdom of Great Britain and Northern Ireland), A. HANDA (826 United Kingdom of Great Britain and Northern Ireland), L. HANDS (826 United Kingdom of Great Britain and Northern Ireland), W. KUKER (826 United Kingdom of Great Britain and Northern Ireland), K. MICHAEL (826 United Kingdom of Great Britain and Northern Ireland), J. PERKINS (826 United Kingdom of Great Britain and Northern Ireland), U. SCHULZ (826 United Kingdom of Great Britain and Northern Ireland), D. SMITH (826 United Kingdom of Great Britain and Northern Ireland), R. TEAL (826 United Kingdom of Great Britain and Northern Ireland), M. DONNELLY (826 United Kingdom of Great Britain and Northern Ireland), S. D'SOUZA (826 United Kingdom of Great Britain and Northern Ireland), A Asehosem EGUN (826 United Kingdom of Great Britain and Northern Ireland), B. GREGORY (826 United Kingdom of Great Britain and Northern Ireland), C. KELLY (826 United Kingdom of Great Britain and Northern Ireland), S. PUNEKAR (826 United Kingdom of Great Britain and Northern Ireland), S. RAJ (826 United Kingdom of Great Britain and Northern Ireland), D. SERIKI (826 United Kingdom of Great Britain and Northern Ireland), G. THOMSON (826 United Kingdom of Great Britain and Northern Ireland), J. BEARD (826 United Kingdom of Great Britain and Northern Ireland), T. CLEVELAND (826 United Kingdom of Great Britain and Northern Ireland), J. HUMPHREYS (826 United Kingdom of Great Britain and Northern Ireland), A. JENKINS (826 United Kingdom of Great Britain and Northern Ireland), C. KING (826 United Kingdom of Great Britain and Northern Ireland), R. LONSDALE (826 United Kingdom of Great Britain and Northern Ireland), R. NAIR (826 United Kingdom of Great Britain and Northern Ireland), S. NAWAZ (826 United Kingdom of Great Britain and Northern Ireland), F. OKHUOYA (826 United Kingdom of Great Britain and Northern Ireland), D. TURNER (826 United Kingdom of Great Britain and Northern Ireland), G. VENABLES (826 United Kingdom of Great Britain and Northern Ireland), J. BROWN (826 United Kingdom of Great Britain and Northern Ireland), R. DURAIRAJAN (826 United Kingdom of Great Britain and Northern Ireland), P. GUYLER (826 United Kingdom of Great Britain and Northern Ireland), P. HARMAN (826 United Kingdom of Great Britain and Northern Ireland), M. JAKEWAYS (826 United Kingdom of Great Britain and Northern Ireland), C. KHUOGE (826 United Kingdom of Great Britain and Northern Ireland), A. KUNDU (826 United Kingdom of Great Britain and Northern Ireland), T. LOGANATHAN (826 United Kingdom of Great Britain and Northern Ireland), D. SINHA (826 United Kingdom of Great Britain and Northern Ireland), V. THOMPSON (826 United Kingdom of Great Britain and Northern Ireland), S. TYSOE (826 United Kingdom of Great Britain and Northern Ireland), Dr. BARER (826 United Kingdom of Great Britain and Northern Ireland), A. BROWN (826 United Kingdom of Great Britain and Northern Ireland), S. CRAWFORD (826 United Kingdom of Great Britain and Northern Ireland), P. DUNLOP (826 United Kingdom of Great Britain and Northern Ireland), Dr. MAJMUDAR (826 United Kingdom of Great Britain and Northern Ireland), D. MITCHELL (826 United Kingdom of Great Britain and Northern Ireland), Dr. O'BRIEN (826 United Kingdom of Great Britain and Northern Ireland), Dr. O'CONNELL (826 United Kingdom of Great Britain and Northern Ireland), Dr. SCOTT (826 United Kingdom of Great Britain and Northern Ireland), S. VETRIVEL (826 United Kingdom of Great Britain and Northern Ireland), R. ASHLEIGH (826 United Kingdom of Great Britain and Northern Ireland), S. BUTTERFIELD (826 United Kingdom of Great Britain and Northern Ireland), G. GAMBLE (826 United Kingdom of Great Britain and Northern Ireland), J. GHOSH (826 United Kingdom of Great Britain and Northern Ireland), C. MCCOLLUM (826 United Kingdom of Great Britain and Northern Ireland), M. WELCH (826 United Kingdom of Great Britain and Northern Ireland), S. WELSH (826 United Kingdom of Great Britain and Northern Ireland), V. KAZAN (840 United States of America), M. NAZZAL (840 United States of America) and V. RAMSEY-WILLIAMS (840 United States of America)

Edition

EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Londýn, W B SAUNDERS CO LTD, 2013, 1078-5884

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.070

RIV identification code

RIV/00216224:14110/13:00071242

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.ejvs.2013.07.020

UT WoS

000327232500004

Keywords in English

Carotid artery stenosis; Stroke; Carotid artery stenting; Carotid endarterectomy; Randomized controlled trial

Tags

International impact, Reviewed

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Abstract

V originále

Objectives: ACST-2 is currently the largest trial ever conducted to compare carotid artery stenting (CAS) with carotid endarterectomy (CEA) in patients with severe asymptomatic carotid stenosis requiring revascularization. Methods: Patients are entered into ACST-2 when revascularization is felt to be clearly indicated, when CEA and CAS are both possible, but where there is substantial uncertainty as to which is most appropriate. Trial surgeons and interventionalists are expected to use their usual techniques and CE-approved devices. We report baseline characteristics and blinded combined interim results for 30-day mortality and major morbidity for 986 patients in the ongoing trial up to September 2012. Results: A total of 986 patients (687 men, 299 women), mean age 68.7 years (SD +/- 8.1) were randomized equally to CEA or CAS. Most (96%) had ipsilateral stenosis of 70-99% (median 80%) with contralateral stenoses of 50-99% in 30% and contralateral occlusion in 8%. Patients were on appropriate medical treatment. For 691 patients undergoing intervention with at least 1-month follow-up and Rankin scoring at 6 months for any stroke, the overall serious cardiovascular event rate of periprocedural (within 30 days) disabling stroke, fatal myocardial infarction, and death at 30 days was 1.0%. Conclusions: Early ACST-2 results suggest contemporary carotid intervention for asymptomatic stenosis has a low risk of serious morbidity and mortality, on par with other recent trials. The trial continues to recruit, to monitor periprocedural events and all types of stroke, aiming to randomize up to 5,000 patients to determine any differential outcomes between interventions.